The Synthesis Of Potential Serine Protease Inhibitors
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A New Class of Serine and Cysteine Protease Inhibitor with Chemotherapeutic Potential
| Author | : |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 1999 |
| Genre | : |
| ISBN | : |
Metastasis and angiogenesis in cancer are dependent on a variety of biologically active compounds including serine protease. Inhibition of proteases such as plasmin is a potential route for suppression of both metastasis and angiogenesis. Synthesis of tetrahydrothiopyran-4-one based inhibitors containing either a dialkylamino chain, a lysine analog side chain and a dipeptide (D-ile-phe or D-ile-Trp), or just the D-ile-phe dipeptide was accomplished. A compound with both the lysine analog side chain and the dipeptide but lacking a carbonyl was also produced.
Design, Synthesis, and Structure-activity Relationships Analysis of Potential Inhibitors of the Serine Protease Thrombin and the Malarial Aspartic Proteases Plasmepsin I and II
| Author | : Anders Dahlgren |
| Publisher | : |
| Total Pages | : 58 |
| Release | : 2002 |
| Genre | : |
| ISBN | : 9789173734486 |
Design and Synthesis of a Potential Inhibitor for DEN2 NS2B/NS3 Serine Protease
| Author | : Yean Kee Lee |
| Publisher | : |
| Total Pages | : 268 |
| Release | : 2011 |
| Genre | : Antiviral agents |
| ISBN | : |
Activation of Viruses by Host Proteases
| Author | : Eva Böttcher-Friebertshäuser |
| Publisher | : Springer |
| Total Pages | : 337 |
| Release | : 2018-05-22 |
| Genre | : Medical |
| ISBN | : 3319754742 |
This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.
