The Encyclopedia Of Bioprocess Technology
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The Encyclopedia of Bioprocess Technology
Author | : Michael C. Flickinger |
Publisher | : Wiley-Interscience |
Total Pages | : 666 |
Release | : 1999 |
Genre | : Science |
ISBN | : |
Encyclopedia of Industrial Biotechnology
Author | : Michael C. Flickinger |
Publisher | : Wiley |
Total Pages | : 5051 |
Release | : 2010-03-22 |
Genre | : Science |
ISBN | : 9780470610053 |
Encyclopedia of Industrial Biotechnology
Author | : Michael C. Flickinger |
Publisher | : |
Total Pages | : |
Release | : 2010 |
Genre | : Biotechnology |
ISBN | : 9781615836604 |
Downstream Industrial Biotechnology
Author | : Michael C. Flickinger |
Publisher | : John Wiley & Sons |
Total Pages | : 884 |
Release | : 2013-07-17 |
Genre | : Science |
ISBN | : 111861898X |
DOWNSTREAM INDUSTRIAL BIOTECHNOLOGY An affordable, easily accessible desk reference on biomanufacturing, focused on downstream recovery and purification Advances in the fundamental knowledge surrounding biotechnology, novel materials, and advanced engineering approaches continue to be translated into bioprocesses that bring new products to market at a significantly faster pace than most other industries. Industrial scale biotechnology and new manufacturing methods are revolutionizing medicine, environmental monitoring and remediation, consumer products, food production, agriculture, and forestry, and continue to be a major area of research. The downstream stage in industrial biotechnology refers to recovery, isolation, and purification of the microbial products from cell debris, processing medium and contaminating biomolecules from the upstream process into a finished product such as biopharmaceuticals and vaccines. Downstream process design has the greatest impact on overall biomanufacturing cost because not only does the biochemistry of different products ( e.g., peptides, proteins, hormones, antibiotics, and complex antigens) dictate different methods for the isolation and purification of these products, but contaminating byproducts can also reduce overall process yield, and may have serious consequences on clinical safety and efficacy. Therefore downstream separation scientists and engineers are continually seeking to eliminate, or combine, unit operations to minimize the number of process steps in order to maximize product recovery at a specified concentration and purity. Based on Wiley’s Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, this volume features fifty articles that provide information on down- stream recovery of cells and protein capture; process development and facility design; equipment; PAT in downstream processes; downstream cGMP operations; and regulatory compliance. It covers: Cell wall disruption and lysis Cell recovery by centrifugation and filtration Large-scale protein chromatography Scale down of biopharmaceutical purification operations Lipopolysaccharide removal Porous media in biotechnology Equipment used in industrial protein purification Affinity chromatography Antibody purification, monoclonal and polyclonal Protein aggregation, precipitation and crystallization Freeze-drying of biopharmaceuticals Biopharmaceutical facility design and validation Pharmaceutical bioburden testing Regulatory requirements Ideal for graduate and advanced undergraduate courses on biomanufacturing, biochemical engineering, biopharmaceutical facility design, biochemistry, industrial microbiology, gene expression technology, and cell culture technology, Downstream Industrial Biotechnology is also a highly recommended resource for industry professionals and libraries.
Encyclopedia of Bioprocess Technology
Author | : Michael C. Flickinger |
Publisher | : Wiley-Interscience |
Total Pages | : 664 |
Release | : 1999 |
Genre | : Science |
ISBN | : |
The five-volume set of the Encyclopedia of Bioprocess Technology presents the applications and established theories in biotechnology-focusing on industrial applications of fermentation, biocatalysis and bioseparation. It is an essential resource for anyone working in industrial biotechnology, biochemistry, genetics and microbiology laboratories, pharmaceutical firms, regulatory agencies and chemical and environmental engineering companies.
Chemical Engineering and Chemical Process Technology - Volume V
Author | : Ryzhard Pohorecki |
Publisher | : EOLSS Publications |
Total Pages | : 338 |
Release | : 2010-11-30 |
Genre | : |
ISBN | : 1848264003 |
Chemical Engineering and Chemical Process Technology is a theme component of Encyclopedia of Chemical Sciences, Engineering and Technology Resources in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty Encyclopedias. Chemical engineering is a branch of engineering, dealing with processes in which materials undergo changes in their physical or chemical state. These changes may concern size, energy content, composition and/or other application properties. Chemical engineering deals with many processes belonging to chemical industry or related industries (petrochemical, metallurgical, food, pharmaceutical, fine chemicals, coatings and colors, renewable raw materials, biotechnological, etc.), and finds application in manufacturing of such products as acids, alkalis, salts, fuels, fertilizers, crop protection agents, ceramics, glass, paper, colors, dyestuffs, plastics, cosmetics, vitamins and many others. It also plays significant role in environmental protection, biotechnology, nanotechnology, energy production and sustainable economical development. The Theme on Chemical Engineering and Chemical Process Technology deals, in five volumes and covers several topics such as: Fundamentals of Chemical Engineering; Unit Operations – Fluids; Unit Operations – Solids; Chemical Reaction Engineering; Process Development, Modeling, Optimization and Control; Process Management; The Future of Chemical Engineering; Chemical Engineering Education; Main Products, which are then expanded into multiple subtopics, each as a chapter. These five volumes are aimed at the following five major target audiences: University and College students Educators, Professional practitioners, Research personnel and Policy analysts, managers, and decision makers and NGOs.
Solid-state Fermentation in Biotechnology
Author | : Ashok Pandey |
Publisher | : |
Total Pages | : 240 |
Release | : 2001 |
Genre | : Solid-state fermentation |
ISBN | : |
This book complements others in biotechnology especially in industrialmicrobiology-biotechnology. It has been written with a research andacademic readership in mind but will prove equally beneficial to theprocess technologists and scientists working in biotechnology-basedbusiness and industries, large and small. The chapters include theinformation and facts based on the practically applicable knowledgegathered from up-to-date complete research published on the subjectand related topics. The contents of each chapter deal with How-to , asopposed to a Review of Literature with citation of a large number ofnon-applicable references .
Bioprocess Engineering Principles
Author | : Pauline M. Doran |
Publisher | : Elsevier |
Total Pages | : 455 |
Release | : 1995-04-03 |
Genre | : Science |
ISBN | : 0080528120 |
The emergence and refinement of techniques in molecular biology has changed our perceptions of medicine, agriculture and environmental management. Scientific breakthroughs in gene expression, protein engineering and cell fusion are being translated by a strengthening biotechnology industry into revolutionary new products and services. Many a student has been enticed by the promise of biotechnology and the excitement of being near the cutting edge of scientific advancement. However, graduates trained in molecular biology and cell manipulation soon realise that these techniques are only part of the picture. Reaping the full benefits of biotechnology requires manufacturing capability involving the large-scale processing of biological material. Increasingly, biotechnologists are being employed by companies to work in co-operation with chemical engineers to achieve pragmatic commercial goals. For many years aspects of biochemistry and molecular genetics have been included in chemical engineering curricula, yet there has been little attempt until recently to teach aspects of engineering applicable to process design to biotechnologists.This textbook is the first to present the principles of bioprocess engineering in a way that is accessible to biological scientists. Other texts on bioprocess engineering currently available assume that the reader already has engineering training. On the other hand, chemical engineering textbooks do not consider examples from bioprocessing, and are written almost exclusively with the petroleum and chemical industries in mind. This publication explains process analysis from an engineering point of view, but refers exclusively to the treatment of biological systems. Over 170 problems and worked examples encompass a wide range of applications, including recombinant cells, plant and animal cell cultures, immobilised catalysts as well as traditional fermentation systems.* * First book to present the principles of bioprocess engineering in a way that is accessible to biological scientists* Explains process analysis from an engineering point of view, but uses worked examples relating to biological systems* Comprehensive, single-authored* 170 problems and worked examples encompass a wide range of applications, involving recombinant plant and animal cell cultures, immobilized catalysts, and traditional fermentation systems* 13 chapters, organized according to engineering sub-disciplines, are groupled in four sections - Introduction, Material and Energy Balances, Physical Processes, and Reactions and Reactors* Each chapter includes a set of problems and exercises for the student, key references, and a list of suggestions for further reading* Includes useful appendices, detailing conversion factors, physical and chemical property data, steam tables, mathematical rules, and a list of symbols used* Suitable for course adoption - follows closely curricula used on most bioprocessing and process biotechnology courses at senior undergraduate and graduate levels.