Studies On Chromosomes
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Author | : Adrian T. Sumner |
Publisher | : John Wiley & Sons |
Total Pages | : 304 |
Release | : 2008-04-30 |
Genre | : Science |
ISBN | : 0470695226 |
Integrating classical knowledge of chromosome organisation with recent molecular and functional findings, this book presents an up-to-date view of chromosome organisation and function for advanced undergraduate students studying genetics. The organisation and behaviour of chromosomes is central to genetics and the equal segregation of genes and chromosomes into daughter cells at cell division is vital. This text aims to provide a clear and straightforward explanation of these complex processes. Following a brief historical introduction, the text covers the topics of cell cycle dynamics and DNA replication; mitosis and meiosis; the organisation of DNA into chromatin; the arrangement of chromosomes in interphase; euchromatin and heterochromatin; nucleolus organisers; centromeres and telomeres; lampbrush and polytene chromosomes; chromosomes and evolution; chromosomes and disease, and artificial chromosomes. Topics are illustrated with examples from a wide variety of organisms, including fungi, plants, invertebrates and vertebrates. This book will be valuable resource for plant, animal and human geneticists and cell biologists. Originally a zoologist, Adrian Sumner has spent over 25 years studying human and other mammalian chromosomes with the Medical Research Council (UK). One of the pioneers of chromosome banding, he has used electron microscopy and immunofluorescence to study chromosome organisation and function, and latterly has studied factors involved in chromosome separation at mitosis. Adrian is an Associate Editor of the journal Chromosome Research, acts as a consultant biologist and is also Chair of the Committee of the International Chromosome Conferences. The most up-to-date overview of chromosomes in all their forms. Introduces cutting-edge topics such as artificial chromosomes and studies of telomere biology. Describes the methods used to study chromosomes. The perfect complement to Turner.
Author | : Soraya de Chadarevian |
Publisher | : University of Chicago Press |
Total Pages | : 318 |
Release | : 2020-07-02 |
Genre | : Science |
ISBN | : 022668511X |
By focusing on chromosomes, Heredity under the Microscope offers a new history of postwar human genetics. Today chromosomes are understood as macromolecular assemblies and are analyzed with a variety of molecular techniques. Yet for much of the twentieth century, researchers studied chromosomes by looking through a microscope. Unlike any other technique, chromosome analysis offered a direct glimpse of the complete human genome, opening up seemingly endless possibilities for observation and intervention. Critics, however, countered that visual evidence was not enough and pointed to the need to understand the molecular mechanisms. Telling this history in full for the first time, Soraya de Chadarevian argues that the often bewildering variety of observations made under the microscope were central to the study of human genetics. Making space for microscope-based practices alongside molecular approaches, de Chadarevian analyzes the close connections between genetics and an array of scientific, medical, ethical, legal, and policy concerns in the atomic age. By exploring the visual evidence provided by chromosome research in the context of postwar biology and medicine, Heredity under the Microscope sheds new light on the cultural history of the human genome.
Author | : Rudi Appels |
Publisher | : Springer Science & Business Media |
Total Pages | : 405 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 1461554098 |
Chromosome biology has been brought to a golden age by phenomenal advanced in molecular genetics and techniques. This is true in the plant arena, and it is becoming increasingly true in animal studies, where chromosomes are more difficult to work with. With advanced knowledge of transformation, scientists can tell exactly where a new element enters a chromosome. Conversely, molecular biologists can make large mistakes if they do not understand the behavior of chromosomes. Written by internationally recognized experts in the field, this book is the most authoritative work on the subject to date. Students of genetics, crop science and plant breeding, entomology, animal science, and related fields will benefit from this comprehensive and practical textbook.
Author | : Edmund Beecher Wilson |
Publisher | : |
Total Pages | : 434 |
Release | : 1905 |
Genre | : Chromosomes |
ISBN | : |
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 287 |
Release | : 2001-07-02 |
Genre | : Medical |
ISBN | : 0309132975 |
It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.
Author | : A. Lima-de-Faria |
Publisher | : Springer Science & Business Media |
Total Pages | : 196 |
Release | : 2013-06-29 |
Genre | : Science |
ISBN | : 9401701679 |
One Hundred Years of Chromosome Research: What Remains to be Learned, offers the reader a critical analysis of the observations and experiments that shaped the last 100 years of chromosome research, as well as the ideas which prevailed during this period. Emphasis is placed on what remains to be learned, particularly in light of reality of the sequencing of DNA which leaves the previous era of chromosome research as a prehistoric event. It is at this turning point, that well formulated questions can be asked about many of the chromosome's properties, which remain to be unveiled. The author, Lima-de-Faria is Professor Emeritus of Molecular Cytogenetics at Lund Unviersity, Sweden, previously Head of the Institute of Molecular Cytogenetics, Lund University.
Author | : Bruce Alberts |
Publisher | : |
Total Pages | : 0 |
Release | : 2002 |
Genre | : Cytology |
ISBN | : 9780815332183 |
Author | : Kenneth W. Adolph |
Publisher | : CRC Press |
Total Pages | : 488 |
Release | : 1991-03-28 |
Genre | : Science |
ISBN | : 9780824784300 |
Contributors detail up-to-date guidelines for using molecular techniques, cytogenetic and linkage analysis, and cellular methods, emphasizing human cells and medically relevant research. They present results of recent applications of techniques and step-by-step protocols for cloning large DNA molecu
Author | : Nettie Maria Stevens |
Publisher | : |
Total Pages | : 66 |
Release | : 1905 |
Genre | : Sex |
ISBN | : |
Author | : Arun Sharma |
Publisher | : Butterworth-Heinemann |
Total Pages | : 724 |
Release | : 2014-04-24 |
Genre | : Science |
ISBN | : 1483100847 |
Chromosome Techniques: Theory and Practice, Third Edition focuses on chromosome research. The book first discusses pre-treatment and hypotonic treatment. Pre-treatment for clearing the cytoplasm and softening the tissues; separation of chromosomes and clarification of constrictions; and hypotonic treatment for chromosome spread are described. The text also explains fixation and processing, including fixing of fluids and mixtures and air-drying techniques for chromosome study. The selection also discusses methods for special materials. Study of division in embryosac mother cells; study of chromosomes from thallophytes; salivary gland, lamp brush, and pachytene chromosomes; spiral structure; and secondary constriction are explained. The text also discusses microscopy, including ordinary light microscopy, high resolution autoradiography, and light microscope autoradiography. The book discusses study of plant chromosomes from tissue culture; chromosome analysis following short- and long-term cultures in animals, including man; and chromosome analysis from malignant tissues. The text takes a look at the banding patterns of chromosomes, including banding pattern techniques, C-banding, and representative schedules for comparative study of different banding patterns. The book further describes somatic cell fusion and the chemical nature of chromosomes, proteins, and enzymes. The text is a vital source of information for readers wanting to conduct research on chromosomes.