Textbook Of Medicinal Chemistry
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| Author | : V Alagarsamy |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 833 |
| Release | : 2012-06-16 |
| Genre | : Medical |
| ISBN | : 813123259X |
Dr Alagarsamy's Textbook of Medicinal Chemistry is a much-awaited masterpiece in its arena. Targeted mainly to B. Pharm. students, this book will also be useful for M. Pharm. as well as M. Sc. organic chemistry and pharmaceutical chemistry students. It aims at eliminating the inadequacies in teaching and learning of medicinal chemistry by providing enormous information on all the topics in medicinal chemistry of synthetic drugs. Salient Features Contains clear classification, synthetic schemes, mode of action, metabolism, assay, pharmacological uses with the dose and structure–activity relationship (SAR) of the following classes of drugs: Drugs acting on inflammation Drugs acting on respiratory system Drugs acting on digestive system Drugs acting on blood and blood-forming organs Drugs acting on endocrine system Contains a complete section on chemotherapy and the various classes of chemotherapeutic agents. Also includes recent topics like anti-HIV agents Contains brief introduction about the physiological and pathophysiological conditions of diseases and their treatment under each topic Provides well-illustrated synthetic schemes and alternative synthetic routes for majority of drugs that help in quick and enhanced understanding of the subject Covers the syllabi of majority of Indian universities
| Author | : V Alagarsamy |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 1010 |
| Release | : 2013-06-17 |
| Genre | : Medical |
| ISBN | : 8131232581 |
Dr Alagarsamy's Textbook of Medicinal Chemistry is a much-awaited masterpiece in its arena. Targeted mainly to B. Pharm. students, this book will also be useful for M. Pharm. as well as M. Sc. organic chemistry and pharmaceutical chemistry students. It aims at eliminating the inadequacies in teaching and learning of medicinal chemistry by providing enormous information on all the topics in medicinal chemistry of synthetic drugs. Salient Features Contains clear classification, synthetic schemes, mode of action, metabolism, assay, pharmacological uses with the dose and structure–activity relationship (SAR) of the following classes of drugs: Drugs acting on inflammation Drugs acting on respiratory system Drugs acting on digestive system Drugs acting on blood and blood-forming organs Drugs acting on endocrine system Contains a complete section on chemotherapy and the various classes of chemotherapeutic agents. Also includes recent topics like anti-HIV agents Contains brief introduction about the physiological and pathophysiological conditions of diseases and their treatment under each topic Provides well-illustrated synthetic schemes and alternative synthetic routes for majority of drugs that help in quick and enhanced understanding of the subject Covers the syllabi of majority of Indian universities
| Author | : Algar |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 622 |
| Release | : 2010 |
| Genre | : |
| ISBN | : 813122189X |
The Textbook of Medicinal Chemistry is a much-awaited masterpiece in its arena. Targeted mainly to B. Pharmacy students, book would also be useful for M. Pharmacy as well as M.Sc. Organic Chemistry/Pharmaceutical Chemistry students. It aims at eliminating the inadequacies in teaching and learning of medicinal chemistry by providing enormous information on all the topics in medicinal chemistry of synthetic drugs. About the Author : - Prof. Dr. V. Alagarsamy, M. Pharm., Ph.D., FIC., D.O.M.H., is Professor and Principal of MNR College of Pharmacy, Gr. Hyderabad, Sangareddy. He has been teaching Medicinal Chemistry and performing research work in Synthetic Medicinal Chemistry on novel heterocyclic bioactive compounds for more than a decade. His research activities are collaborated with various research laboratories/organisations like National Cancer Institute, USA; Rega Institute for Medical Research, Belgium and Southern Research Institute, USA. He is a recipient of Young Scientist award from the Department of Science and Technology, New Delhi. His research publications in journals and presentations in conferences, put together, exceed hundred. His research activities are supported by the funding agencies like CSIR, DST and DSIR. He is a doctoral committee member and recognized Research guide for Ph.D. students in various universities.
| Author | : Marc Harrold |
| Publisher | : ASHP |
| Total Pages | : 405 |
| Release | : 2013-01-18 |
| Genre | : Medical |
| ISBN | : 1585283649 |
Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group. Key features include: • Discussions on the roles and characteristics of organic functional groups, including the identification of acidic and basic functional groups. • How to solve problems involving pH, pKa, and ionization; salts and solubility; drug binding interactions; stereochemistry; and drug metabolism. • Numerous examples and expanded discussions for complex concepts. • Therapeutic examples that link the importance of medicinal chemistry to pharmacy and healthcare practice. • An overview of structure activity relationships (SARs) and concepts that govern drug design. • Review questions and practice problems at the end of each chapter that allow readers to test their understanding, with the answers provided in an appendix. Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry. About the Authors Marc W. Harrold, BS, Pharm, PhD, is Professor of Medicinal Chemistry at the Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA. Professor Harrold is the 2011 winner of the Omicron Delta Kappa "Teacher of the Year" award at Duquesne University. He is also the two-time winner of the "TOPS" (Teacher of the Pharmacy School) award at the Mylan School of Pharmacy. Robin M. Zavod, PhD, is Associate Professor for Pharmaceutical Sciences at the Chicago College of Pharmacy, Midwestern University, Downers Grove, IL, where she was awarded the 2012 Outstanding Faculty of the Year award. Professor Zavod also serves on the adjunct faculty for Elmhurst College and the Illinois Institute of Technology. She currently serves as Editor-in-Chief of the journal Currents in Pharmacy Teaching and Learning.
| Author | : Charles Owens Wilson |
| Publisher | : Lippincott Williams & Wilkins |
| Total Pages | : 1150 |
| Release | : 1977 |
| Genre | : Medical |
| ISBN | : |
| Author | : Camille Georges Wermuth |
| Publisher | : Elsevier |
| Total Pages | : 903 |
| Release | : 2015-07-01 |
| Genre | : Science |
| ISBN | : 012417213X |
The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com
| Author | : Thomas Nogrady |
| Publisher | : Oxford University Press |
| Total Pages | : 664 |
| Release | : 2005-08-11 |
| Genre | : Medical |
| ISBN | : 0190282967 |
Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.
| Author | : Graham L. Patrick |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 814 |
| Release | : 2013-01-10 |
| Genre | : Medical |
| ISBN | : 0199697396 |
This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.
| Author | : V. ALAGARSAMY |
| Publisher | : CBS Publishers & Distributors Pvt Limited, India |
| Total Pages | : |
| Release | : 2018-03-30 |
| Genre | : Medical |
| ISBN | : 9789385915505 |
This popular textbook for pharmacy students provides all the information they need to know about medicinal chemistry. The third edition features new layout and design in an attractive two-colour presentation. It contains clear classifications, synthetic schemes, modes of action, metabolism, assay, pharmacological uses with the dose and structure activity relationship (SAR) of the drugs for the various body systems. - Contains a complete section on drug design, describing the new drug development. - Includes an introduction to the physiological and pathophysiological conditions of diseases and their treatment. - Provides well-illustrated synthetic schemes and alternative synthetic routes for the majority of drugs. - Additional physico-chemical parameters have been explained.
| Author | : Andrejus Korolkovas |
| Publisher | : Wiley-Interscience |
| Total Pages | : 1220 |
| Release | : 1988-08-16 |
| Genre | : Medical |
| ISBN | : |
This text/reference presents fundamental aspects of medicinal chemistry and contains comprehensive information on approximately 5,000 drugs currently in use, describing their therapeutic uses, their mechanisms of action, and their main side and harmful effects. Employs the latest World Health Organization (WHO) pharmacological classification and provides extensive information for drugs on WHO's latest list of basic or essential pharmaceuticals, including history: chemical, trade and generic names; chemical structure; obtention; physical and chemical properties; mechanisms of action; therapeutic uses; adverse reactions; biotransformation; chemical and pharmacological incompatibilities; bioavailability; dosage; storage; and assay.
