Rna Technologies And Their Applications
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| Author | : Volker A. Erdmann |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 460 |
| Release | : 2010-09-02 |
| Genre | : Medical |
| ISBN | : 3642121683 |
RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 354 |
| Release | : 2012-09-13 |
| Genre | : Science |
| ISBN | : 0309224187 |
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
| Author | : R. K. Gaur |
| Publisher | : CRC Press |
| Total Pages | : 388 |
| Release | : 2016-04-19 |
| Genre | : Science |
| ISBN | : 1439873259 |
RNAi technology is used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. Introducing new technology in the study of RNA
| Author | : Kamel A Abd-Elsalam |
| Publisher | : Elsevier |
| Total Pages | : 842 |
| Release | : 2021-02-27 |
| Genre | : Technology & Engineering |
| ISBN | : 0128219114 |
Plants are vulnerable to pathogens including fungi, bacteria, and viruses, which cause critical problems and deficits. Crop protection by plant breeding delivers a promising solution with no obvious effect on human health or the local ecosystem. Crop improvement has been the most powerful approach for producing unique crop cultivars since domestication occurred, making possible the main innovations in feeding the globe and community development. Genome editing is one of the genetic devices that can be implemented, and disease resistance is frequently cited as the most encouraging application of CRISPR/Cas9 technology in agriculture. Nanobiotechnology has harnessed the power of genome editing to develop agricultural crops. Nanosized DNA or RNA nanotechnology approaches could contribute to raising the stability and performance of CRISPR guide RNAs. This book brings together the latest research in these areas. CRISPR and RNAi Systems: Nanobiotechnology Approaches to Plant Breeding and Protection presents a complete understanding of the RNAi and CRISPR/Cas9 techniques for controlling mycotoxins, fighting plant nematodes, and detecting plant pathogens. CRISPR/Cas genome editing enables efficient targeted modification in most crops, thus promising to accelerate crop improvement. CRISPR/Cas9 can be used for management of plant insects, and various plant pathogens. The book is an important reference source for both plant scientists and environmental scientists who want to understand how nano biotechnologically based approaches are being used to create more efficient plant protection and plant breeding systems. - Shows how nanotechnology is being used as the basis for new solutions for more efficient plant breeding and plant protection - Outlines the major techniques and applications of both CRISPR and RNAi technologies - Assesses the major challenges of escalating these technologies on a mass scale
| Author | : Krishnarao Appasani |
| Publisher | : Cambridge University Press |
| Total Pages | : 564 |
| Release | : 2005-01-17 |
| Genre | : Science |
| ISBN | : 9781139442657 |
RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these genes. In the postgenomic era, the elucidation of the physiological function of genes has become the rate-limiting step in the quest to develop 'gene-based drugs' and RNAi could potentially play a pivotal role in the validation of such novel drugs. In this overview, the basic concepts and applications of RNAi biology are discussed. Leading experts from both academia and industry have contributed to this invaluable reference. The volume is forwarded by Andrew Fire, one of the winners of the 2006 Nobel Prize for the discovery of RNA Interference.
| Author | : Patrick O’Donoghue |
| Publisher | : MDPI |
| Total Pages | : 188 |
| Release | : 2019-11-19 |
| Genre | : Science |
| ISBN | : 3039217348 |
Dear Colleagues, Synthetic biology is a broad and emerging discipline that capitalizes on recent advances in molecular biology, genetics, protein and RNA engineering and omics technologies. These technologies have transformed our ability to reveal the biology of the cell and the molecular basis of disease. This Special Issue on “Synthetic RNA and DNA Programming” features original research articles and reviews, highlighting novel aspects of basic molecular biology and the molecular mechanisms of disease that were uncovered by the application and development of novel synthetic biology-driven approaches.
| Author | : Kazuwa Nakao |
| Publisher | : Springer |
| Total Pages | : 330 |
| Release | : 2015-10-13 |
| Genre | : Science |
| ISBN | : 4431556516 |
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
| Author | : National Research Council |
| Publisher | : National Academies |
| Total Pages | : 471 |
| Release | : 1989-01-01 |
| Genre | : Science |
| ISBN | : 0309039274 |
Biology has entered an era in which interdisciplinary cooperation is at an all-time high, practical applications follow basic discoveries more quickly than ever before, and new technologiesâ€"recombinant DNA, scanning tunneling microscopes, and moreâ€"are revolutionizing the way science is conducted. The potential for scientific breakthroughs with significant implications for society has never been greater. Opportunities in Biology reports on the state of the new biology, taking a detailed look at the disciplines of biology; examining the advances made in medicine, agriculture, and other fields; and pointing out promising research opportunities. Authored by an expert panel representing a variety of viewpoints, this volume also offers recommendations on how to meet the infrastructure needsâ€"for funding, effective information systems, and other supportâ€"of future biology research. Exploring what has been accomplished and what is on the horizon, Opportunities in Biology is an indispensable resource for students, teachers, and researchers in all subdisciplines of biology as well as for research administrators and those in funding agencies.
| Author | : Akio Makishima |
| Publisher | : Elsevier |
| Total Pages | : 270 |
| Release | : 2017-01-27 |
| Genre | : Science |
| ISBN | : 0128120592 |
Origins of the Earth, Moon, and Life: An Interdisciplinary Approach presents state-of-the-art knowledge that is based on theories, experiments, observations, calculations, and analytical data from five astro-sciences, astronomy, astrobiology, astrogeology, astrophysics, and cosmochemistry. Beginning with the origin of elements, and moving on to cover the formation of the early Solar System, the giant impact model of the Earth and Moon, the oldest records of life, and the possibility of life on other planets in the Solar System, this interdisciplinary reference provides a complex understanding of the planets and the formation of life. Synthesizing concepts from all branches of astro-sciences into one, the book is a valuable reference for researchers in astrogeology, astrophysics, cosmochemistry, astrobiology, astronomy, and other space science fields, helping users better understand the intersection of these sciences. - Includes extensive figures and tables to enhance key concepts - Uses callout boxes throughout to provide context and deeper explanations - Presents up-to-date information on the universe, stars, planets, moons, and life in the solar system - Combines knowledge from the fields of astrogeology, astrophysics, cosmochemistry, astrobiology, and astronomy, helping readers understand the origins of the Earth, the moon, and life in our solar system
| Author | : Mouldy Sioud |
| Publisher | : Humana Press |
| Total Pages | : 527 |
| Release | : 2011-03-04 |
| Genre | : Science |
| ISBN | : 9781607616641 |
Central to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has proven to be key target for therapeutics as well as a tool for therapy. In RNA Therapeutics: Function, Design, and Delivery, expert contributors from a broad spectrum of scientific backgrounds highlight the roles that messenger RNAs and small RNAs can play in biology and medicine. While covering the five major RNA-based drugs, namely the use of ribozymes to cleave and/or correct mRNA transcript, the use of siRNA for targeted silencing of gene transcripts, the use of aptamers, like short RNA molecules, for neutralizing the protein functions, the use mRNA-transfected DCs to activate immune system against tumor cells, as well as the use of RNA to reprogram T and/or DC cell function, this extensive volume brings together the fields of coding (mRNA) and non-coding RNA such as ribozymes, RNAse P, siRNAs, and miRNAs into one convenient source. Written in the highly successful Methods in Molecular BiologyTM series format, the cutting-edge protocol chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and practical tips on troubleshooting and avoiding known pitfalls. Also, the book contains several excellent reviews for teaching purposes. Authoritative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of vital new RNA-based therapeutics.
