This is the second volume in the series of proceedings from the International Workshop on Life Science Grid. It represents the few, if not the only, dedicated proceedings volumes that gathers together the presentations of leaders in the emerging sub-discipline of grid computing for the life sciences. The volume covers the latest developments, trends and trajectories in life science grid computing from top names in bioinformatics and computational biology: A Konagaya; J C Wooley of the National Science Foundation (NSF) and DoE thought leader in supercomputing and life science computing, and one of the key people in the NSF CIBIO initiative; P Arzberger of PRAGMA fame; and R Sinnott of UK e-Science. Sample Chapter(s). Chapter 1: The Grid as a ba for Biomedical Knowledge Creation (155 KB). Contents: The Grid as a OC BaOCO for Biomedical Knowledge Creation (A Konagaya); Cyberinfrastructure for the Biological Sciences (CIBIO) (J C Wooley); Controlling the Chaos: Developing Post-Genomic Grid Infrastructures (R Sinnott & M Bayer); A Framework for Biological Analysis on the Grid (T Okumura et al.); An Architectural Design of Open Genome Services (R Umetsu et al.); Proteome Analysis Using iGAP in Gfarm (W W Li et al.); Large-Scale Simulation and Prediction of HLA-Epitope Complex Structures (A E H Png et al.); Process Integration for Bio-Manufacturing Grid (Z Q Shen et al.); and other papers. Readership: Practitioners of grid computing as applied to the life sciences, life scientists and biologists working on large computational solutions that require grid computing."