This volume comprises 17 contributions that address the architecture and geodynamic evolution of the Himalaya–Karakoram–Tibet (HKT) system, covering wide aspects, from the active seismicity of the present day to the remnants of the Proterozoic orogen. The articles investigate the HKT system at different scales, blending field research with laboratory studies. The role of various lithospheric components and their inheritance in the geodynamic and magmatic evolution of the HKT system through time, and their links to global geological events, are studied in the field. The laboratory research focuses on the (sub-)micrometre scale, detailing micro-structural geology, crystal chemistry, geochronology, and the study of circulating fluids, their preservation (trapped in fluid inclusions) and their evolution, distribution, migration and interaction with the solid host. An orogen over 2000 km long can be understood only if the processes at the nanometre and micrometre scales are taken into account. The contributions in this volume successfully combine these scales to enhance our understanding of the HKT system.