The Benzodiazepine Receptor
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| Author | : Josee Savard |
| Publisher | : Academic Press |
| Total Pages | : 475 |
| Release | : 2019-03-14 |
| Genre | : Psychology |
| ISBN | : 0128130156 |
Handbook of Sleep Disorders in Medical Conditions reviews the current knowledge on the nature and manifestations of sleep disorders associated with a variety of common medical conditions, including epilepsy, traumatic brain injury and dementia. It also provides clinical guidelines on how to assess and treat them with pharmacological and non-pharmacological interventions. Although the general principles of sleep medicine may be applied to some extent to patients with comorbid medical conditions, this book makes the case that an adaptive approach is warranted when considering the particularities of each condition. In addition, clinicians must also be cautious when prescribing sleep medications as some pharmacological agents are known to exacerbate symptoms associated with the medical condition, such as cognitive deficits (i.e. difficulties with memory and attention) in cancer patients experiencing chemo brain, or in persons with neurologic conditions (e.g. mild cognitive impairment, dementia, stroke, brain injury). A differential approach to evaluating and treating sleep is thus warranted. - 2020 PROSE Awards - Winner: Category: Textbook/Medicine and Clinical Science: Association of American Publishers - Presents a general overview on assessing and treating sleep disorders that are applicable to a diverse set of patients - Provides a comprehensive, up-to-date review of the literature on the prevalence and manifestations of sleep problems related to specific medical conditions - Includes practical information regarding special considerations for the assessment and treatment of sleep issues in specific medical conditions - 2020 PROSE Award Subject Winner in Textbook/Medicine and Clinical Science (Association of American Publishers)
| Author | : Adam C. Errington |
| Publisher | : Springer |
| Total Pages | : 301 |
| Release | : 2014-09-22 |
| Genre | : Medical |
| ISBN | : 149391426X |
GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.
| Author | : John Peppin |
| Publisher | : Oxford University Press |
| Total Pages | : 289 |
| Release | : 2020-10-01 |
| Genre | : Psychology |
| ISBN | : 0197517293 |
Developed decades ago to treat a legitimate medical need, benzodiazepines promisingly displaced less-effective and less-safe drugs, though prescribing has since exceeded their intended use and outpaced the available data. The current situation is characterized by excessive prescribing and extended utilization beyond good therapeutic practice. Evidence indicates that prolonged use of benzodiazepines causes a wide range of adverse reactions, and withdrawal can be particularly challenging. Misused, abused, diverted, and counterfeited, benzodiazepines have serious potential for substance use disorder, and are among the leading causes of drug-related overdose deaths. The Benzodiazepines Crisis sounds the alarm against the overuse of benzodiazepines, presenting an updated, evidence-based overview of this class of drugs and their negative consequences. Bringing together years of research, clinical expertise, and scientific evidence, this book aims to address a perceived lag between evidence and action in order to call for rational and dramatically reduced usage of benzodiazepines.
| Author | : Jürgen Schüttler |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 497 |
| Release | : 2008-01-08 |
| Genre | : Medical |
| ISBN | : 3540748067 |
Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. These constraints were already recognised 35 years ago, when in 1972 Volume XXX entitled “Modern Inhalation Anesthetics” appeared in this Handbook Series. The present volume is meant as a follow up and extension of that volume. At the beginning of the 1970’s anesthesia was commonly delivered by inhalation, with only very few exceptions. The clinical understanding of that time considered anesthesia as a unique state achieved by any of the inhalation anesthetics, in- pendent of their specific molecular structure. “The very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”.
| Author | : Martin Sarter |
| Publisher | : Wiley-Liss |
| Total Pages | : 328 |
| Release | : 1995-01-23 |
| Genre | : Medical |
| ISBN | : |
Provides a comprehensive overview of the biochemical, pharmacological and behavioral research on benzodiazepine receptor (BZR) inverse agonists. Emphasis is given to psychopharmacological potential (including cognitive and motivational enhancement) andtreatment applications (ethanol-antagonism, movement disorders, head injury). The book contains black-and-white illustrations.
| Author | : Richard W. Olsen |
| Publisher | : |
| Total Pages | : 376 |
| Release | : 1986 |
| Genre | : Medical |
| ISBN | : |
The fifth volume in the series is the first to deal exclusively with a single type of receptor. Contributions represent the most up-to-date research in the benzodiazepine/GABA receptor-chloride channel complex, an extremely interesting protein of great neurobiological significance. Major workers in the field describe the history of GABA receptors and the benzodiazepine connection''. Lays out background material in a particularly clear fashion to allow readers from outside the field to quickly grasp the main points. Presents in detail the allosteric interactions between the various components of the benzodiazepine/GABA receptor complex from the points of view of several authors, so that readers can choose their level of involvement with these details. Includes the most recent advances on the biochemical purification, characterization, and development of monoclonal antibodies for the benzodiazepine/GABA receptor protein.
| Author | : Ivan Izquierdo |
| Publisher | : CRC Press |
| Total Pages | : 146 |
| Release | : 1993-01-01 |
| Genre | : Medical |
| ISBN | : 9780130154880 |
An exploration of benzodiazepines (BZDs), including the widely-used drug Valium, which have been in wide circulation in clinical practice since the 1960s as sedatives, antidepressants, hypnotics and anticonvulsants. It reveals research results with naturally-occurring BZDs in plants and animals.
| Author | : David Nutt |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 102 |
| Release | : 2013-09-26 |
| Genre | : Medical |
| ISBN | : 0199685703 |
An essential reference for psychiatrists, clinical psychologists, trainees, and specialist nurses, as well as primary care physicians/GPs with a special interest in mental health conditions and other healthcare professionals.
| Author | : Malcolm Lader |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 319 |
| Release | : 2009-11-06 |
| Genre | : Medical |
| ISBN | : 0387276823 |
Many recent discoveries in both laboratory and clinical settings have greatly increased our understanding of sleep medicine and the relevant psychopharmacology. This timely book serves to present updated information about the neuropsychopharmacology of sleep as this field enters mainstream psychiatry, neurology and medicine This volume has assembled articles that summarize and review carefully, a chosen selection of the latest discoveries concerning sleep medicine, sleep physiology and sleep pharmacology. Outstanding contributions have been sought from acknowledged experts in their respective fields. The goal of the volume is to present the more recent developments and advances in the fields of sleep and neuropsychopharmacology, as well as to provide a context for considering them both in depth and from multidisciplinary perspectives. This volume brings together the collective expertise of clinicians and basic researchers who represent a range of interests in neuroscience, neuropharmacology, sleep physiology, and biological rhythms. Presenting a thoughtful balance of basic experimental and clinical facts and viewpoints, this book will serve as a foundation for understanding, and ultimately treating, sleep disorders.
| Author | : M. Endo |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 674 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 3642570836 |
Cells maintain uneven distribution of Na, K and Ca ions across the cell membrane and membranes of intracellular organellae. Cells exert their functions by allowing for some ion to cross the membrane through ion channels which either produces an electrical effect across the membrane or switches on a series of chemical or physicochemical reactions. This is a comprehensive book about these vitally important ion channels with detailed description of the molecular structure and function and especially of activators and inhibitors. All chapters are written by renowned specialists in their field.
