The Endocannabinoid System: Filling the Translational Gap between Neuroscience and Psychiatry
| Author | : Marco Colizzi |
| Publisher | : Frontiers Media SA |
| Total Pages | : 139 |
| Release | : 2022-01-24 |
| Genre | : Medical |
| ISBN | : 2889741486 |
The Endocannabinoid System Filling The Translational Gap Between Neuroscience And Psychiatry
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Cannabinoid Modulation of Emotion, Memory, and Motivation
| Author | : Patrizia Campolongo |
| Publisher | : Springer |
| Total Pages | : 469 |
| Release | : 2015-05-18 |
| Genre | : Medical |
| ISBN | : 1493922947 |
The endocannabinoid system consists of cannabinoid receptors, their endogenous lipid ligands (endocannabinoids) and the enzymatic machinery for their synthesis and degradation. In the brain, endocannabinoids regulate ion channel activity and neurotransmitter release and thereby contribute to various aspects of brain function, including memory, reward and emotions. Their ability to modulate synaptic efficacy has a wide range of functional consequences and provides unique therapeutic possibilities. Unprecedented advances have been made in the understanding of the role of endocannabinoids in the regulation of the emotional brain over the past few years. However, a comprehensive book encompassing all these aspects is still lacking. The book will provide an overview of the role played by the endocannabinoid system in the regulation of emotional processes with particular emphasis on the modulation of memory and reward for emotionally arousing events and for the regulation of motivational aspects in cannabis use.
Comprehensive Toxicology
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 8639 |
| Release | : 2017-12-01 |
| Genre | : Science |
| ISBN | : 0081006128 |
Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts
From Bud to Brain: A Psychiatrist's View of Marijuana
| Author | : Timmen L. Cermak |
| Publisher | : Cambridge University Press |
| Total Pages | : 257 |
| Release | : 2020-04-02 |
| Genre | : Medical |
| ISBN | : 1108597572 |
The trend toward liberalizing medical and recreational marijuana use is increasing the obligation on clinicians to provide useful information to the public. This book summarizes the science all healthcare professionals need to know in order to provide objective and relevant information to a variety of patients, from recreational and medicinal users to those who use regularly, and to adolescents and worried parents. The author brings two and a half decades of studying cannabinoid research, and over forty years' experience in psychiatric and addiction medicine practice, to shed light on the interaction between marijuana and the brain. Topics range from how marijuana produces pleasurable sensations, relaxation and novelty (the 'high'), to emerging medical uses, effects of regular use, addiction, and policy. Principles of motivational interviewing are outlined to help clinicians engage patients in meaningful, non-judgmental conversations about their experiences with marijuana. An invaluable guide for physicians, nurses, psychologists, therapists, and counsellors.
Treatment of Posttraumatic Stress Disorder
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 224 |
| Release | : 2008-01-18 |
| Genre | : Medical |
| ISBN | : 0309109264 |
Mental disorders, including posttraumatic stress disorder (PTSD), constitute an important health care need of veterans, especially those recently separated from service. Treatment of Posttraumatic Stress Disorder: An Assessment of the Evidence takes a systematic look the efficacy of pharmacologic and psychological treatment modalities for PTSD on behalf of the Department of Veterans Affairs. By reviewing existing studies in order to draw conclusions about the strength of evidence on several types of treatment, the Committee on the Treatment of Posttraumatic Stress Disorder found that many of these studies were faulty in design and performance, and that relatively few of these studies have been conducted in populations of veterans, despite suggestions that civilian and veteran populations respond differently to various types of treatment. The committee also notes that the evidence is scarce on the acceptability, efficacy, or generalizability of treatment in ethnic and cultural minorities, as few studies stratified results by ethnic background. Despite challenges in the consistency, quality, and depth of research, the committee found the evidence sufficient to conclude the efficacy of exposure therapies in treating PTSD. The committee found the evidence inadequate to determine efficacy of different types of pharmacotherapies, of three different psychotherapy modalities, and of psychotherapy delivered in group formats. The committee also made eight critical recommendations, some in response to the VA's questions related to recovery and the length and timing of PTSD treatment, and others addressing research methodology, gaps in evidence and funding issues.
The American Psychiatric Publishing Textbook of Substance Abuse Treatment
| Author | : Marc Galanter |
| Publisher | : American Psychiatric Pub |
| Total Pages | : 982 |
| Release | : 2015-04-01 |
| Genre | : Medical |
| ISBN | : 1585625183 |
No other text available today offers what The American Psychiatric Publishing Textbook of Substance Abuse Treatment can: completely updated treatment information on a broad range of substance use disorders that is consistent with the new DSM-5 classification and thus reflective of how psychiatry is practiced today. Designed for researchers and mental health professionals ranging from trainee to licensed practitioner, the book is also appropriate for a diverse array of rehabilitation settings, from inpatient to community-based treatment. Full coverage is provided on 12-step programs, as well, including the latest outcomes research. Much of the material is new to this edition: A chapter has been added on science in the treatment of substance abuse, in which the authors discuss the history of scientific intervention in substance abuse and explore what happens to the brain when addicting drugs are consumed, review animal models and imaging techniques, and discuss current progress in the science of addiction. Chapters have been added on screening and brief intervention, reflecting the development of brief screening tools and research on the efficacy of interventions, and the role of "recovery" in chronic care disease management -- specifically what the treatment models for alcohol dependence and for diabetes can effectively borrow from each other. A new chapter focuses on the treatment of alcohol intoxication and withdrawal -- the first steps in treatment of alcohol use disorder. Two chapters on marijuana -- one on the neurobiology and one addressing treatment have been added. Given the accelerating trend toward decriminalization and legalization of this substance, clinicians will find this information of increasing importance. The section on substance use issues among gay men and lesbians has been expanded to include bisexual and transgender people in recognition of increased diversity among the population. Well-structured, with topics that follow logically and many practical, treatment-oriented features, such as quick reference tables and lists of recommended readings, The American Psychiatric Publishing Textbook of Substance Abuse Treatment is a classic that will enhance the education and practice of clinicians.
Behavioral Neurobiology of the Endocannabinoid System
| Author | : Dave Kendall |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 418 |
| Release | : 2009-08-14 |
| Genre | : Medical |
| ISBN | : 3540889558 |
The endocannabinoid signaling system is a key modulator of central nervous function. This volume, essential reading for interested neuroscientists, provides in-depth coverage of the roles of the endocannabinoid signaling system in the neurobiology of behavior.
Prolonged Exposure Therapy for PTSD
| Author | : Edna Foa |
| Publisher | : Oxford University Press |
| Total Pages | : 175 |
| Release | : 2007-03-22 |
| Genre | : Psychology |
| ISBN | : 019988580X |
An estimated 70% of adults in the United States have experienced a traumatic event at least once in their lives. Though most recover on their own, up to 20% develop chronic Posttraumatic Stress Disorder. For these people, overcoming PTSD requires the help of a professional. This guide gives clinicians the information they need to treat clients who exhibit the symptoms of PTSD. It is based on the principles of Prolonged Exposure Therapy, the most scientifically-tested and proven treatment that has been used to effectively treat victims of all types of trauma. Whether your client is a veteran of combat, a victim of a physical or sexual assault, or a casualty of a motor vehicle accident, the techniques and strategies outlined in this book will help. In this treatment clients are exposed to imagery of their traumatic memories, as well as real-life situations related to the traumatic event in a step-by-step, controllable way. Through these exposures, your client will learn to confront the trauma and begin to think differently about it, leading to a marked decrease in levels of anxiety and other PTSD symptoms. Clients are provided education about PTSD and other common reactions to traumatic events. Breathing retraining is taught as a method for helping the client manage anxiety in daily life. Designed to be used in conjunction with the corresponding client workbook, this therapist guide includes all the tools necessary to effectively implement the prolonged exposure program including assessment measures, session outlines, case studies, sample dialogues, and homework assignments. This comprehensive resource is an exceptional treatment manual that is sure to help you help your clients reclaim their lives from PTSD. TreatmentsThatWorkTM represents the gold standard of behavioral healthcare interventions! · All programs have been rigorously tested in clinical trials and are backed by years of research · A prestigious scientific advisory board, led by series Editor-In-Chief David H. Barlow, reviews and evaluates each intervention to ensure that it meets the highest standard of evidence so you can be confident that you are using the most effective treatment available to date · Our books are reliable and effective and make it easy for you to provide your clients with the best care available · Our corresponding workbooks contain psychoeducational information, forms and worksheets, and homework assignments to keep clients engaged and motivated · A companion website (www.oup.com/us/ttw) offers downloadable clinical tools and helpful resources · Continuing Education (CE) Credits are now available on select titles in collaboration with PsychoEducational Resources, Inc. (PER)
Cannabinoids as Therapeutics
| Author | : Raphael Mechoulam |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 278 |
| Release | : 2006-03-30 |
| Genre | : Medical |
| ISBN | : 376437358X |
Only a few years ago the endocannabinoid system was unknown. Today we are aware that endocannabinoids are involved in many of the functions of the mammalian body - in neuroprotection, appetite and suckling, pain, reproduction, anxiety, memory, bone formation etc. This volume presents an up-to-date picture of some of the major fields of endocannabinoid research. It summarizes the actions of the endocannabinoids on various physiological systems and opens new therapeutic windows to a large number of diseases. The first chapter, on the use of Cannabis in India, can be viewed as an expression of thanks to the herbal practitioners, who for centuries passed on the medical traditions associated with the drug. The chapter on chemistry is a short summary of active plant, synthetic and endogenous cannabinoids being investigated today, many of which are mentioned later in the book. Cannabidiol is an unusual cannabinoid - it does not bind to the known receptors and yet exerts a variety of effects. Hence a chapter is devoted to it. Further chapters deal with the endocannabinoid system and the endocannabinoids in a variety of conditions and physiological systems. The concluding chapter describes the research done on Sativex®, a standardized plant extract, shortly to be introduced in Canada as a drug for multiple sclerosis. The intended audience is drug researchers (medicinal chemists, pharmacologists, clinicians), neuroscientists, physiologists, and clinicians interested in the effect of the endocannabinoid system in various physiological systems.
Pain Management and the Opioid Epidemic
| Author | : National Academies of Sciences, Engineering, and Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 483 |
| Release | : 2017-09-28 |
| Genre | : Medical |
| ISBN | : 0309459575 |
Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
