Biological Inorganic Chemistry

Biological Inorganic Chemistry
Author: Robert R. Crichton
Publisher: Elsevier
Total Pages: 383
Release: 2007-12-11
Genre: Science
ISBN: 0080556221

The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. The present text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of the concepts, both chemical and biological, which are required to equip the reader for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis are dealt with next. Thereafter, individual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finally molybdenum, vanadium, tungsten and chromium. The final three chapters provide a tantalising view of the roles of metals in brain function, biomineralization and a brief illustration of their importance in both medicine and the environment.Relaxed and agreeable writing style. The reader will not only fiind the book easy to read, the fascinating anecdotes and footnotes will give him pegs to hang important ideas on.Written by a biochemist. Will enable the reader to more readily grasp the biological and clinical relevance of the subject.Many colour illustrations. Enables easier visualization of molecular mechanismsWritten by a single author. Ensures homgeneity of style and effective cross referencing between chapters

Practical Approaches to Biological Inorganic Chemistry

Practical Approaches to Biological Inorganic Chemistry
Author: Robert R. Crichton
Publisher: Elsevier
Total Pages: 506
Release: 2019-09-10
Genre: Science
ISBN: 0444642269

Practical Approaches to Biological Inorganic Chemistry, Second Edition, reviews the use of spectroscopic and related analytical techniques to investigate the complex structures and mechanisms of biological inorganic systems that contain metals. Each chapter presents an overview of the technique, including relevant theory, a clear explanation of what it is, how it works, and how the technique is actually used to evaluate biological structures. New chapters cover Raman Spectroscopy and Molecular Magnetochemistry, but all chapters have been updated to reflect the latest developments in discussed techniques. Practical examples, problems and many color figures are also included to illustrate key concepts. The book is designed for researchers and students who want to learn both the basics and more advanced aspects of key methods in biological inorganic chemistry. - Presents new chapters on Raman Spectroscopy and Molecular Magnetochemistry, as well as updated figures and content throughout - Includes color images throughout to enable easier visualization of molecular mechanisms and structures - Provides worked examples and problems to help illustrate and test the reader's understanding of each technique - Written by leading experts who use and teach the most important techniques used today to analyze complex biological structures

Biological Inorganic Chemistry

Biological Inorganic Chemistry
Author: Ivano Bertini
Publisher: University Science Books
Total Pages: 794
Release: 2007
Genre: Science
ISBN: 9781891389436

Part A.: Overviews of biological inorganic chemistry : 1. Bioinorganic chemistry and the biogeochemical cycles -- 2. Metal ions and proteins: binding, stability, and folding -- 3. Special cofactors and metal clusters -- 4. Transport and storage of metal ions in biology -- 5. Biominerals and biomineralization -- 6. Metals in medicine. -- Part B.: Metal ion containing biological systems : 1. Metal ion transport and storage -- 2. Hydrolytic chemistry -- 3. Electron transfer, respiration, and photosynthesis -- 4. Oxygen metabolism -- 5. Hydrogen, carbon, and sulfur metabolism -- 6. Metalloenzymes with radical intermediates -- 7. Metal ion receptors and signaling. -- Cell biology, biochemistry, and evolution: Tutorial I. -- Fundamentals of coordination chemistry: Tutorial II.

The Inorganic Chemistry of Biological Processes

The Inorganic Chemistry of Biological Processes
Author: M. N. Hughes
Publisher:
Total Pages: 362
Release: 1981-05-06
Genre: Science
ISBN:

A survey of the occurrence and role of metal ions in biological processes and how they may be studied experimentally. Provides a summary of relevant biology, and properties of transition metal complexes and the mechanisms of their reactions in solution. Discusses the role of platinum complexes in cancer chemotherapy. Features extensive rewriting in light of recent advances, and new material on transport and storage of iron, and on non-metals.

Inorganic Chemical Biology

Inorganic Chemical Biology
Author: Gilles Gasser
Publisher: John Wiley & Sons
Total Pages: 437
Release: 2014-06-23
Genre: Science
ISBN: 111851002X

Understanding, identifying and influencing the biological systems are the primary objectives of chemical biology. From this perspective, metal complexes have always been of great assistance to chemical biologists, for example, in structural identification and purification of essential biomolecules, for visualizing cellular organelles or to inhibit specific enzymes. This inorganic side of chemical biology, which continues to receive considerable attention, is referred to as inorganic chemical biology. Inorganic Chemical Biology: Principles, Techniques and Applications provides a comprehensive overview of the current and emerging role of metal complexes in chemical biology. Throughout all of the chapters there is a strong emphasis on fundamental theoretical chemistry and experiments that have been carried out in living cells or organisms. Outlooks for the future applications of metal complexes in chemical biology are also discussed. Topics covered include: • Metal complexes as tools for structural biology • IMAC, AAS, XRF and MS as detection techniques for metals in chemical biology • Cell and organism imaging and probing DNA using metal and metal carbonyl complexes • Detection of metal ions, anions and small molecules using metal complexes • Photo-release of metal ions in living cells • Metal complexes as enzyme inhibitors and catalysts in living cells Written by a team of international experts, Inorganic Chemical Biology: Principles, Techniques and Applications is a must-have for bioinorganic, bioorganometallic and medicinal chemists as well as chemical biologists working in both academia and industry.

Bioinorganic Chemistry -- Inorganic Elements in the Chemistry of Life

Bioinorganic Chemistry -- Inorganic Elements in the Chemistry of Life
Author: Wolfgang Kaim
Publisher: John Wiley & Sons
Total Pages: 436
Release: 2013-10-14
Genre: Science
ISBN: 0470975237

The field of Bioinorganic Chemistry has grown significantly in recent years; now one of the major sub-disciplines of Inorganic Chemistry, it has also pervaded other areas of the life sciences due to its highly interdisciplinary nature. Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life, Second Edition provides a detailed introduction to the role of inorganic elements in biology, taking a systematic element-by-element approach to the topic. The second edition of this classic text has been fully revised and updated to include new structure information, emerging developments in the field, and an increased focus on medical applications of inorganic compounds. New topics have been added including materials aspects of bioinorganic chemistry, elemental cycles, bioorganometallic chemistry, medical imaging and therapeutic advances. Topics covered include: Metals at the center of photosynthesis Uptake, transport, and storage of essential elements Catalysis through hemoproteins Biological functions of molybdenum, tungsten, vanadium and chromium Function and transport of alkaline and alkaline earth metal cations Biomineralization Biological functions of the non-metallic inorganic elements Bioinorganic chemistry of toxic metals Biochemical behavior of radionuclides and medical imaging using inorganic compounds Chemotherapy involving non-essential elements This full color text provides a concise and comprehensive review of bioinorganic chemistry for advanced students of chemistry, biochemistry, biology, medicine and environmental science.

The Biological Chemistry of the Elements

The Biological Chemistry of the Elements
Author: J. J. R. Fraústo da Silva
Publisher: Oxford University Press
Total Pages: 561
Release: 1993
Genre: Biochemistry
ISBN: 9780198558026

The study of the chemistry of living processes has traditionally centered on the behavior of organic compounds in water - together they account for 99% of the matter in living systems. However, we also know that about twenty `inorganic' elements are also essential for life, and that they are found in similar amounts in most living systems. The authors' objective in this book is to examine and explain the importance of these elements by `bringing inorganic chemistry to life'. The authors commence with a survey of the chemical and physical factors controlling the elements of life; the essential functions of individual inorganic elements are then described in detail. A final section consolidates a major theme of the book - the cooperative interaction of elements in living systems. These chapters examine the relationships between chemical activity and morphology and the effect that changes in the availability of elements have on life - not only in providing evolutionary pressures but also in the context of the use of medicines and the spread of pollutants.

Physical Methods in Bioinorganic Chemistry

Physical Methods in Bioinorganic Chemistry
Author: Lawrence Que
Publisher: Sterling Publishing Company
Total Pages: 574
Release: 2000
Genre: Science
ISBN: 9781891389023

This text provides detailed coverage of physical methods used in bioinorganic chemistry. By integrating theory with experimentation, and providing a more biological orientation, the book aims to serve as a major textbook for students of bioinorganic chemistry.

Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells

Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells
Author: Kenneth Kam-Wing Lo
Publisher: Academic Press
Total Pages: 408
Release: 2016-12-30
Genre: Science
ISBN: 012803887X

Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells provides a complete overview of this important research area that is perfect for both newcomers and expert researchers in the field. Through concise chapters written and edited by esteemed experts, this book brings together a comprehensive treatment of the area previously only available through scattered, lengthy review articles in the literature. Advanced topics of research are covered, with particular focus on recent advances in the biological applications of transition metal complexes, including inorganic medicine, enzyme inhibitors, antiparasital agents, and biological imaging reagents. - Geared toward researchers and students who seek an introductory overview of the field, as well as researchers working in advanced areas - Focuses on the interactions of inorganic and organometallic transition metal complexes with biological molecules and live cells - Foscuses on the fundamentals and their potential therapeutic and diagnostic applications - Covers recent biological applications of transition metal complexes, such as anticancer drugs, enzyme inhibitors, bioconjugation agents, chemical biology tools, and bioimaging reagents