Spontaneous Animal Models Of Human Disease
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Author | : Edwin J. Andrews |
Publisher | : |
Total Pages | : 360 |
Release | : 1979 |
Genre | : Medical |
ISBN | : |
This two-volume work gathers together the diverse information presently available on spontaneous animal models of human disease. In addition to providing a comprehensive review of existing models, the book presents many previous unpublished new models. The scope of this work is limited to spontaneous models. Neoplasia, infectious diseases including parasitism, and nutritionally induced or other types of experimental models have not been included. The sixteen parts of the book are alphabetically arranged according to organ system with over 230 authors contributing to the overall effort. In addition to many illustrations, the book features an extensive bibliography.
Author | : Edwin J. Andrews |
Publisher | : |
Total Pages | : 372 |
Release | : 1979 |
Genre | : Medical |
ISBN | : |
Author | : Edwin J. Andrews |
Publisher | : Elsevier |
Total Pages | : 345 |
Release | : 2012-12-02 |
Genre | : Science |
ISBN | : 0323138284 |
This two-volume work gathers together the diverse information presently available on spontaneous animal models of human disease. In addition to providing a comprehensive review of existing models, the book presents many previous unpublished new models.The scope of this work is limited to spontaneous models. Neoplasia, infectious diseases including parasitism, and nutritionally induced or other types of experimental models have not been included. The sixteen parts of the book are alphabetically arranged according to organ system with over 230 authors contributing to the overall effort. In addition to many illustrations, the book features an extensive bibliography.
Author | : EJ ANDREWS (Ed) |
Publisher | : |
Total Pages | : |
Release | : 1979 |
Genre | : |
ISBN | : |
Author | : Registry of Comparative Pathology |
Publisher | : |
Total Pages | : 280 |
Release | : 1993 |
Genre | : Animal models in research |
ISBN | : |
Author | : |
Publisher | : Academic Press |
Total Pages | : 551 |
Release | : 2011-03-04 |
Genre | : Science |
ISBN | : 0123848792 |
Animal experiments have contributed much to our understanding of mechanisms of disease and are important for determining new therapies. Animal Models of Human Disease reviews the latest research and developments in this field. Discusses new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields
Author | : EJ ANDREWS (Ed) |
Publisher | : |
Total Pages | : |
Release | : 1979 |
Genre | : |
ISBN | : |
Author | : Yoichi Gondo |
Publisher | : Elsevier Inc. Chapters |
Total Pages | : 71 |
Release | : 2013-05-29 |
Genre | : Medical |
ISBN | : 0128072245 |
To create and establish mutant mice as models for human diseases and traits, various forward and reverse genetics tools are currently available. Newly developed tools of high-throughput identification of novel mutations and site-directed mutagenesis, or gene targeting, in the mouse genome have caused forward and reverse genetics, respectively, to rapidly expand during the last two decades. Worldwide efforts including a variety of international consortiums have been producing many useful mutant mouse strains for functional genomics to elucidate the mechanisms behind diseases and traits. Resource centers and public databases have also been built to enhance their utilities. The modeling has started from Mendelian monogenic traits and has expanded to more complex quantitative traits as well. Multidisciplinary integration among, for example, molecular, cellular, and developmental biology; genetics; genomics; medicine; statistics; and informatics must be orchestrated to fully utilize the resources and knowledge of model mice.
Author | : Judith Axler Turner |
Publisher | : Elsevier Inc. Chapters |
Total Pages | : 28 |
Release | : 2013-05-29 |
Genre | : Medical |
ISBN | : 0128071923 |
Identifying and selecting the most appropriate animal model is a challenge, but the U.S. Federal Government’s National Institutes of Health, has supported several efforts to make the job of finding disease models easier. These efforts began with support for databases about specific species, and have graduated to support for discipline-specific studies and cross-species resources. This article tracks LAMHDI, the initiative to Link Animal Models to Human DIsease (www.lamhdi.org), which brings together data about five species: flies, mice, rats, yeast, and zebrafish, and allows scientists to search across these data, principally by disease and gene. This chapter explains how LAMHDI was conceived, and where LAMHDI hopes to go in moving into phenotypical as well as genotypical data through networks and visualization.
Author | : Sara I. Ruiz |
Publisher | : Elsevier Inc. Chapters |
Total Pages | : 116 |
Release | : 2013-05-29 |
Genre | : Medical |
ISBN | : 0128072288 |
As the threat of exposure to emerging and reemerging viruses within a naive population increases, it is vital that the basic mechanisms of pathogenesis and immune response be thoroughly investigated. By using animal models in this endeavor, the response to viruses can be studied in a more natural context to identify novel drug targets, and assess the efficacy and safety of new products. This is especially true in the advent of the Food and Drug Administration's animal rule. Although no one animal model is able to recapitulate all the aspects of human disease, understanding the current limitations allows for a more targeted experimental design. Important facets to be considered before an animal study are the route of challenge, species of animals, biomarkers of disease, and a humane endpoint. This chapter covers the current animal models for medically important human viruses, and demonstrates where the gaps in knowledge exist.