Untangling The Double Helix
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| Author | : James C. Wang |
| Publisher | : |
| Total Pages | : 252 |
| Release | : 2009 |
| Genre | : DNA topoisomerases |
| ISBN | : |
The problem of unraveling two intertwined strands during the duplication of DNA was recognized shortly after the proposal of the DNA double helix structure in 1953. A group of enzymes called DNA topoisomerases solve this problem by breaking and rejoining DNA molecules in a controlled manner, thereby allowing strands to be passed through each other and thus untangled—not just during DNA replication, but also during many other basic cellular processes. Because of their intimate involvement in the workings of the cell, topoisomerases are also the logical targets of many antibiotics (including Cipro) and anticancer agents. This book, written by James Wang, the discoverer of the first topoisomerase and a leader in the field since, presents ten chapters covering the historical backdrop of the DNA entanglement problem and the discovery of the DNA topoisomerases, how DNA topoisomerases perform their magic in DNA replication, transcription, genetic recombination and chromosome condensation, and how they are targets of therapeutic agents. The book should appeal to readers from undergraduates upwards with interests in the biological and clinical aspects of topoisomerase function, or in the mathematics and physics of topology.
| Author | : Maureen L. Condic |
| Publisher | : University of Notre Dame Pess |
| Total Pages | : 212 |
| Release | : 2020-02-28 |
| Genre | : Medical |
| ISBN | : 0268107076 |
Scientists and philosophers have long struggled to answer the questions of when human life begins and when human life has inherent value. The phenomenon of identical (monozygotic) twinning presents a significant challenge to the view that human life and human personhood begin at conception. The fact that a single embryo can split to generate two (or more) genetically identical embryos seems to defy the notion that prior to splitting an embryo can be a single human individual. In Untangling Twinning, Maureen Condic looks at the questions raised by human twinning based on a unique synthesis of molecular developmental biology and Aristotelian philosophy. She begins with a brief historical analysis of the current scientific perspective on the embryo and proceeds to address the major philosophic and scientific concerns regarding human twinning and embryo fusion: Is the embryo one human or two (or even more)? Does the original embryo die, and if not, which of the twins is the original? Who are the parents of the twins? What do twins, chimeras, cloning, and asexual reproduction in humans mean? And what does the science of human embryology say about human ensoulment, human individuality, and human value? Condic's original approach makes a unique contribution to the discussion of human value and human individuality, and offers a clear, evidence-based resolution to questions raised by human twinning. The book is written for students and scholars of bioethics, scientists, theologians, and attorneys who are involved in questions surrounding the human embryo.
| Author | : Pier Luigi Gentili |
| Publisher | : CRC Press |
| Total Pages | : 568 |
| Release | : 2018-09-03 |
| Genre | : Mathematics |
| ISBN | : 0429847556 |
Complex Systems are natural systems that science is unable to describe exhaustively. Examples of Complex Systems are both unicellular and multicellular living beings; human brains; human immune systems; ecosystems; human societies; the global economy; the climate and geology of our planet. This book is an account of a marvelous interdisciplinary journey the author made to understand properties of the Complex Systems. He has undertaken his trip, equipped with the fundamental principles of physical chemistry, in particular, the Second Law of Thermodynamics that describes the spontaneous evolution of our universe, and the tools of Non-linear dynamics. By dealing with many disciplines, in particular, chemistry, biology, physics, economy, and philosophy, the author demonstrates that Complex Systems are intertwined networks, working in out-of-equilibrium conditions, which exhibit emergent properties, such as self-organization phenomena and chaotic behaviors in time and space.
| Author | : |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2002 |
| Genre | : Cells |
| ISBN | : 9780815332183 |
| Author | : Mark Deakin |
| Publisher | : Elsevier |
| Total Pages | : 416 |
| Release | : 2019-07-15 |
| Genre | : Computers |
| ISBN | : 0128154772 |
Untangling Smart Cities: From Theory to Practice helps all key stakeholders understand the complex and often conflicting nature of smart city research, offering valuable insights for designing and implementing strategies to improve the smart city decision-making processes. The book drives the reader to a better theoretical and practical comprehension of smart city development, beginning with a thorough and systematic analysis of the research literature published to date. The book provides an in-depth understanding of the entire smart city knowledge domain, revealing a deeply rooted division in its cognitive-epistemological structure as identified by bibliometric insights. Untangling Smart Cities fills the knowledge gap between theory and practice using case study research, with empirical evidence drawn from cities considered leaders in innovative smart city practices. An invaluable contribution to the growing scientific literature, Untangling Smart Cities provides an accurate and deep understanding of the strategic principles driving smart city development. Provides clarity on the smart city concepts and strategies Provides a systematic literature analysis on the state-of-the-art of Smart Cities research using bibliometrics combined with practical application to guide smart systems implementation Offers a comprehensive and systematic analysis of Smart Cities research produced during its first three decades, driven by statistical analysis techniques Generates a strong connection between theory and practice by providing the scientific knowledge necessary to approach the complex nature of Smart Cities sourced from the analysis of actual best practices Documents five main development pathways for smart cities development, serving the needs of city managers and policy makers with concrete advice and guidance
| Author | : Vincent T. DeVita |
| Publisher | : Lippincott Williams & Wilkins |
| Total Pages | : 6979 |
| Release | : 2018-11-16 |
| Genre | : Medical |
| ISBN | : 149639464X |
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Now updated online for the life of the edition, DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology, 11th Edition keeps you up to date in this fast-changing field. Every quarter, your eBook will be updated with late-breaking developments in oncology, including new drugs, clinical trials, and more.
| Author | : Vincent T DeVita Jr |
| Publisher | : Lippincott Williams & Wilkins |
| Total Pages | : 5443 |
| Release | : 2022-09-21 |
| Genre | : Medical |
| ISBN | : 1975184750 |
The standard-setting text in oncology for 40 years, DeVita, Hellman and Rosenberg’s Cancer: Principles and Practice of Oncology, 12th Edition, provides authoritative guidance and strategies for managing every type of cancer by stage and presentation. Drs. Vincent T. DeVita, Jr., Theodore S. Lawrence, and Steven A. Rosenberg oversee an outstanding team of expert contributing authors who keep you up to date and fully informed in this fast-changing field. This award-winning reference is also continually updated on Health Library and VitalSource platforms for the life of the edition.
| Author | : Ahamed Kutty |
| Publisher | : Page Publishing Inc |
| Total Pages | : 123 |
| Release | : 2020-01-29 |
| Genre | : Religion |
| ISBN | : 1645448444 |
Human beings generally attribute any physical, mental, or financial catastrophe to the random punitive decree of God, including death. All religions speak about destiny. In this book, I have demonstrated that whatever happens to us are determined by our genetic makeup and the DNA. Of course, the genes and DNA are created by God Himself who is the cause of all causations. In different religions, there is mention of an angel of death, whether this angels causes death or just receives the soul at the time of death is not clear. I have pointed out that natural cause of death is a function of the deteriorating telomere at the end of the chromosome. The other deaths due to accidents, epidemics, famine, and natural disasters are due to natural causes and is self-explanatory. I have mentioned the influence of epigenetics in our gene expression. The influence of epigenetics was recently confirmed in space travel as reported by NASA. This book also alludes to the fact that God does not interfere in our day-to-day activities and that is left for our free will.
| Author | : Stanley Maloy |
| Publisher | : Academic Press |
| Total Pages | : 4360 |
| Release | : 2013-03-03 |
| Genre | : Science |
| ISBN | : 0080961568 |
The explosion of the field of genetics over the last decade, with the new technologies that have stimulated research, suggests that a new sort of reference work is needed to keep pace with such a fast-moving and interdisciplinary field. Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set, builds on the foundation of the first edition by addressing many of the key subfields of genetics that were just in their infancy when the first edition was published. The currency and accessibility of this foundational content will be unrivalled, making this work useful for scientists and non-scientists alike. Featuring relatively short entries on genetics topics written by experts in that topic, Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set provides an effective way to quickly learn about any aspect of genetics, from Abortive Transduction to Zygotes. Adding to its utility, the work provides short entries that briefly define key terms, and a guide to additional reading and relevant websites for further study. Many of the entries include figures to explain difficult concepts. Key terms in related areas such as biochemistry, cell, and molecular biology are also included, and there are entries that describe historical figures in genetics, providing insights into their careers and discoveries. This 7-volume set represents a 25% expansion from the first edition, with over 1600 articles encompassing this burgeoning field Thoroughly up-to-date, with many new topics and subfields covered that were in their infancy or not inexistence at the time of the first edition. Timely coverage of emergent areas such as epigenetics, personalized genomic medicine, pharmacogenetics, and genetic enhancement technologies Interdisciplinary and global in its outlook, as befits the field of genetics Brief articles, written by experts in the field, which not only discuss, define, and explain key elements of the field, but also provide definition of key terms, suggestions for further reading, and biographical sketches of the key people in the history of genetics
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 3223 |
| Release | : 2013-01-08 |
| Genre | : Science |
| ISBN | : 0123786312 |
The 4-volume Encyclopedia of Biological Chemistry, Second Edition, represents the current state of a dynamic and crucial field of study. The Encyclopedia pulls together over 500 articles that help define and explore contemporary biochemistry, with content experts carefully chosen by the Editorial Board to assure both breadth and depth in its coverage. Editors-In-Chief William J. Lennarz and M. Daniel Lane have crafted a work that proceeds from the acknowledgement that understanding every living process-from physiology, to immunology, and genetics-is impossible without a grasp on the basic chemistry that provides its underpinning. Each article in the work provides an up-to-date snapshot of a given topic, written by experts, as well as suggestions for further readings for students and researcher wishing to go into greater depth. Available on-line via SciVerse ScienceDirect, the functionality of the Encyclopedia will provide easy linking to referenced articles, electronic searching, as well an online index and glossary to aid comprehension and searchability. This 4-volume set, thoroughly up-to-date and comprehensive, expertly captures this fast-moving field Curated by two esteemed editors-in-chief and an illustrious team of editors and contributors, representing the state of the field Suggestions for further readings offer researchers and students avenues for deeper exploration; a wide-ranging glossary aids comprehension
