The Flaviviruses Structure Replication And Evolution
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| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 403 |
| Release | : 2003-12-18 |
| Genre | : Science |
| ISBN | : 0080493815 |
Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Structure, Replication and Evolution is the first volume of The Flaviviruses and presents the latest research covering the conceptual advances on aspects such as the characterization of virus structure, cellular receptors, mechanisms of virus entry, host and viral components of the RNA replicase. - Includes new, detailed information on the evolution, viral structure and replication of the Flavivirus family - The only complete reference book on a major virus family - Descibes the technologies that have contributed to our current knowledge about Flaviviruses - Identifies the major problems faced in understanding the virus-host interactions that result in disease
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 607 |
| Release | : 2003-12-18 |
| Genre | : Medical |
| ISBN | : 0080493831 |
Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Detection, Diagnosis and Vaccine Development, the third volume of The Flaviviruses details the current status of technologies for detection and differentiation of these viruses, their use in surveillance and outbreak investigation, and also reviews the latest clinical research. - Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions - Descibes the technologies that have contributed to our current knowledge about the Flaviviruses - Identifies the major problems faced in understanding the virus-host interactins that result in disease - An exhaustive compendium of current and past knowledge on the Flavivirus family
| Author | : Sondra Schlesinger |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 464 |
| Release | : 2013-03-09 |
| Genre | : Medical |
| ISBN | : 1475707851 |
The publication of this volume of The Viruses entitled The Togaviridae and Flaviviridae comes at an appropriate time. The structure and rep lication strategies of these viruses are now known to be sufficiently di verse to warrant the removal of flaviviruses from the Togaviridae family and establish them as an independent family. Flaviviridae have a special place in the history of virology. The prototype virus-yellow fever virus was the first virus to be identified as the cause of a human disease. Some of the history of this discovery is described in Chapter 1 of this volume; in Chapter 10 the complete sequence of the RNA genome of the virus is presented. This sequence not only defines the primary structure of the viral proteins, it also clarifies the mechanism of translation of the fla vivirus genome. Knowledge of the sequence of the structural proteins of these viruses represents an important step in the potential goal of using purified flavivirus glycoproteins as vaccines. Many of the chapters in this volume focus on the structure and replication of the Togaviridae. These viruses have provided valuable models for studies in cell biology, partic ularly with regard to the cotranslational and posttranslational steps re quired for the synthesis and localization of membrane glycoproteins. Fur thermore, Togaviridae have been pivotal in our growing understanding of how enveloped viruses enter and exit from cells. The broad outlines of the structure and gene expression of Togavir idae and Flaviviridae are known, but important questions remain.
| Author | : Walter R Schlesinge |
| Publisher | : Elsevier |
| Total Pages | : 704 |
| Release | : 2012-12-02 |
| Genre | : Science |
| ISBN | : 0323138268 |
The Togaviruses: Biology, Structure, Replication deals with the biology, structure, and replication of rotaviruses. This book covers topics such as the biochemistry of rotaviruses and the biological and medical challenges they pose. It also gives an account of their mechanisms of replication that might lead to perceptions of the capacity to solve biological and epidemiological problems through the concepts and technology of molecular biology. This text is comprised of 21 chapters that explore clinical details, routine procedures for diagnostic virus isolation and identification and for serological tests; immunological host responses; the role of interferons; antiviral chemotherapy; and vaccine development. The discussion begins with a historical overview of arboviruses, followed by a description of all the viruses that belong to Togaviridae. These include alpha- and flaviviruses, rubiviruses, pestiviruses, and other ""non-arbo"" togaviruses. The next chapters focus on the arthropod-vertebrate-arthropod transmission cycle and its experimental equivalents, along with the viruses' structure, composition, and replication. This book concludes with a summary of physicochemical, morphological, and clinical data on non-arbo togaviruses. This reference material will be of interest to physicians, veterinarians, ecologists, entomologists, epidemiologists, cell biologists, immunologists, virologists, physical chemists, biochemists, molecular biologists, and geneticists.
| Author | : Esteban Domingo |
| Publisher | : Elsevier |
| Total Pages | : 573 |
| Release | : 2008-06-23 |
| Genre | : Science |
| ISBN | : 0080564968 |
New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases. - NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution - UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups - SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts
| Author | : Jan Gorodkin |
| Publisher | : Humana |
| Total Pages | : 0 |
| Release | : 2014-03-18 |
| Genre | : Science |
| ISBN | : 9781627037082 |
The existence of genes for RNA molecules not coding for proteins (ncRNAs) has been recognized since the 1950's, but until recently, aside from the critically important ribosomal and transfer RNA genes, most focus has been on protein coding genes. However, a long series of striking discoveries, from RNA's ability to carry out catalytic function, to discovery of riboswitches, microRNAs and other ribo-regulators performing critical tasks in essentially all living organisms, has created a burgeoning interest in this primordial component of the biosphere. However, the structural characteristics and evolutionary constraints on RNA molecules are very different from those of proteins, necessitating development of a completely new suite of informatic tools to address these challenges. In RNA Sequence, Structure, Function: Computational and Bioinformatic Methods, expert researchers in the field describe a substantial and relevant fraction of these methodologies from both practical and computational/algorithmic perspectives. Focusing on both of these directions addresses both the biologist interested in knowing more about RNA bioinformatics as well as the bioinformaticist interested in more detailed aspects of the algorithms. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results. Thorough and intuitive, RNA Sequence, Structure, Function: Computational and Bioinformatic Methods aids scientists in continuing to study key methods and principles of RNA bioinformatics.
| Author | : Pei-Yong Shi |
| Publisher | : Caister Academic Press Limited |
| Total Pages | : 0 |
| Release | : 2012 |
| Genre | : Medical |
| ISBN | : 9781904455929 |
Flaviviruses are a diverse group of small RNA enveloped viruses, many of which are important human and animal pathogens. The best known include dengue virus, yellow fever virus, Japanese encephalitis virus, and West Nile virus. These viruses are endemic in many tropical and sub-tropical regions of the world. Dengue virus alone infects over 100 million people annually. In recent years, research on flaviviruses has progressed at a remarkable rate, leading to significant advances in our understanding of virus biology. This should ultimately lead to the development of better vaccine and antiviral strategies. This up-to-date and cutting-edge anthology contains contributions from the leading experts in the flavivirus field. Chapters are balanced by contributions from established investigators who have dedicated their careers to flavivirus research with those from newcomers who have recently made significant contributions to the flavivirus field. The book is divided into two sections: Molecular Virology and Virus Prevention. The first section on Molecular Virology covers: virion structure * virus replication * the NS1 glycoprotein * the NS3 protein * the NS5 protein * innate immunity and flavivirus infection * host responses to flavivirus infection * flavivirus fitness and transmission. The Virus Prevention section includes: vaccines * antibody therapy * small molecule antiviral development * flavivirus diagnostics * vector-virus interactions * vector control. The book represents an important update of flavivirus research and will serve as a reference to flavivirus researchers at the graduate level and beyond. It is a recommended text for all virology libraries.
| Author | : Esteban Domingo |
| Publisher | : Academic Press |
| Total Pages | : 428 |
| Release | : 2019-11-06 |
| Genre | : Science |
| ISBN | : 0128163321 |
Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included. The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere. - Features current views on key steps in the origin of life and origins of viruses - Includes examples relating ancestral features of viruses with their current adaptive capacity - Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read - Considers quasispecies as a framework to understand virus adaptability and disease processes
| Author | : Manja Marz |
| Publisher | : MDPI |
| Total Pages | : 330 |
| Release | : 2020-02-21 |
| Genre | : Science |
| ISBN | : 3039218824 |
Virus bioinformatics is evolving and succeeding as an area of research in its own right, representing the interface of virology and computer science. Bioinformatic approaches to investigate viral infections and outbreaks have become central to virology research, and have been successfully used to detect, control, and treat infections of humans and animals. As part of the Third Annual Meeting of the European Virus Bioinformatics Center (EVBC), we have published this Special Issue on Virus Bioinformatics.
| Author | : John Mackenzie |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 423 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642594034 |
Japanese encephalitis and West Nile viruses are members of the Japanese encephalitis serological group of the genus Flavivirus and therefore closely related genetically and antigenically. They share a number of properties, including the use of birds as their major wildlife maintenance host and Culicine mosquitoes for transmission, and they are both associated with severe human disease, as well as fatal infections in horses. The emergence of these two viruses, and their well-established propensity to colonise new areas, make it timely to re-examine their ecology, biology, molecular structure, replication and epidemiology, and these therefore provide the focus of this volume.
