Here is a fascinating reader-friendly exploration of “the phosphorus enigma.” The volume attempts to answer the questions: How did phosphorus atoms, which are produced inside the inner cores of a handful of huge stars, become concentrated in relatively high proportions in the organisms composing Earth’s biosphere? And how did these phosphate derivatives manage to be included in such a great variety of organic molecules playing essential biochemical roles in all known life forms? Due to the interdisciplinary nature of the topic, the volume is arranged in three sections. The first section introduces the fundamental concepts and notions of physics, chemistry, and biology necessary for the proper understanding of the topics discussed within an astronomical framework. The author then focuses on the role of phosphorus and its compounds within the context of chemical evolution in galaxies, considering its relevance in most essential biochemical functions as well as its peculiar chemistry under different physicochemical conditions. The third section provides an overall perspective on the role of phosphorus and its compounds in current areas of research of solid state physics, materials engineering, nanotechnology or medicine.