Sequential Design of Experiments for Nonlinear Models

Sequential Design of Experiments for Nonlinear Models
Author: G. E. P. BOX
Publisher:
Total Pages: 36
Release: 1963
Genre:
ISBN:

To engineers, basic mechanism studies are of interest principally because a deeper understanding makes it possible to cope with engineering design problems in a more intelligent and useful manner than would be possible if the mechanism were entirely unknown. Such mechanism studies consist essentially of two steps: (i) establishing an adequate form for the theoretical model and then (ii) determining precisely the values of its parameters. In this paper it is supposed that step (i) has been accomplished and the form of the theoretical model is therefore known. The problem which confronts the experimenter now is the evaluation of the physical parameters (e.g., rate constants in chemical kinetics examples). The purpose of this paper is to consider the problem of generation of data, i.e., the statistical design of experiments.

Design of Experiments in Nonlinear Models

Design of Experiments in Nonlinear Models
Author: Luc Pronzato
Publisher: Springer Science & Business Media
Total Pages: 404
Release: 2013-04-10
Genre: Medical
ISBN: 1461463637

Design of Experiments in Nonlinear Models: Asymptotic Normality, Optimality Criteria and Small-Sample Properties provides a comprehensive coverage of the various aspects of experimental design for nonlinear models. The book contains original contributions to the theory of optimal experiments that will interest students and researchers in the field. Practitionners motivated by applications will find valuable tools to help them designing their experiments. The first three chapters expose the connections between the asymptotic properties of estimators in parametric models and experimental design, with more emphasis than usual on some particular aspects like the estimation of a nonlinear function of the model parameters, models with heteroscedastic errors, etc. Classical optimality criteria based on those asymptotic properties are then presented thoroughly in a special chapter. Three chapters are dedicated to specific issues raised by nonlinear models. The construction of design criteria derived from non-asymptotic considerations (small-sample situation) is detailed. The connection between design and identifiability/estimability issues is investigated. Several approaches are presented to face the problem caused by the dependence of an optimal design on the value of the parameters to be estimated. A survey of algorithmic methods for the construction of optimal designs is provided.

Optimal Experimental Design for Non-Linear Models

Optimal Experimental Design for Non-Linear Models
Author: Christos P. Kitsos
Publisher: Springer Science & Business Media
Total Pages: 104
Release: 2014-01-09
Genre: Mathematics
ISBN: 3642452876

This book tackles the Optimal Non-Linear Experimental Design problem from an applications perspective. At the same time it offers extensive mathematical background material that avoids technicalities, making it accessible to non-mathematicians: Biologists, Medical Statisticians, Sociologists, Engineers, Chemists and Physicists will find new approaches to conducting their experiments. The book is recommended for Graduate Students and Researchers.

Model-Oriented Design of Experiments

Model-Oriented Design of Experiments
Author: Valerii V. Fedorov
Publisher: Springer Science & Business Media
Total Pages: 120
Release: 2012-12-06
Genre: Mathematics
ISBN: 1461207037

Here, the authors explain the basic ideas so as to generate interest in modern problems of experimental design. The topics discussed include designs for inference based on nonlinear models, designs for models with random parameters and stochastic processes, designs for model discrimination and incorrectly specified (contaminated) models, as well as examples of designs in functional spaces. Since the authors avoid technical details, the book assumes only a moderate background in calculus, matrix algebra, and statistics. However, at many places, hints are given as to how readers may enhance and adopt the basic ideas for advanced problems or applications. This allows the book to be used for courses at different levels, as well as serving as a useful reference for graduate students and researchers in statistics and engineering.

Handbook of Design and Analysis of Experiments

Handbook of Design and Analysis of Experiments
Author: Angela Dean
Publisher: CRC Press
Total Pages: 946
Release: 2015-06-26
Genre: Mathematics
ISBN: 146650434X

This carefully edited collection synthesizes the state of the art in the theory and applications of designed experiments and their analyses. It provides a detailed overview of the tools required for the optimal design of experiments and their analyses. The handbook covers many recent advances in the field, including designs for nonlinear models and algorithms applicable to a wide variety of design problems. It also explores the extensive use of experimental designs in marketing, the pharmaceutical industry, engineering and other areas.

Optimal Design of Experiments

Optimal Design of Experiments
Author: Peter Goos
Publisher: John Wiley & Sons
Total Pages: 249
Release: 2011-06-28
Genre: Science
ISBN: 1119976162

"This is an engaging and informative book on the modern practice of experimental design. The authors' writing style is entertaining, the consulting dialogs are extremely enjoyable, and the technical material is presented brilliantly but not overwhelmingly. The book is a joy to read. Everyone who practices or teaches DOE should read this book." - Douglas C. Montgomery, Regents Professor, Department of Industrial Engineering, Arizona State University "It's been said: 'Design for the experiment, don't experiment for the design.' This book ably demonstrates this notion by showing how tailor-made, optimal designs can be effectively employed to meet a client's actual needs. It should be required reading for anyone interested in using the design of experiments in industrial settings." —Christopher J. Nachtsheim, Frank A Donaldson Chair in Operations Management, Carlson School of Management, University of Minnesota This book demonstrates the utility of the computer-aided optimal design approach using real industrial examples. These examples address questions such as the following: How can I do screening inexpensively if I have dozens of factors to investigate? What can I do if I have day-to-day variability and I can only perform 3 runs a day? How can I do RSM cost effectively if I have categorical factors? How can I design and analyze experiments when there is a factor that can only be changed a few times over the study? How can I include both ingredients in a mixture and processing factors in the same study? How can I design an experiment if there are many factor combinations that are impossible to run? How can I make sure that a time trend due to warming up of equipment does not affect the conclusions from a study? How can I take into account batch information in when designing experiments involving multiple batches? How can I add runs to a botched experiment to resolve ambiguities? While answering these questions the book also shows how to evaluate and compare designs. This allows researchers to make sensible trade-offs between the cost of experimentation and the amount of information they obtain.

Sequential Experimentation in Clinical Trials

Sequential Experimentation in Clinical Trials
Author: Jay Bartroff
Publisher: Springer Science & Business Media
Total Pages: 250
Release: 2012-12-12
Genre: Medical
ISBN: 1461461146

Sequential Experimentation in Clinical Trials: Design and Analysis is developed from decades of work in research groups, statistical pedagogy, and workshop participation. Different parts of the book can be used for short courses on clinical trials, translational medical research, and sequential experimentation. The authors have successfully used the book to teach innovative clinical trial designs and statistical methods for Statistics Ph.D. students at Stanford University. There are additional online supplements for the book that include chapter-specific exercises and information. Sequential Experimentation in Clinical Trials: Design and Analysis covers the much broader subject of sequential experimentation that includes group sequential and adaptive designs of Phase II and III clinical trials, which have attracted much attention in the past three decades. In particular, the broad scope of design and analysis problems in sequential experimentation clearly requires a wide range of statistical methods and models from nonlinear regression analysis, experimental design, dynamic programming, survival analysis, resampling, and likelihood and Bayesian inference. The background material in these building blocks is summarized in Chapter 2 and Chapter 3 and certain sections in Chapter 6 and Chapter 7. Besides group sequential tests and adaptive designs, the book also introduces sequential change-point detection methods in Chapter 5 in connection with pharmacovigilance and public health surveillance. Together with dynamic programming and approximate dynamic programming in Chapter 3, the book therefore covers all basic topics for a graduate course in sequential analysis designs.

Optimal Design for Nonlinear Response Models

Optimal Design for Nonlinear Response Models
Author: Valerii V. Fedorov
Publisher: CRC Press
Total Pages: 402
Release: 2013-07-15
Genre: Mathematics
ISBN: 1439821526

Optimal Design for Nonlinear Response Models discusses the theory and applications of model-based experimental design with a strong emphasis on biopharmaceutical studies. The book draws on the authors' many years of experience in academia and the pharmaceutical industry. While the focus is on nonlinear models, the book begins with an explanation of