The Mutagenicity Of Pesticides
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The Mutagenicity of Pesticides
Author | : Samuel S. Epstein |
Publisher | : MIT Press (MA) |
Total Pages | : 248 |
Release | : 1971 |
Genre | : Chemical mutagenesis |
ISBN | : |
This is the first book to present recently developed mammalian methodologies for evaluating mutagenic hazards of chemicals such as pesticides.
Mutagenicity: Assays and Applications
Author | : Ashutosh Kumar |
Publisher | : Academic Press |
Total Pages | : 352 |
Release | : 2017-09-26 |
Genre | : Science |
ISBN | : 0128092602 |
Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. Presents an up-to-date and in-depth review of the current state of mutagenesis research Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials
Criteria for Evaluating the Mutagenicity of Chemicals
Author | : United States. Environmental Protection Agency. Office of Pesticide Programs |
Publisher | : |
Total Pages | : 30 |
Release | : 1977 |
Genre | : Mutagenicity testing |
ISBN | : |
Chemical Mutagens
Author | : Alexander Hollaender |
Publisher | : Springer Science & Business Media |
Total Pages | : 410 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1461589665 |
As editor I want especially to thank Dr. Ernst Freese for helpful co operation in preparing these volumes, and to express my appreclatlOn to Drs. Kurt Hirschhorn and Marvin Legator, the other members of the editorial board. Alexander Hollaender January 1971 Preface The purpose of these volumes is to encourage the development and ap plication of testing and monitoring procedures to avert significant human exposure to mutagenic agents. The need for protection against exposure to possibly mutagenic chemicals is only now coming to be generally realized. The recently issued Report of the Secretary's Commission on Pesticides and Their Possible Effects on Health (the Mrak Report-U.S. Department of Health, Education and Welfare, December 1969) has made an important start. Its Panel on Mutagenicity recommends that all currently used pesticides be tested for mutagenicity in several recently developed and relatively simple systems. Whether recommendations such as these are actually put into effect will depend on convincing government, industry, and the public that the problem is important, that the proposed tests would be effective, and that they can be conducted at a cost that is not prohibitive. Why is it important to screen environmental agents for mutagenic activity? To those who will read this book, the answer is self-evident. The sine qua non of all that we value and all that we are is our genetic heritage.
Pesticides in the Diets of Infants and Children
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 402 |
Release | : 1993-02-01 |
Genre | : Science |
ISBN | : 0309048753 |
Many of the pesticides applied to food crops in this country are present in foods and may pose risks to human health. Current regulations are intended to protect the health of the general population by controlling pesticide use. This book explores whether the present regulatory approaches adequately protect infants and children, who may differ from adults in susceptibility and in dietary exposures to pesticide residues. The committee focuses on four major areas: Susceptibility: Are children more susceptible or less susceptible than adults to the effects of dietary exposure to pesticides? Exposure: What foods do infants and children eat, and which pesticides and how much of them are present in those foods? Is the current information on consumption and residues adequate to estimate exposure? Toxicity: Are toxicity tests in laboratory animals adequate to predict toxicity in human infants and children? Do the extent and type of toxicity of some chemicals vary by species and by age? Assessing risk: How is dietary exposure to pesticide residues associated with response? How can laboratory data on lifetime exposures of animals be used to derive meaningful estimates of risk to children? Does risk accumulate more rapidly during the early years of life? This book will be of interest to policymakers, administrators of research in the public and private sectors, toxicologists, pediatricians and other health professionals, and the pesticide industry.
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 471: Bacterial Reverse Mutation Test
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 12 |
Release | : 1997-07-21 |
Genre | : |
ISBN | : 9264071245 |
The bacterial reverse mutation test uses amino-acid requiring at least five strains of Salmonella typhimurium and Escherichia coli to detect point mutations by base substitutions or frameshifts. The principle of this bacterial reverse mutation test ...
Organophosphates Chemistry, Fate, and Effects
Author | : Janice E. Chambers |
Publisher | : Elsevier |
Total Pages | : 462 |
Release | : 2013-10-22 |
Genre | : Medical |
ISBN | : 0080917267 |
This volume pulls together a wealth of up-to-date information on the toxicology of this diverse and ubiquitous class of insecticides. Leading experts review the reactivity of organophosphorus compounds with cholinesterase, as well as their metabolism and biological effects on humans and other nontarget organisms. The book not only covers the anticholinesterase actions of organophosphates, but also other, presumably independent, effects, such as teratogenicity, delayed neuropathy, immunotoxicity, and behavioral toxicity. Offers crucial overviews of chemical and biochemical reactivity and biological responsiveness of mainly nontarget organisms Reviews new developments in assessment of metabolism and disposition of organophosphorus compounds Examines organophosphorus compound-induced toxicity mediated by mechanisms other than inhibition of acetylcholinesterase Covers new research on differences in toxicity induced by the variety of organophosphorus Analyzes current controversies on the relevance of certain biochemical parameters in actual organophosphate toxicity in vivo