This book explores the cultural exchange between Italy and Spain in the seventeenth century, examining Spanish collectors’ predilection for Italian painting and its influence on Spanish painters. Focused on collecting and using a novel methodology, this volume studies how the painters of the Sevillian school, including Francisco Pacheco, Diego Velázquez, Alonso Cano and Bartolomé Esteban Murillo, perceived and were influenced by Italian painting. Through many examples, it is shown how the presence in Andalusia of various works and copies of works by artists such as Michelangelo, Caravaggio and Guido Reni inspired famous compositions by these Spanish artists. In addition, the book delves into the historical, political and social context of this period. The book will be of interest to scholars working in art history, Renaissance studies, and Italian and Spanish history.