The Metabolism Of Drugs And Other Xenobiotics
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| Author | : Pavel Anzenbacher |
| Publisher | : John Wiley & Sons |
| Total Pages | : 755 |
| Release | : 2012-05-29 |
| Genre | : Medical |
| ISBN | : 352732903X |
A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.
| Author | : Pavel Anzenbacher |
| Publisher | : John Wiley & Sons |
| Total Pages | : 755 |
| Release | : 2012-02-23 |
| Genre | : Medical |
| ISBN | : 3527646329 |
A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.
| Author | : Costas Ioannides |
| Publisher | : John Wiley & Sons |
| Total Pages | : 600 |
| Release | : 2002 |
| Genre | : Medical |
| ISBN | : |
This reference work focuses on the enzyme systems that participate in the metabolism of chemicals and other xenobiotics, with emphasis being placed on drug metabolism. Each chapter focuses on a specific enzyme system.
| Author | : |
| Publisher | : |
| Total Pages | : 26 |
| Release | : 19?? |
| Genre | : Drugs |
| ISBN | : |
| Author | : Bernard Testa |
| Publisher | : John Wiley & Sons |
| Total Pages | : 808 |
| Release | : 2003-08 |
| Genre | : Science |
| ISBN | : 9783906390253 |
Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.
| Author | : Costas Ioannides |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 584 |
| Release | : 2008 |
| Genre | : Medical |
| ISBN | : 0854042741 |
With contributions by a team of internationally respected scientists, this book provides up-to-date information on the extensively studied cytochrome P450 enzyme in a very accessible manner.
| Author | : Bernard Testa |
| Publisher | : |
| Total Pages | : 471 |
| Release | : 1995 |
| Genre | : Drugs |
| ISBN | : 9780100737488 |
| Author | : Corina Ionescu |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 444 |
| Release | : 2006-02-28 |
| Genre | : Medical |
| ISBN | : 9781402041419 |
Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
| Author | : Grace S. N. Lau |
| Publisher | : Chinese University Press |
| Total Pages | : 344 |
| Release | : 1997 |
| Genre | : Acetaminophen |
| ISBN | : 9789622017443 |
'The metabolic activation of many drugs and xenobiotics in vivo is effected through the large family of cytochrome P450s enzymes that catalyse a diverse spectrum of reactions including the metabolism of both endogenous and exogenous compounds. There is considerable evidence suggesting that changes in P450 activities can affect the in vivo toxicity of drugs in both animals and humans. Oxidative metabolism by cytochrome P450 enzymes has been implicated in the pathogenesis of cancer, through the formation of toxic intermediates and carcinogenic metabolites are formed from drugs and xenobiotics. A marked overall increase in the metabolic activation of the commonly used analgesic agent, paracetamol, was found in patients with hepatocellular carcinoma, as indicated by a much higher percentage recovery of the oxidative metabolites cysteine and mercapturate conjugates, compared to healthy controls and patients with chronic hepatitis B infection. It was through that metabolic activation of some drugs and xenobiotics through the actions of specific cytochrome P450s may be enhanced in patients with hepatocellular carcinoma.
| Author | : International Society for the Study of Xenobiotics |
| Publisher | : Taylor & Francis Group |
| Total Pages | : 400 |
| Release | : 1988 |
| Genre | : Medical |
| ISBN | : |
