Clinical and Translational Science

Clinical and Translational Science
Author: David Robertson
Publisher: Academic Press
Total Pages: 812
Release: 2016-11-25
Genre: Science
ISBN: 012802111X

Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Translational Medicine - What, Why and How: An International Perspective

Translational Medicine - What, Why and How: An International Perspective
Author: B. Alving
Publisher: Karger Medical and Scientific Publishers
Total Pages: 136
Release: 2012-12-21
Genre: Medical
ISBN: 3318022853

This book is the first to provide an aerial view, as well as detailed information, on ‘how’ activities in translational medicine are under development in countries such as the USA, China, the UK, and Taiwan. Institutions in each country are training investigators to work as sophisticated interdisciplinary teams. Investigators from 11 US academic health centers explain how they are incentivizing collaborations through pilot project programs, forming partnerships with business schools to promote efficient management of basic and clinical research, creating ethical, high-value public-private (industry) partnerships, improving efficiency with utilization of informatics, and engaging the community in research. The essential role of evaluation is explained in a clear and concise manner. The readers will also learn about the role of private funding in Taiwan and the vision of the government in China in developing multiple translational research centers. The UK is developing methodical approaches to patient needs across their lifespans; ongoing innovation is encouraged through incubator programs. With the emphasis on open innovation and sharing, the concepts and practice of translational medicine are spreading rapidly on an international scale.

From Auto- to Allotransplantation

From Auto- to Allotransplantation
Author: F.-C. Wei
Publisher: Karger Medical and Scientific Publishers
Total Pages: 190
Release: 2016-06-28
Genre: Medical
ISBN: 331805867X

This unique publication was written by experts who have made significant contributions to the development of reconstructive microsurgery and vascularized composite allotransplantation and are likely to shape its future. The book is divided into three major sections. The first presents the state-of-the-art of autologous microsurgical reconstruction. It summarizes current achievements, highlights the shortcomings of currently available techniques, and prepares the reader for the next evolutionary step: allotransplantation. Section two is a comprehensive review of allotransplantation, from immunology to surgical techniques. Finally, for those interested in establishing a comprehensive center for vascularized composite allotransplantation, section three provides important lessons from the successful Chang Gung Vascularized Composite Allotransplantation Center. From Auto- to Allotransplantation is indeed the only up-to-date and complete reference available on the topic. Scholars and research fellows interested in transplantation will benefit greatly from this work. It is also an invaluable resource for plastic, orthopedic, hand, ENT, oromaxillofacial, and general surgeons as well as for residents.

Biomaterials in Translational Medicine

Biomaterials in Translational Medicine
Author: Lei Yang
Publisher: Academic Press
Total Pages: 364
Release: 2018-11-30
Genre: Technology & Engineering
ISBN: 012813478X

Biomaterials in Translational Medicine delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine. - Systematically introduces the fundamental principles, rationales and methodologies of creating or improving biomaterials in the context of translational medicine - Includes the translational or commercialization status of these new biomaterials - Provides the reader with enough background knowledge for a fundamental grip of the difficulties and technicalities of using biomaterial translational medicine - Directs the reader on how to find other up-to-date sources (i.e. peer reviewed journals) in the field of translational medicine and biomaterials

Making Medical Knowledge

Making Medical Knowledge
Author: Miriam Solomon
Publisher:
Total Pages: 289
Release: 2015
Genre: Evidence-based medicine
ISBN: 0198732619

How is medical knowledge made? New methods for research and clinical care have reshaped the practices of medical knowledge production over the last forty years. Consensus conferences, evidence-based medicine, translational medicine, and narrative medicine are among the most prominent new methods. Making Medical Knowledge explores their origins and aims, their epistemic strengths, and their epistemic weaknesses. Miriam Solomon argues that the familiar dichotomy between the art and the science of medicine is not adequate for understanding this plurality of methods. The book begins by tracing the development of medical consensus conferences, from their beginning at the United States' National Institutes of Health in 1977, to their widespread adoption in national and international contexts. It discusses consensus conferences as social epistemic institutions designed to embody democracy and achieve objectivity. Evidence-based medicine, which developed next, ranks expert consensus at the bottom of the evidence hierarchy, thus challenging the authority of consensus conferences. Evidence-based medicine has transformed both medical research and clinical medicine in many positive ways, but it has also been accused of creating an intellectual hegemony that has marginalized crucial stages of scientific research, particularly scientific discovery. Translational medicine is understood as a response to the shortfalls of both consensus conferences and evidence-based medicine. Narrative medicine is the most prominent recent development in the medical humanities. Its central claim is that attention to narrative is essential for patient care. Solomon argues that the differences between narrative medicine and the other methods have been exaggerated, and offers a pluralistic account of how the all the methods interact and sometimes conflict. The result is both practical and theoretical suggestions for how to improve medical knowledge and understand medical controversies.

New Mentalities of Government in China

New Mentalities of Government in China
Author: David Bray
Publisher: Routledge
Total Pages: 299
Release: 2016-01-13
Genre: Political Science
ISBN: 131742235X

China continues to transform apace, flowing from the forces of deregulation, privatization and globalization unleashed by economic reforms which began in late 1978. The dramatic scope of economic change in China is often counterposed to the apparent lack of political change as demonstrated by continued Chinese Communist Party (CCP) rule. However, the ongoing dominance of the CCP belies the fact that much has also changed in relation to practices of government, including how authorities and citizens interact in the management of daily life. New Mentalities of Government in China examines how the privatization and professionalization of ‘public’ service provision is transforming the nature of government and everyday life in the People’s Republic of China (PRC). The book addresses key theoretical questions on the nature of government in China and documents the emergence of a range of ‘new mentalities of government’ in China. Its chapters focus on areas such as clinical trials, conceptualizing government, consumer activity, elite philanthropy, lifestyle and beauty advice, public health, social work, volunteering; and urban and rural planning. Offering a topical examination of shifting modes of governance in contemporary China, this book will appeal to scholars in the fields of anthropology, history, politics and sociology.

International Perspectives on Primary Care Research

International Perspectives on Primary Care Research
Author: Felicity Goodyear-Smith
Publisher: CRC Press
Total Pages: 278
Release: 2017-04-28
Genre: Medical
ISBN: 1351855484

International Perspectives on Primary Care Research examines how the evidence base from primary care research can strengthen health care services and delivery, tackle the growing burden of disease, improve quality and safety, and increase a person-centred focus to health care. Demonstrating the inter-professional nature of the discipline, the book also features a section on cross-nation organisations and primary care networks supporting research. National perspectives are offered from researchers in 20 countries that form part of the World Organization of Family Doctors, providing case histories from research-rich to resource-poor nations that illustrate the range of research development and capacity building. This book argues the importance of primary care research, especially to policy makers, decision makers and funders in informing best practice, training primary health care providers and achieving equitable distribution of care.

Shockwave Medicine

Shockwave Medicine
Author: C.-J. Wang
Publisher: Karger Medical and Scientific Publishers
Total Pages: 174
Release: 2018-04-05
Genre: Science
ISBN: 3318063134

This comprehensive reference work provides a detailed overview of shockwave therapy, a relatively new clinical specialty in modern medicine. It follows the evolution of Extracorporeal Shockwave Therapy (ESWT) from its initial stage as the gold standard for the disintegration of kidney stones to its regenerative effects in biological tissues. Starting with the basic principles of shockwave treatment, the book goes on to review its application in musculoskeletal disorders, including osteonecrosis of the hip, tendinopathy, fracture treatment, and treatment of sports related injuries. The application of ESWT in cardiovascular diseases is discussed. This includes preclinical and clinical applications for ischemic cardiovascular disease and effects on angiogenesis and anti-inflammation-molecular-cellular signaling pathways. The treatment of urinary diseases and erectile dysfunction by ESWT is elaborated. The book concludes with a discussion of future prospects of the shockwave therapy. Scholars and research fellows interested in shockwave medicine will benefit greatly from this work. It is also a useful clinical resource for nephrologists, urologists, cardiologists, and orthopedists.

U.S. Health in International Perspective

U.S. Health in International Perspective
Author: National Research Council
Publisher: National Academies Press
Total Pages: 421
Release: 2013-04-12
Genre: Social Science
ISBN: 0309264146

The United States is among the wealthiest nations in the world, but it is far from the healthiest. Although life expectancy and survival rates in the United States have improved dramatically over the past century, Americans live shorter lives and experience more injuries and illnesses than people in other high-income countries. The U.S. health disadvantage cannot be attributed solely to the adverse health status of racial or ethnic minorities or poor people: even highly advantaged Americans are in worse health than their counterparts in other, "peer" countries. In light of the new and growing evidence about the U.S. health disadvantage, the National Institutes of Health asked the National Research Council (NRC) and the Institute of Medicine (IOM) to convene a panel of experts to study the issue. The Panel on Understanding Cross-National Health Differences Among High-Income Countries examined whether the U.S. health disadvantage exists across the life span, considered potential explanations, and assessed the larger implications of the findings. U.S. Health in International Perspective presents detailed evidence on the issue, explores the possible explanations for the shorter and less healthy lives of Americans than those of people in comparable countries, and recommends actions by both government and nongovernment agencies and organizations to address the U.S. health disadvantage.

The Engaged Health Sciences Library Liaison

The Engaged Health Sciences Library Liaison
Author: Lindsay Alcock
Publisher: Rowman & Littlefield
Total Pages: 195
Release: 2020-05-15
Genre: Language Arts & Disciplines
ISBN: 1538126761

Liaison roles are generally commonplace in medical and health sciences libraries as librarians strive to develop and enhance relationships and collaborations with clinicians and faculty. While the liaison of the past acted primarily as the main contact between respective departments and the library providing a facilitative function (e.g. arranging for instruction sessions, inviting feedback on the collection, providing updates on new programs and services, etc.), today’s liaison activities are more proactive and robust. The Engaged Health Sciences Library Liaison features ten program descriptions that illustrate how the reach and scope of librarians in the medical/healthcare arena has changed dramatically since the inception of liaison services. The program outcomes described: illustrate a direct impact on curriculum development, address new information types with new access and preservation technologies, expand stakeholder groups, create research and teaching collaborations, and enhance functional roles. This authoritative book copublished by the Medical Library Association demonstrates thatcollaboration and communication, the basic tenets of a liaison program, breed innovative programs and services that are relevant, current, and valuable.