The Journal Of Experimental Medicine Volume 10
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| Author | : Marie-Caroline Dieu-Nosjean |
| Publisher | : Humana Press |
| Total Pages | : 289 |
| Release | : 2018-09-05 |
| Genre | : Medical |
| ISBN | : 9781493987085 |
This volume explores the various methods used to study tertiary lymphoid structures (TLS) in pathological situations. Pre-clinical models are also discussed in detail to show how TLS structure, development, and maintenance can be targeted and studied in vivo. The chapters in this book cover topics such as humans and mice; strategies to quantify TLS in order to use it in stained tissue sections; classifying a gene signature form fixed and paraffin-embedded tissues; and development of murine inflammatory models to help look at TLS in the context of infection or malignancy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Tertiary Lymphoid Structures: Methods and Protocols is a valuable resource that increases the reader’s knowledge on immune functions and how they will pave the way to future therapeutic applications.
| Author | : Rockefeller Institute for Medical Res |
| Publisher | : Legare Street Press |
| Total Pages | : 0 |
| Release | : 2023-07-18 |
| Genre | : |
| ISBN | : 9781022740655 |
The Journal of Experimental Medicine is a peer-reviewed medical journal that publishes original research in the field of medicine. It is one of the oldest and most prestigious medical journals in the world and has been publishing groundbreaking research since 1896. The journal is produced by the Rockefeller University and covers a range of topics in medicine, including immunology, infectious disease, cancer, and genetics. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
| Author | : Randy Q. Cron |
| Publisher | : Springer Nature |
| Total Pages | : 607 |
| Release | : 2019-09-09 |
| Genre | : Medical |
| ISBN | : 303022094X |
Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals. A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder – from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors, and treatment.
| Author | : Ayse Basak Engin |
| Publisher | : Springer |
| Total Pages | : 618 |
| Release | : 2017-06-05 |
| Genre | : Science |
| ISBN | : 331948382X |
Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.
| Author | : Rockefeller University |
| Publisher | : |
| Total Pages | : 734 |
| Release | : 1910 |
| Genre | : Medicine |
| ISBN | : |
| Author | : Rockefeller Institute for Medical Research |
| Publisher | : |
| Total Pages | : 658 |
| Release | : 1910 |
| Genre | : Medicine |
| ISBN | : |
| Author | : Bi-Cheng Liu |
| Publisher | : Springer |
| Total Pages | : 707 |
| Release | : 2019-08-09 |
| Genre | : Science |
| ISBN | : 9811388717 |
This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.
| Author | : Xiaochu Zhang |
| Publisher | : Springer |
| Total Pages | : 357 |
| Release | : 2017-11-02 |
| Genre | : Medical |
| ISBN | : 9811055629 |
This book focuses on the similarities and differences between substance and non-substance addictions. It discusses in detail the mechanisms, diagnosis and treatment of substance and non-substance addictions, and addresses selected prospects that will shape future studies on addiction. Addiction is a global problem that costs millions of lives tremendous damage year after year. There are mainly two types of addition: substance addiction (e.g., nicotine, alcohol, cannabis, heroin, stimulants, etc.) and non-substance addiction (e.g., gambling, computer gaming, Internet, etc.). Based on existing evidence, both types of addiction produce negative impacts on individuals’ physical, mental, social and financial well-being, and share certain common mechanisms, which involve a dysfunction of the neural reward system and specific gene transcription factors. However, there are also key differences between these two types of addiction. Covering these aspects systematically, the book will provide researchers and graduate students alike a better understanding of drug and behavioral addictions.
| Author | : |
| Publisher | : |
| Total Pages | : 620 |
| Release | : 1921 |
| Genre | : Electronic journals |
| ISBN | : |
| Author | : N. B. Myant |
| Publisher | : Butterworth-Heinemann |
| Total Pages | : 925 |
| Release | : 2014-04-24 |
| Genre | : Science |
| ISBN | : 148328123X |
The Biology of Cholesterol and Related Steroids focuses on the study of sterols in relation to living organisms. The publication first takes a look at the analysis of sterols and related steroids and the distribution of sterols and related steroids in nature, as well as the processes of extraction and separation and presence of sterols in plants, fungi, vertebrates, and invertebrates. The text then ponders on biosynthesis of sterols and metabolism of cholesterol. Topics include formation of fatty acid esters of cholesterol, steroid hormones, biosynthetic pathway to sterols, reaction mechanisms, and comparative aspects of sterol synthesis. The manuscript examines the developmental aspects of cholesterol metabolism and sterols in biological membranes. The book also reviews cholesterol synthesis in animal tissues, sterol metabolism in isolated cells, and epidemiology of the plasma cholesterol. Discussions focus on selection of statistical populations, genetic influences, regulation of sterol synthesis, general aspects of sterol metabolism, and removal of cell cholesterol in vivo. The publication is a dependable source of data for biochemists and readers interested in the biology of cholesterol and steroids.
