The health disparities affecting Indigenous peoples in Canada might well be understood as a national epidemic. Although progress has been made in the last decade towards both understanding and ameliorating Indigenous health inequalities, very little research or writing has expanded a social determinants of health framework to account for the unique histories and present realities of Indigenous peoples in this country. This timely edited collection addresses this significant knowledge gap, exploring the ways that multiple health determinants beyond the social-from colonialism to geography, from economy to biology-converge to impact the health status of Indigenous peoples in Canada. This unique collection, comprised largely of contributions by Indigenous authors, offers the voices and expertise of First Nations, Inuit, and Metis writers from across Canada. The multitude of health determinants of Indigenous peoples are considered in a selection of chapters that range from scholarly papers by research experts in the field, to reflective essays by Indigenous leaders. Appropriate throughout a range of disciplines, including Health Studies, Indigenous Studies, Public and Population Health, Community Health Sciences, Medicine, Nursing, and Social Work, this engaging text broadens the social determinants of health framework to better understand health inequality. Most importantly, it does so by placing front and center the voices and experiences of Indigenous peoples.