The Elucidation
| Author | : Albert Wilder Thompson |
| Publisher | : Slatkine |
| Total Pages | : 138 |
| Release | : 1982 |
| Genre | : Grail |
| ISBN | : 9782051004138 |
The Elucidation
Download The Elucidation full books in PDF, epub, and Kindle. Read online free The Elucidation ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Analytical Techniques for the Elucidation of Protein Function
| Author | : Isao Suetake |
| Publisher | : John Wiley & Sons |
| Total Pages | : 245 |
| Release | : 2023-01-04 |
| Genre | : Science |
| ISBN | : 1119886341 |
ANALYTICAL TECHNIQUES FOR THE ELUCIDATION OF PROTEIN FUNCTION An essential aid for scientists seeking alternative techniques for investigating proteins Proteins are the building blocks of living organisms, and they play an enormous range of fundamental roles in sustaining and shaping life. The critical determinant of a protein’s function is its structure, and the analysis of protein structures has therefore become a significant component of biological research. In recent years, longstanding analytical techniques such as X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy have been supplemented by a number of new methods which promise to revolutionize the study of proteins and their functions. Analytical Techniques for the Elucidation of Protein Function serves as an introduction to these techniques, which are especially crucial for analyzing intrinsically disordered regions and post-translational modifications. These have revolutionized the study of proteins in recent years, and conventional methods for analyzing protein structures are no longer sufficient to work through their ramifications. This book therefore brings greater awareness of techniques which promise to produce the very cutting edge of protein research. Analytical Techniques for the Elucidation of Protein Function readers will find: A discussion of techniques including electron paramagnetic resonance (ESR) spectroscopy, neutron scattering, Raman imaging, and more Both theoretical background and practical applications for each technique Contributions from leading international researchers into protein structure and function This practically focused text is a valuable reference for protein and peptide analysis and synthesis researchers, as well as for graduate and advanced undergraduate students in the life sciences.
Maimonides, On the Elucidation of Some Symptoms and the Response to Them (Formerly Known as On the Causes of Symptoms)
| Author | : Gerrit Bos |
| Publisher | : BRILL |
| Total Pages | : 189 |
| Release | : 2019-05-15 |
| Genre | : Medical |
| ISBN | : 9004398805 |
The present consilium, commonly known as De causis accidentium, after the Latin translation by John de Capua, was, like the earlier consilium On the Regimen of Health, composed by Maimonides at the request of al-Malik al-Afḍal Nūr al-Dīn Alī, Saladin’s eldest son. As a result of not adopting the lifestyle and dietary recommendations in On the Regimen of Health, al-Afḍal may have continued to suffer from a number of afflictions, amongst them hemorrhoids, depression, constipation, and, possibly, a heart condition. The consilium was written after 1200, the year in which al-Afḍal was deposed and banished from Egypt permanently, but probably not long before 1204, the year in which Maimonides died.
Modern NMR Approaches to the Structure Elucidation of Natural Products
| Author | : Antony Williams |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 532 |
| Release | : 2016-12-14 |
| Genre | : Science |
| ISBN | : 1849733937 |
The Ghanian plant Cryptolepis sanguinolenta is the source of a series of fascinating indoloquinoline alkaloids. The most unusual member of this alkaloid series was initially proposed to be a spiro nonacyclic structure, named cryptospirolepine, and was elucidated in 1993 based on the technologies available at that time. There were, however, several annoying attributes to the structure that bothered analysts for the ensuing 22 years. During the two decades that followed the initial work there have been enormous developments in NMR technology. Using new experimental approaches, specifically homodecoupled 1,1- and 1,n-HD-ADEQUATE NMR experiments developed in 2014, the structure of only a 700 µg sample of cryptospirolepine has been revised and is shown on the cover of this volume. The confluence of the NMR technological and methodological advances that allowed the revision of the structure of cryptospirolepine using a submilligram sample seems a fitting example for this book, which is dedicated to the NMR characterization of various classes of natural products. Volume 2 considers data processing and algorithmic based analyses tailored to natural product structure elucidation and reviews the application of NMR to the analysis of a series of different natural product families including marine natural products, terpenes, steroids, alkaloids and carbohydrates. Volume 1 discusses contemporary NMR approaches including optimized and future hardware and experimental approaches to obtain both the highest quality and most appropriate spectral data for analysis. These books, bringing together acknowledged experts, uniquely focus on the combination of experimental approaches and modern hardware and software applied to the structure elucidation of natural products. The volumes will be an essential resource for NMR spectroscopists, natural product chemists and industrial researchers working on natural product analysis or the characterization of impurities and degradation products of pharmaceuticals that can be as scarce as natural product samples.
Computer–Based Structure Elucidation from Spectral Data
| Author | : Mikhail E. Elyashberg |
| Publisher | : Springer |
| Total Pages | : 458 |
| Release | : 2015-02-27 |
| Genre | : Science |
| ISBN | : 3662464020 |
Here, the authors introduce readers to solving molecular structure elucidation problems using the expert system ACD/Structure Elucidator. They explain in detail the concepts of the Computer-Assisted Structure Elucidation (CASE) approach and point out the crucial role of understanding the axiomatic nature of the data used to deduce the structure. Aspects covered include the main blocks of the expert system and essential features of the mathematical algorithms used. Graduate and PhD students as well as practicing chemists are provided with a detailed explanation of the various practical approaches depending on available spectral data peculiarities and the complexity of the unknown structure. This is supported by a large number of real-world completed examples, most of which are related to the structure elucidation of natural product molecules containing unusual skeletons. Dedicated software and further supplementary material are available at www.acdlabs.com/TeachingSE.
Contemporary Computer-Assisted Approaches to Molecular Structure Elucidation
| Author | : Mikhail E Elyashberg |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 505 |
| Release | : 2011-11-07 |
| Genre | : Science |
| ISBN | : 1849734577 |
Computer-Assisted Structure Elucidation (CASE) systems are a combination of software algorithms and tools to support and enable chemists and spectroscopists engaged in the process of molecular structure elucidation via the analysis of spectroscopic data. These expert systems dramatically reduce the time associated with structure elucidation and improve the reliability of the results. Contemporary Computer-Assisted Approaches to Molecular Structure Elucidation describes the principles on which these expert systems for spectroscopic structure elucidation are based and concisely explains the algorithmic concepts behind the programs. The authors use their own personal experiences in the development of the Structure Elucidator (StrucEluc) CASE software system to discuss the present state-of-the-art in computer-assisted structure elucidation. Scientists that are presently using CASE systems will be interested in the algorithms and modern approaches and for organizations that are currently using the StrucEluc platform the book is designed to help researchers understand the strategies behind CASE as well as details regarding the StrucEluc platform. For scientists that have never used CASE systems they will now have access to all necessary information to understand CASE systems for mastering this new and very effective approach to structure elucidation. The authors overall goal is writing this book is to produce the 'must read' definitive text that will represent the results of decades of work to develop computer-assisted structure elucidation software systems. CASE systems are now powerful software tools commonly outperforming and correcting human interpretations of data. This book will also provide an historical perspective of the work of the founding fathers of the technique and identify the challenges that have been overcome to produce modern CASE systems.
The discovery of bioactive natural products: The isolation and structural elucidation, genome mining, OSMAC strategy, and biotransformation
| Author | : Ling Liu |
| Publisher | : Frontiers Media SA |
| Total Pages | : 161 |
| Release | : 2023-08-30 |
| Genre | : Science |
| ISBN | : 2832532756 |
Structure Elucidation in Organic Chemistry
| Author | : Maria-Magdalena Cid |
| Publisher | : John Wiley & Sons |
| Total Pages | : 552 |
| Release | : 2014-12-17 |
| Genre | : Science |
| ISBN | : 3527664645 |
Intended for advanced readers, this is a review of all relevant techniques for structure analysis in one handy volume. As such, it provides the latest knowledge on spectroscopic and related techniques for chemical structure analysis, such as NMR, optical spectroscopy, mass spectrometry and X-ray crystallography, including the scope and limitation of each method. As a result, readers not only become acquainted with the techniques, but also the advantages of the synergy between them. This enables them to choose the correct analytical method for each problem, saving both time and resources. Special emphasis is placed on NMR and its application to absolute configuration determination and the analysis of molecular interactions. Adopting a practical point of view, the author team from academia and industry guarantees both solid methodology and applications essential for structure determination, equipping experts as well as newcomers with the tools to solve any structural problem.
Classical Methods in Structure Elucidation of Natural Products
| Author | : Reinhard W. Hoffmann |
| Publisher | : John Wiley & Sons |
| Total Pages | : 274 |
| Release | : 2017-12-27 |
| Genre | : Science |
| ISBN | : 3906390780 |
The structures of many natural products are given in standard textbooks on organic chemistry as 'established facts'. Yet for those natural products whose structures were determined between 1860 and 1960 by classical chemical methods, the lines of evidence are frequently buried under any number of investigations that led to dead ends and to revised structure assignments. Since very little is known about the structure clarification of these products at present, this volume serves to shed light once again on the achievements of previous generations of chemists, who worked with minimal experimental tools. The selection of the 25 representative examples is subjective and arbitrary, dictated by the author's pleasure in recovering fundamental milestones in organic chemistry, with each chapter devoted to one organic compound. The time period covered, however, is more precisely defined: 1860 represents the advent of structure theory, prior to which there was no conceptual framework to address the 'structure' of a compound. One hundred years later, 1960 approximately marks the change from classical structure elucidation to the era in which structure elucidation is mainly based on spectroscopic evidence and X-ray crystallography. Since the emphasis of this work is on classical structure elucidation, work performed later than 1960 is only considered in exceptional cases. Rather than simply provide a history of structure elucidation of particular natural products, the author combines results from historic experiments to trace a line of evidence for those structures that are nowadays accepted as established. This line of evidence may follow the path put forward by the original contributors, yet in some cases the experimental facts have been combined to form another, hopefully shorter, line of evidence. As a result, readers are able to ascertain for themselves the 'facts behind the established structure assignments' of a number of important natural products.
