The Characterization Of A Human Nitric Oxide Synthase I Promoter Complex
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| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 375 |
| Release | : 1996-09-18 |
| Genre | : Science |
| ISBN | : 0080536379 |
Although the function of nitric oxide in a regulatory capacity in the central and peripheral nervous system is widely recognized, the full scope of its actions and its interrelationships with other classes of regulatory molecules is just beginning to be comprehended. This volume contains a number of sophisticated and advanced methods essential for exploring the activity of nitric oxide in the brain. It will be a valuable tool for the established investigator and for those just entering the field. - Comprehensive protocols included for detection of NO and related compounds by chemical, immunohistochemical, and in situ hybridization techniques - Newly developed methods for the purification of neuronal and endothelial NO synthase, production of monoclonal antibodies to NO synthase, molecular cloning and expression of NO synthesis, and control of NO synthase gene expression - Assessment of NO-mediated functions in neurons, central nervous system, cerebral circulation, synaptic transmission, and vascular tone - Calcium imaging by confocal microscopy, evaluation of the effect of NO on iron metabolism, and detection of heme oxygenase-1 and -2 message level and distribution
| Author | : Seyed Soheil Saeedi Saravi |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 250 |
| Release | : 2017-05-17 |
| Genre | : Science |
| ISBN | : 953513163X |
Nitric Oxide Synthase - Simple Enzyme-Complex Roles provides information on nitric oxide synthase, a biomolecule of key importance for the different biological systems, including central and peripheral nervous, cardiovascular, and reproductive systems. With recent links to the role of nitric oxide in the reactions that can impact cell signaling, and discoveries surrounding the complex role of nitric oxide synthase that have increased research attention across the fields of cell and molecular biology, physiology, pharmacology, toxicology, neuroscience, cardiology, urology, and endocrinology, this book tries to provide a comprehensive overview of biology/pathobiology of nitric oxide synthases and a perspective from possible therapeutic indication of the enzyme inhibitors.
| Author | : |
| Publisher | : |
| Total Pages | : 1860 |
| Release | : 1999 |
| Genre | : Medicine |
| ISBN | : |
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 333 |
| Release | : 1995-04-07 |
| Genre | : Medical |
| ISBN | : 0080537553 |
The gas nitric oxide (NO) has burst upon neuroscience only recently, and yet it has permeated into almost every avenue of current research. The unique properties of this novel messenger have revolutionized our way ofthinking about neurotransmission. These special properties have also lead neuroscientists to invoke NO to explain many previously unexplained phenomena in neurobiology. Fortunately, the development of numerous pharmacological agents is now allowing thesehypotheses to be tested.This volume will provide a synopsis of what is now known about NO. How and where NO is produced, how it acts at the molecular level to activate the synthesis of cGMP, and the possible targets of cGMP in the nervous system are reviewed. The roles of theNO/cGMP signal transduction pathway in the central and peripheral nervous systems, in glial cells, and in neuropathology are then explored. Together, these reviews will lead to further work explaining the varied functions of NO.Key Features* Describes how and why NO is produced in the nervous system* Examines all that is known of NOs role as a neurotransmitter* Explores cellular actions and physiological roles in the brain and peripheral nervous systemCovers NOs molecular synthesis to its role in neuropathology
| Author | : |
| Publisher | : |
| Total Pages | : 882 |
| Release | : 2004 |
| Genre | : Dissertations, Academic |
| ISBN | : |
| Author | : Michel Félétou |
| Publisher | : Morgan & Claypool Publishers |
| Total Pages | : 309 |
| Release | : 2011 |
| Genre | : Science |
| ISBN | : 1615041230 |
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
| Author | : Ernst van Faassen |
| Publisher | : Elsevier |
| Total Pages | : 444 |
| Release | : 2011-10-13 |
| Genre | : Science |
| ISBN | : 0080489591 |
Radicals for Life: the Various Forms of Nitric Oxide provides an up-to-date overview of the role of nitrosocompounds and nitrosyl-iron complexes in physiology. Nitrosocompounds can be considered as stabilised forms of nitric oxide, one of the most important regulatory molecules in physiology today. Many nitrosocompounds share some of the physiological functions of nitric oxide, and may be formed inside living organisms. This is the first book to be published that is dedicated to the role of such nitrosocompounds in physiology, with particular emphasis on the nitrosocompounds that are endogenously formed in higher organisms and humans. Points of discussion include: physical and chemical properties of the compounds, the main chemical pathways in vivo, as well as the physiological effects that have been recognised to date. Each of the nineteen chapters is written by distinguished specialists in the field, well known for their original and important contributions to the subject. Also included are results from a wide range of studies in vitro, in cell cultures, animal models and human volunteers. Examples of alternative forms of nitric oxide, with special emphasis on their protective role against widespread human diseases like atherosclerosis, Alzheimer's disease, diabetes, sexual dysfunction, and renal insufficiency to stroke and ischemia are also included. - First monograph to consider and provide an overview of endogenous nitrosocompounds and nitrosyl-iron complexes - Extensive bibliographic references, written by specialists of human physiology - Providing high scientific quality with a focus on implications for human diseases
| Author | : |
| Publisher | : |
| Total Pages | : 776 |
| Release | : 2002 |
| Genre | : Dissertation abstracts |
| ISBN | : |
| Author | : |
| Publisher | : |
| Total Pages | : 2068 |
| Release | : 2004 |
| Genre | : Medicine |
| ISBN | : |
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
| Author | : Rui Wang |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 372 |
| Release | : 2004-06-11 |
| Genre | : Medical |
| ISBN | : 1592598064 |
Gasotransmitters-principally nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)-are endogenous signaling molecules that play a significant role in the biomedical, clinical, and health sciences, as well as in population health studies. In Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine, a panel of distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing their signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels. Included in the array of different mechanisms for the interaction of NO, CO, and H2S are channel phosphorylation, S-nitrosylation, carboxylation, sulfuration, and altered cellular redox status. The authors also offer guidance and suggestions for exploring and further characterizing other still unknown gasotransmitters. Authoritative and comprehensive, Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine offers clinical scientists and physicians not only a deeper understanding, but also a cutting-edge review, of the critically important field of gasotransmitter biology and medicine.
