During the eighteenth and nineteenth centuries, the Caribbean was known as the 'grave of Europeans'. At the apex of British colonialism in the region between 1764 and 1834, the rapid spread of disease amongst colonist, enslaved and indigenous populations made the Caribbean notorious as one of the deadliest places on earth. Drawing on historical accounts from physicians, surgeons and travellers alongside literary works, Emily Senior traces the cultural impact of such widespread disease and death during the Romantic age of exploration and medical and scientific discovery. Focusing on new fields of knowledge such as dermatology, medical geography and anatomy, Senior shows how literature was crucial to the development and circulation of new medical ideas, and that the Caribbean as the hub of empire played a significant role in the changing disciplines and literary forms associated with the transition to modernity.