Statistical Methods For Expression Quantitative Trait Loci Eqtl Mapping
Download Statistical Methods For Expression Quantitative Trait Loci Eqtl Mapping full books in PDF, epub, and Kindle. Read online free Statistical Methods For Expression Quantitative Trait Loci Eqtl Mapping ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
| Author | : Xinghua Mindy Shi |
| Publisher | : Humana |
| Total Pages | : 252 |
| Release | : 2021-01-02 |
| Genre | : Science |
| ISBN | : 9781071600283 |
This volume details state-of-art eQTL analysis, where interdisciplinary researchers are provided both theoretical and practical guidance to eQTL analysis and interpretation. Chapters guide readers through methods and tools for eQTL and QTL analysis and the usage of such analysis in various scenarios. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, eQTL Analysis: Methods and Protocols to ensure successful results in the further study of this vital field.
| Author | : Zehua Chen |
| Publisher | : CRC Press |
| Total Pages | : 308 |
| Release | : 2016-04-19 |
| Genre | : Mathematics |
| ISBN | : 143986831X |
While numerous advanced statistical approaches have recently been developed for quantitative trait loci (QTL) mapping, the methods are scattered throughout the literature. Statistical Methods for QTL Mapping brings together many recent statistical techniques that address the data complexity of QTL mapping. After introducing basic genetics topics an
| Author | : Jacob Peedicayil |
| Publisher | : Academic Press |
| Total Pages | : 848 |
| Release | : 2021-08-21 |
| Genre | : Science |
| ISBN | : 0128235780 |
Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. - Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease - Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins - Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery - Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) - Features chapter contributions from international leaders in the field
| Author | : Meng Chen |
| Publisher | : |
| Total Pages | : 164 |
| Release | : 2006 |
| Genre | : |
| ISBN | : |
| Author | : Jianfeng Feng |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 411 |
| Release | : 2010-06-14 |
| Genre | : Science |
| ISBN | : 1849961964 |
Biological and biomedical studies have entered a new era over the past two decades thanks to the wide use of mathematical models and computational approaches. A booming of computational biology, which sheerly was a theoretician’s fantasy twenty years ago, has become a reality. Obsession with computational biology and theoretical approaches is evidenced in articles hailing the arrival of what are va- ously called quantitative biology, bioinformatics, theoretical biology, and systems biology. New technologies and data resources in genetics, such as the International HapMap project, enable large-scale studies, such as genome-wide association st- ies, which could potentially identify most common genetic variants as well as rare variants of the human DNA that may alter individual’s susceptibility to disease and the response to medical treatment. Meanwhile the multi-electrode recording from behaving animals makes it feasible to control the animal mental activity, which could potentially lead to the development of useful brain–machine interfaces. - bracing the sheer volume of genetic, genomic, and other type of data, an essential approach is, ?rst of all, to avoid drowning the true signal in the data. It has been witnessed that theoretical approach to biology has emerged as a powerful and st- ulating research paradigm in biological studies, which in turn leads to a new - search paradigm in mathematics, physics, and computer science and moves forward with the interplays among experimental studies and outcomes, simulation studies, and theoretical investigations.
| Author | : Robert T. Gerlai |
| Publisher | : Academic Press |
| Total Pages | : 710 |
| Release | : 2018-04-24 |
| Genre | : Science |
| ISBN | : 0128041161 |
Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists. - Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials - Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior - Written and edited by leading international experts
| Author | : Krishnarao Appasani |
| Publisher | : Cambridge University Press |
| Total Pages | : 449 |
| Release | : 2016-01-14 |
| Genre | : Medical |
| ISBN | : 1107042763 |
Experts from academia and industry highlight the potential of genome-wide association studies from basic science to clinical and biotechnological/pharmaceutical applications.
| Author | : Tony Cai;Xiaotong Shen |
| Publisher | : |
| Total Pages | : 318 |
| Release | : |
| Genre | : |
| ISBN | : 9787894236326 |
Over the last few years, significant developments have been taking place in highdimensional data analysis, driven primarily by a wide range of applications in many fields such as genomics and signal processing. In particular, substantial advances have been made in the areas of feature selection, covariance estimation, classification and regression. This book intends to examine important issues arising from highdimensional data analysis to explore key ideas for statistical inference and prediction. It is structured around topics on multiple hypothesis testing, feature selection, regression, cla.
| Author | : Trygve Tollefsbol |
| Publisher | : Academic Press |
| Total Pages | : 944 |
| Release | : 2016-06-21 |
| Genre | : Science |
| ISBN | : 0128032405 |
Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine
| Author | : Michael Lynch |
| Publisher | : Sinauer Associates Incorporated |
| Total Pages | : 980 |
| Release | : 1998-01 |
| Genre | : Science |
| ISBN | : 9780878934812 |
Professors Lynch and Walsh bring together the diverse array of theoretical and empirical applications of quantitative genetics in a work that is comprehensive and accessible to anyone with a rudimentary understanding of statistics and genetics.
