Targeted Molecular Imaging Of Brain Cancer
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Author | : Elke Hattingen |
Publisher | : Springer |
Total Pages | : 166 |
Release | : 2015-09-02 |
Genre | : Medical |
ISBN | : 3642450407 |
This book describes the basics, the challenges and the limitations of state of the art brain tumor imaging and examines in detail its impact on diagnosis and treatment monitoring. It opens with an introduction to the clinically relevant physical principles of brain imaging. Since MR methodology plays a crucial role in brain imaging, the fundamental aspects of MR spectroscopy, MR perfusion and diffusion-weighted MR methods are described, focusing on the specific demands of brain tumor imaging. The potential and the limits of new imaging methodology are carefully addressed and compared to conventional MR imaging. In the main part of the book, the most important imaging criteria for the differential diagnosis of solid and necrotic brain tumors are delineated and illustrated in examples. A closing section is devoted to the use of MR methods for the monitoring of brain tumor therapy. The book is intended for radiologists, neurologists, neurosurgeons, oncologists and other scientists in the biomedical field with an interest in neuro-oncology.
Author | : Tod W. Speer |
Publisher | : Lippincott Williams & Wilkins |
Total Pages | : 564 |
Release | : 2012-03-28 |
Genre | : Medical |
ISBN | : 1451153260 |
Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.
Author | : M. Westphal |
Publisher | : Springer Science & Business Media |
Total Pages | : 204 |
Release | : 2003-08-29 |
Genre | : Medical |
ISBN | : 9783211403556 |
In addition to surgery and radiotherapy, local treatment modalities for the management of brain tumours are increasingly being developed and clinically tested. This book describes for the first time basic tumour biology as well as all current procedures in progress at the most recent level of knowledge, presented by leading experts in the respective fields. Image guided resection procedures, fluorescence guided surgery, developments in interstitial radiosurgery are addressed, just as intracavitary chemotherapy and all current concepts and studies of interstitial targeted therapy. Owing to its topicality this book will remain for long the standard for this comprehensively treated subject.
Author | : Evamarie Hey-Hawkins |
Publisher | : John Wiley & Sons |
Total Pages | : 490 |
Release | : 2018-07-23 |
Genre | : Science |
ISBN | : 1119275555 |
Noted experts review the current status of boron-containing drugs and materials for molecular medical diagnostics Boron-Based Compounds offers a summary of the present status and promotes the further development of new boron-containing drugs and advanced materials, mostly boron clusters, for molecular medical diagnostics. The knowledge accumulated during the past decades on the chemistry and biology of bioorganic and organometallic boron compounds laid the foundation for the emergence of a new area of study and application of boron compounds as lipophilic pharmacophores and modulators of biologically active molecules.This important text brings together in one comprehensive volume contributions from renowned experts in the field of medicinal chemistry of boron compounds. The authors cover a range of the most relevant topics including boron compounds as modulators of the bioactivity of biomolecules, boron clusters as pharmacophores or for drug delivery, boron compounds for boron neutron capture therapy (BNCT) and for diagnostics, as well as in silico molecular modeling of boron- and carborane-containing compounds in drug design. Authoritative and accessible, Boron-Based Compounds: Contains contributions from a panel of internationally renowned experts in the field Offers a concise summary of the current status of boron-containing drugs and materials used for molecular diagnostics Highlights the range and capacity of boron-based compounds in medical applications Includes information on boron neutron capture therapy and diagnostics Designed for academic and industrial scientists, this important resource offers the cutting-edge information needed to understand the current state of boron-containing drugs and materials for molecular medical diagnostics.
Author | : Georgios Alexiou |
Publisher | : Springer Nature |
Total Pages | : 861 |
Release | : 2022-01-17 |
Genre | : Medical |
ISBN | : 3030805220 |
This book presents a detailed overview of a spectrum of pediatric neurosurgical conditions. It features detailed insight into the techniques available for examining abnormalities, hemorrhages and a variety of tumors. Relevant surgical methodologies are described in relation to a clinical problem or disorder, ensuring that the reader can systematically develop their knowledge of how to perform both routine and more-obscure procedures presently utilized to treat these conditions. Pediatric Neurosurgery for Clinicians is a comprehensive guide detailing methodologies for applying a range of surgical techniques based upon a range of clinical questions. Therefore, it is a critical resource for all practicing and trainee physicians who encounter children with disorders affecting their neurological systems in disciplines within neurosurgery, neurology, radiology, oncology and pathology.
Author | : Sanjiv Sam Gambhir |
Publisher | : |
Total Pages | : 0 |
Release | : 2015 |
Genre | : |
ISBN | : |
Author | : Prashant Kesharwani |
Publisher | : Academic Press |
Total Pages | : 480 |
Release | : 2018-04-20 |
Genre | : Medical |
ISBN | : 0128122498 |
Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies. - Addresses the progress and challenges inherent in delivering drugs across the blood brain barrier and offers strategies to maximize effectiveness - Draws upon the experience and expertise of international scientists working in the fields of drug delivery and nanomedicine - Considers the future possibilities of nanotechnology for delivering nanocarriers that better diagnose and treat brain tumors
Author | : Michael J. Welch |
Publisher | : CRC Press |
Total Pages | : 390 |
Release | : 2012-02-24 |
Genre | : Science |
ISBN | : 1439841950 |
Targeted Molecular Imaging covers the development of novel diagnostic approaches that use an imaging probe and agent to noninvasively visualize cellular processes in normal and disease states. It discusses the concept, development, preclinical studies, and, in many cases, translation to the clinic of targeted imaging agents. The many case studies that form the core of this book deal with the development and translation of non-nuclear probes and radiotracers; other sections address critical topics such as In vitro studies, small animal research, and the application of targeted probes for nuclear, optical and MRI imaging. The chapters use a common format to demonstrate how various investigators approach the comprehensive task of validating a new targeted probe. Targeted Molecular Imaging is a timely resource for a rapidly advancing field, and addresses: Various methods of validating a new targeted probe through examples from human studies with imaging of breast cancer, cardiovascular disease, and neurodegenerative diseases Basic principles, disease models, imaging studies in animals, imaging in initial human studies, and the application of molecular imaging in pharmacy and drug discovery In vitro studies, small animal studies, and targeted radiopharmaceuticals Using these case studies, investigators can generalize and apply the information to their own specific targeted probe. The insights provided by the contributors, experts who have developed these approaches in their own groups, help guide scientists planning to translate imaging agents from the concept stage to clinical application.
Author | : Giovanni Natile |
Publisher | : MDPI |
Total Pages | : 177 |
Release | : 2018-03-05 |
Genre | : Science |
ISBN | : 3038427578 |
This book is a printed edition of the Special Issue "Translocator Protein (TSPO)" that was published in IJMS
Author | : E. Edmund Kim |
Publisher | : Springer Science & Business Media |
Total Pages | : 302 |
Release | : 2013-06-29 |
Genre | : Medical |
ISBN | : 1475735057 |
This volume is unique in reporting on strategies for the application of molecular targeted imaging agents such as antibodies, peptides, receptors and contrast agents in the biologic grading of tumors, differential diagnosis of tumors, prediction of therapeutic response and monitoring tumor response to treatment. It also includes updated information on the imaging of tumor angiogenesis, hypoxia, apoptosis and gene delivery as well as expression in the understanding and utility of tumor molecular biology for better cancer management.