Preparation of Compounds Labeled with Tritium and Carbon-14

Preparation of Compounds Labeled with Tritium and Carbon-14
Author: Rolf Voges
Publisher: John Wiley & Sons
Total Pages: 682
Release: 2009-03-12
Genre: Science
ISBN: 9780470743430

Compounds labeled with carbon-14 and tritium are indispensable tools for research in biomedical sciences, discovery and development of pharmaceuticals and agrochemicals. Preparation of Compounds Labeled with Tritium and Carbon-14 is a comprehensive, authoritative and up-to-date discussion of the strategies, synthetic approaches, reactions techniques, and resources for the preparation of compounds labeled with either of these isotopes. A large number of examples are presented for the use of isotopic sources and building blocks in the preparation of labeled target compounds, illustrating the range of possibilities for embedding isotopic labels in selected moieties of complex structures. Topics include: Formulation of synthetic strategies for preparing labeled compounds Isotope exchange methods and synthetic alternatives for preparing tritiated compounds In-depth discussion of carbon-14 building blocks and their utility in synthesis Preparation of enantiomerically pure isotopically labeled compounds Applications of biotransformations Preparation of Compounds Labeled with Tritium and Carbon-14 is an essential guide to the specialist strategies and tactics used by chemists to prepare compounds tagged with theradioactive atoms carbon-14 and tritium.

Synthesis and Applications of Isotopically Labelled Compounds 1994

Synthesis and Applications of Isotopically Labelled Compounds 1994
Author: J. Allen
Publisher: Wiley
Total Pages: 990
Release: 1995-08-15
Genre: Science
ISBN: 9780471951438

This work provides a forum for the exchange of information between leading scientists and manufacturers involved in the synthesis and applications of compounds labelled with radioactive and stable isotopes. Contains a general overview of the latest work in the field and its future significance.

Synthesis and Applications of Isotopically Labelled Compounds 1997

Synthesis and Applications of Isotopically Labelled Compounds 1997
Author: J. R. Heys
Publisher:
Total Pages: 776
Release: 1998-06-11
Genre: Reference
ISBN:

Synthesis and Applications of Isotopically Labelled Compounds provides a wide-ranging, authoritative and comprehensive coverage of the most recent advances in the synthesis, production and applications of stable and radioactive isotopes. This volume focuses on significant growth areas including applications of isotopes in clinical research and medicine, advances in the analysis of isotopically labelled compounds, novel approaches to compounds labelled with isotopes of hydrogen, applications of isotopes in organic and bio-organic reaction mechanisms, isotopes in macro-molecules, applications of isotopes in metabolism and toxicology, production of stable isotopes and radioisotopes and applications of isotopes in pharmaceutical and agricultural research. Contributions are drawn from major research groups around the world providing an invaluable information and reference source to anyone involved in the production of isotopes, the synthesis and analysis of stable or radioactive isotopically labelled compounds, the applications of short-lived isotopes, drug metabolism and pharmacokinetics, pharmaceutical research and development, clinical research, biosynthesis, handling radioisotopes, laboratory design and other related areas.

Nuclear and Radiochemistry

Nuclear and Radiochemistry
Author: Karl Heinrich Lieser
Publisher: John Wiley & Sons
Total Pages: 474
Release: 2008-09-26
Genre: Science
ISBN: 3527614184

This new edition of the best-selling handbook gives a complete and concise description of the latest knowledge on nuclear and radiochemistry as well as their applications in the various fields of science. It is based on over 40 years experience in teaching courses and research. The book is aimed at all researchers seeking sound knowledge about the properties of matter, whether chemists, physicists, medical doctors, mineralogists or biologists. All of them will find this a valuable source of information. Research in radiochemistry includes: Study of radioactive matter in nature, investigation of radioactive transmutations, chemistry of radioelements etc. Applications include: Radionuclides in geo- and cosmochemistry, dating by nuclear methods, radioanalysis, Mossbauer spectroscopy and related methods, behavior of natural and man-made radionuclides in the environment, dosimetry and radiation protection. All the subjects are presented clearly and comprehensibly, and in a logical sequence, avoiding detailed derivations of equations. The relevant information is compiled in tables and the recent edition of the multi-colored Karlsruhe 'Chart of the Nuclides' has also been included. Clearly a standard work by an author with extensive experience in research and teaching.

Research Instrumentation for the 21st Century

Research Instrumentation for the 21st Century
Author: Gary R. Beecher
Publisher: Springer Science & Business Media
Total Pages: 458
Release: 2012-12-06
Genre: Science
ISBN: 9400927487

The Annual Beltsville Symposium serves as a forum for presenting recent developments in basic research that contribute solutions to agricultural problems. The eleventh in this series focuses on instrumentation tech niques which provide powerful new research tools. These tools will provide information that can lead to a better understanding of biological and physical processes critical to the solution of today's agricultural problems. The tools discussed include isotope technology, separation techniques, microscopy, electro-magnetic spectroscopy, resonance and mass spectrometry and microcomputers. This Symposium brought together scientists who are at the forefront of the development of many of these tools and those who are applying them to problems directly related to agricultural research. WALDEMAR KLASSEN, Director Beltsville Area VII CONTRIBUTORS AND THEIR AFFILIATIONS Norman G. Anderson Youhanna Fares Proteus Technologies, Inc. Phytokinetics Inc. Rockville, MD 20852 College Station, TX 77840 U.S.A. U.S.A. Cherie L. Fisk Edwin D. Becker Office of Research Services Office of Research Services NIH NIH Bethesda, MD 20892 Bethesda, MD 20892 U.S.A. U.S.A. Klaus Biemann John D. Goeschl Phytokinetics, Ltd. Department of Chemistry College Station, TX 77840 Massachusetts Institute of Technology Cambridge, MA 02139 U.S.A. U.S.A. R.J. Griesbach Florist and Nursery Crops Laboratory B.A. Bolton Development Quality Laboratory Horticultural Science Institute Agricultural Research Service USDA Western Regional Research Center Beltsville, MD 20705 Agricultural Research Service USDA U.S.A. Albany, CA 94710 U.S.A.

New Trends in Radiopharmaceutical Synthesis, Quality Assurance, and Regulatory Control

New Trends in Radiopharmaceutical Synthesis, Quality Assurance, and Regulatory Control
Author: Ali M. Emran
Publisher: Springer Science & Business Media
Total Pages: 504
Release: 2013-11-09
Genre: Medical
ISBN: 1489906266

Marking the 200th National Meeting of the American Chemical Society, The Division of Nuclear Chemistry and Technology hosted a group of about 90 scientists from 15 different countries to discuss the new trends in radiopharmaceutical synthesis, quality assurance and regulatory control. This event took place in Washington, D.C. on August 27-30, 1990. When I first suggested the idea for this symposium, a group of scientists who pioneered the proposed topics offered their help to organize and run such a big task with me. Their names are listed here in appreciation. Thomas E. Boothe Cyclotron Facility, Mt. Sinai Medical Center, Miami Beach, Florida, USA Robert F. Dannals Division of Nuclear Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA Anthony L. Feliu Julich Nuclear Research Center, Julich, Germany Joanna S. Fowler Chemistry Department, Brookhaven National Laboratory, Upton, New York, USA George W. Kabalka Department of Chemistry, University of Tennessee, Knoxville, Tennessee, USA Hank F. Kung Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA James F. Lamb Imagents, Inc., Houston, Texas, USA Harold A. O'Brien, Jr. Los Alamos National Laboratory, Los Alamos, New Mexico, USA Joseph R. Peterson Dept. of Chemistry, University of Tennessee, Knoxville, Tennessee, USA Hernan Vera Ruiz International Atomic Energy Agency, Vienna, Austria Roy S. Tilbury University of Texas, M. D. Anderson Cancer Center, Houston, Texas, USA In addition, a number of distinguished colleagues have participated in the process of reviewing the manuscripts presented in this volume. Their effort is sincerely acknowledged.