Smart External Stimulus Responsive Na
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| Author | : Mahdi Karimi |
| Publisher | : Morgan & Claypool Publishers |
| Total Pages | : 114 |
| Release | : 2015-12-01 |
| Genre | : Science |
| ISBN | : 1681740109 |
The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo, this can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by enzymes in the body, to enhance the solubility of insoluble drugs, to extend the circulation half-life, and to enhance its penetration and accumulation at the target site. Importantly, smart nanocarriers can be designed to be responsive to a specific stimulus, so that the cargo is only released or activated when desired. In this volume we cover smart nanocarriers that respond to externally applied stimuli that usually involve application of physical energy. This physical energy can be applied from outside the body and can either cause cargo release, or can activate the nanostructure to be cytotoxic, or both. The stimuli covered include light of various wavelengths (ultraviolet, visible or infrared), temperature (increased or decreased), magnetic fields (used to externally manipulate nanostructures and to activate them), ultrasound, and electrical and mechanical forces. Finally we discuss the issue of nanotoxicology and the future scope of the field.
| Author | : Mahdi Karimi |
| Publisher | : Morgan & Claypool Publishers |
| Total Pages | : 112 |
| Release | : 2015-12-01 |
| Genre | : Science |
| ISBN | : 1681742578 |
The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo. This can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by enzymes in the body, to enhance the solubility of insoluble drugs, to extend the circulation half-life, and to enhance its penetration and accumulation at the target site. Importantly, smart nanocarriers can be designed to be responsive to a specific stimulus, so that the cargo is only released or activated when desired. In this volume we cover smart nanocarriers that respond to internal stimuli that are intrinsic to the target site. These stimuli are specific to the cell type, tissue or organ type, or to the disease state (cancer, infection, inflammation etc). pH-responsive nanostructures can be used for cargo release in acidic endosomal compartments, in the lower pH of tumors, and for specific oral delivery either to the stomach or intestine. Nanocarriers can be designed to be substrates of a wide-range of enzymes that are over-expressed at disease sites. Oxidation and reduction reactions can be taken advantage of in smart nanocarriers by judicious molecular design. Likewise, nanocarriers can be designed to respond to a range of specific biomolecules that may occur at the target site. In this volume we also cover dual and multi-responsive systems that combine stimuli that could be either internal or external.
| Author | : Raju Francis |
| Publisher | : John Wiley & Sons |
| Total Pages | : 414 |
| Release | : 2016-12-19 |
| Genre | : Technology & Engineering |
| ISBN | : 3527338365 |
With its content taken from only the very latest results, this is an extensive summary of the various polymeric materials used for biomedical applications. Following an introduction listing various functional polymers, including conductive, biocompatible and conjugated polymers, the book goes on to discuss different synthetic polymers that can be used, for example, as hydrogels, biochemical sensors, functional surfaces, and natural degradable materials. Throughout, the focus is on applications, with worked examples for training purposes as well as case studies included. The whole is rounded off with a look at future trends.
| Author | : Vivek Dave |
| Publisher | : John Wiley & Sons |
| Total Pages | : 467 |
| Release | : 2020-12-29 |
| Genre | : Computers |
| ISBN | : 1119711681 |
The book provides a single volume covering detailed descriptions about various delivery systems, their principles and how these are put in use for the treatment of multiple diseases. It is divided into four sections where the first section deals with the introduction and importance of novel drug delivery system. The second section deals with the most advanced drug delivery systems like microbubbles, dendrimers, lipid-based nanoparticles, nanofibers, microemulsions etc., describing the major principles and techniques of the preparations of the drug delivery systems. The third section elaborates on the treatments of diverse diseases like cancer, topical diseases, tuberculosis etc. The fourth and final section provides a brief informative description about the regulatory aspects of novel drug delivery system that is followed in various countries.
| Author | : Andrea Cusano |
| Publisher | : Springer |
| Total Pages | : 377 |
| Release | : 2014-07-29 |
| Genre | : Science |
| ISBN | : 3319069985 |
This book focuses on a research field that is rapidly emerging as one of the most promising ones for the global optics and photonics community: the “lab-on-fiber” technology. Inspired by the well-established "lab on-a-chip" concept, this new technology essentially envisages novel and highly functionalized devices completely integrated into a single optical fiber for both communication and sensing applications. Based on the R&D experience of some of the world's leading authorities in the fields of optics, photonics, nanotechnology, and material science, this book provides a broad and accurate description of the main developments and achievements in the lab-on-fiber technology roadmap, also highlighting the new perspectives and challenges to be faced. This book is essential for scientists interested in the cutting-edge fiber optic technology, but also for graduate students.
| Author | : Lacramioara Popa |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 133 |
| Release | : 2019-04-10 |
| Genre | : Technology & Engineering |
| ISBN | : 1789858755 |
Hydrogels, as three-dimensional polymer networks, are able to retain a large amount of water in their swollen state. The biomedical application of hydrogels was initially hampered by the toxicity of cross-linking agents and the limitations of hydrogel formation under physiological conditions. However, emerging knowledge in polymer chemistry and an increased understanding of biological processes have resulted in the design of versatile materials and minimally invasive therapies.The novel but challenging properties of hydrogels are attracting the attention of researchers in the biological, medical, and pharmaceutical fields. In the last few years, new methods have been developed for the preparation of hydrophilic polymers and hydrogels, which may be used in future biomedical and drug delivery applications. Such efforts include the synthesis of self-organized nanostructures based on triblock copolymers with applications in controlled drug delivery. These hydrogels could be used as carriers for drug delivery when combined with the techniques of drug imprinting and subsequent release. Engineered protein hydrogels have many potential advantages. They are excellent biomaterials and biodegradables. Furthermore, they could encapsulate drugs and be used in injectable forms to replace surgery, to repair damaged cartilage, in regenerative medicine, or in tissue engineering. Also, they have potential applications in gene therapy, although this field is relatively new.
| Author | : Showkat Ahmad Bhawani |
| Publisher | : Woodhead Publishing |
| Total Pages | : 484 |
| Release | : 2020-11-28 |
| Genre | : Technology & Engineering |
| ISBN | : 0128204354 |
Smart Polymer Nanocomposites: Biomedical and Environmental Applications presents the latest information on smart polymers and their promising application in various fields, including their role in delivery systems for drugs, tissue engineering scaffolds, cell culture sports, bioseparation, and sensors or actuator systems. - Features detailed information on the preparation, characterization and applications of smart functional polymer composites - Covers a broad range of applications in both the biomedical and environmental engineering fields - Chapters are written by authors with diverse background expertise from the faculties of chemistry, engineering and the manufacturing industry
| Author | : Abdel Salam Hamdy Makhlouf |
| Publisher | : Woodhead Publishing |
| Total Pages | : 694 |
| Release | : 2018-06-14 |
| Genre | : Technology & Engineering |
| ISBN | : 008101998X |
Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications, Volume One: Types and Triggers discusses, in detail, the recent trends in designing biodegradable and biocompatible single-responsive polymers and nanoparticles for safe drug delivery. Focusing on the most advanced materials and technologies, evaluation methods, and advanced synthesis techniques stimuli-responsive polymers, the book is an essential reference for scientists with an interest in drug delivery vehicles. Sections focus on innovation, development and the increased global demand for biodegradable and biocompatible responsive polymers and nanoparticles for safe drug delivery. - Offers an in-depth look at the basic and fundamental aspects of alternative stimuli-responsive polymers, mechanisms, structure, synthesis and properties - Provides a well-defined categorization for stimuli-responsive polymers for drug delivery based on different triggering mechanisms - Discusses novel approaches and challenges for scaling up and commercialization of stimuli-responsive polymers
| Author | : Liang Hu |
| Publisher | : John Wiley & Sons |
| Total Pages | : 404 |
| Release | : 2022-08-02 |
| Genre | : Technology & Engineering |
| ISBN | : 3527832394 |
Smart Stimuli-Responsive Poymers, Films, and Gels Discover the most important developments in synthesis, simulation, and applications of a fascinating compound class There exist a range of natural materials that respond to environmental changes by altering their physical or chemical properties, known as stimuli-responsive polymers, these substances are responsive to light, temperature, pressure, and more. The study of these so-called “smart” polymers is essential to a range of application fields, many of which have generated cutting-edge research in recent decades. A comprehensive introduction to the subject is therefore well-timed Smart Stimuli-Responsive Polymers, Films, and Gels provides an introduction to these polymers and their applications. It includes producing these polymers through synthetic approaches, simulating their responses to different stimuli, and applying these materials in different industries and research capacities. Written to serve the requirements of advanced students and senior researchers alike, this timely work will drive years of research in this vital field. In Smart Stimuli-Responsive Polymers, Films, and Gels readers will also find: Treatment of mechanoresponsive, photoresponsive, and ionizing-radiation responsive polymers Applications in emerging fields such as sensors, biomedicine, catalysis, and more Interdisciplinary research into the properties and responses of these vital compounds Smart Stimuli-Responsive Polymers, Films, and Gels promises to become a seminal work for chemists, materials scientists, and industrial researchers seeking to incorporate these materials into a variety of industrial and research areas.
| Author | : Ajit Behera |
| Publisher | : CRC Press |
| Total Pages | : 435 |
| Release | : 2024-08-27 |
| Genre | : Technology & Engineering |
| ISBN | : 1040032168 |
Smart drug delivery at both the micro- and nanoscale is an evolving field with numerous potential applications. It has the potential to revolutionize drug therapy by making treatments more effective, reducing side effects, and improving patient outcomes. This book presents a comprehensive review of the most recent studies on smart micro- and nanomaterials with a focus on their “smart” activity for formation of targeted and responsive drug-delivery carriers. This volume: Introduces readers to the fundamentals of these the micro- and nanoscale materials as well as approaches to smart drug delivery and drug delivery systems. Covers polymers, metals, and composite materials as well as quantum dots and carbon nanotubes. Describes of all possible stimulated systems for drug delivery such as enzyme-responsive, small molecules-responsive, thermo-responsive, pH-responsive, electric field-responsive, magnetic field-responsive, light-responsive, ultrasound-responsive, and reductive environment responsive. Offers a critical perspective on the future scope of smart drug delivery systems. This reference work is written to support researchers in the fields of materials engineering and biotechnology with the goal of improving the diagnosis and treatment of disease and patient quality of life.
