The Systemic Effects Of Advanced Cancer
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| Author | : Swarnali Acharyya |
| Publisher | : Springer Nature |
| Total Pages | : 198 |
| Release | : 2022-09-21 |
| Genre | : Medical |
| ISBN | : 3031095189 |
This textbook discusses the systemic consequences of cancer, covering a range of topics from tumor-promoting systemic effects to the development of cachexia, as summarized in the introductory chapter 1. Part I of this textbook focuses on tumor-promoting systemic effects and begins with a chapter on how tumor-derived extracellular vesicles and particles lay the foundation for future metastases (Chapter 2). Chapter 3 discusses how metastatic cells that have colonized the bone impact the local bone microenvironment, neighboring muscles, and host physiology. Chapter 4 summarizes the available strategies for targeting metastatic cancer and emphasizes the need to incorporate a systemic view of the disease. Following this overview of the systemic effects of cancer progression, Part II of the textbook discusses cancer-induced cachexia, a debilitating systemic effect of advanced cancer. Chapters 5-7 examine the key signaling pathways (interleukin-6/GP130, NF-kB, and muscle proteolysis) that drive the development of cancer cachexia. Chapters 8 and 9 in Part III of this textbook explore how toxicities from anti-cancer therapy are associated with the onset of cachexia in cancer patients, and provide insight into potential approaches to simultaneously target both cancer and cachexia. Chapters 10 and 11 (Part IV) conclude this textbook by outlining promising approaches for the diagnosis and treatment of cachexia as well as strategies to prevent the development of cachexia through exercise. An understanding of the systemic effects of cancer is essential for the design of effective anti-cancer and anti-cachexia treatment strategies. As such, this textbook provides key information for both students and scientists engaged in cancer research and oncology.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 455 |
| Release | : 2008-03-19 |
| Genre | : Medical |
| ISBN | : 0309134161 |
Cancer care today often provides state-of-the-science biomedical treatment, but fails to address the psychological and social (psychosocial) problems associated with the illness. This failure can compromise the effectiveness of health care and thereby adversely affect the health of cancer patients. Psychological and social problems created or exacerbated by cancer-including depression and other emotional problems; lack of information or skills needed to manage the illness; lack of transportation or other resources; and disruptions in work, school, and family life-cause additional suffering, weaken adherence to prescribed treatments, and threaten patients' return to health. Today, it is not possible to deliver high-quality cancer care without using existing approaches, tools, and resources to address patients' psychosocial health needs. All patients with cancer and their families should expect and receive cancer care that ensures the provision of appropriate psychosocial health services. Cancer Care for the Whole Patient recommends actions that oncology providers, health policy makers, educators, health insurers, health planners, researchers and research sponsors, and consumer advocates should undertake to ensure that this standard is met.
| Author | : Stephen Sonis |
| Publisher | : Academic Press |
| Total Pages | : 458 |
| Release | : 2019-09-14 |
| Genre | : Medical |
| ISBN | : 0128137630 |
Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care. Presents the work of leading international researchers and clinicians who speak on the clinical applications of genomics, proteomics, metabolomics, microbiomics, and epigenetics, as well as analytic methods and functional omics in oral medicine Provides full-color, richly illustrated chapters that examine systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease and autoimmune diseases Includes clinical case studies that illustrate examples of oral disease diagnostics and management, highlighting points of key importance for the reader Emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers, and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology, and primary care
| Author | : Kamal Dua |
| Publisher | : Elsevier |
| Total Pages | : 572 |
| Release | : 2021-06-24 |
| Genre | : Business & Economics |
| ISBN | : 0323900798 |
Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems
| Author | : |
| Publisher | : |
| Total Pages | : 44 |
| Release | : 1992 |
| Genre | : Cancer |
| ISBN | : |
| Author | : Antonio Macciò |
| Publisher | : Frontiers Media SA |
| Total Pages | : 104 |
| Release | : 2019-03-22 |
| Genre | : |
| ISBN | : 2889457710 |
The lack of recovery prospects in advanced cancer patients has often led to neglect important achievable therapeutic objectives, such as Quality of Life (QL) improvement, aimed at preserving, for as long as possible, patient integration with their family and social environment. In fact, traditional antineoplastic therapy protocols have been for a long time designed to demonstrate an advantage in clinical response and survival but have ignored essential supportive therapies and psychological and social well-being safeguard programs. Recent research of early integrated palliative care, including supportive care, aimed to obtain patient-centered therapeutic objectives. Noteworthy, advanced cancer patients often present a multiplicity of signs and symptoms responsible for physical impairment and reduction of functional abilities with consequent impossibility of carrying out the common daily activities. Additionally, the psycho-emotional integrity, the maintenance of family and social relationships and the spiritual issues contribute substantially to the optimal patients’ QL. Then, in the care of cancer patients their physical, psychological, social and spiritual needs should be globally addressed. In this context, cancer-related symptoms, which often occur in advanced stage cancer patients and can be either improved or worsened by the antineoplastic therapy, should be treated simultaneously with the planning and implementation of the most appropriate antineoplastic therapy. Therefore, any therapeutic approach should ideally be introduced within a context of the “best supportive care”, which includes optimal symptom management. To obtain this scope, the knowledge and awareness of the biological specificity of the disease and patient psychosocial interactions can no longer be considered optional by the multidisciplinary medical team in charge. To date, many of the mechanisms at the basis of the pathogenesis of many cancer-related symptoms are far from being fully understood. Consequently, an effective treatment is yet lacking and represent an unmet need in oncology clinical practice. This Research Topic includes articles in the field of biochemical, and molecular investigations, physiological and clinical studies related to the pathogenesis and potential targeted approaches of some important cancer signs and symptoms. We focused on cachexia, anorexia, muscle wasting, osteopenia, cancer-related anemia, physical inactivity and fatigue. The Research Topic includes Original Research, Review and Perspective articles.
| Author | : Simon S. Lo |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 433 |
| Release | : 2012-08-28 |
| Genre | : Medical |
| ISBN | : 364225604X |
Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.
| Author | : Egidio Del Fabbro |
| Publisher | : Springer |
| Total Pages | : 88 |
| Release | : 2015-04-02 |
| Genre | : Medical |
| ISBN | : 1910315079 |
Cancer Cachexia is a concise, fully illustrated handbook written with the aim of increasing awareness of cancer cachexia and highlighting best practice diagnosis, treatment, and management options for this devastating disorder. This is another title in the ongoing Springer Healthcare Cancer Supportive Care Series.
| Author | : Paul Glare |
| Publisher | : Oxford University Press |
| Total Pages | : 452 |
| Release | : 2008-03-20 |
| Genre | : Medical |
| ISBN | : 0198530226 |
In order to make decisions and offer quality health care, it is essential to be able to predict survival and other outcomes. This practical, evidence-based book brings together prognosis information for patients with advanced cancer.
| Author | : |
| Publisher | : |
| Total Pages | : 34 |
| Release | : 2000 |
| Genre | : Cancer |
| ISBN | : |
