Regulation of Diethylstilbestrol (DES)
Author | : United States. Congress. House. Committee on Government Operations. Intergovernmental Relations Subcommittee |
Publisher | : |
Total Pages | : 256 |
Release | : 1972 |
Genre | : Diethylstilbestrol |
ISBN | : |
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Author | : United States. Congress. House. Committee on Government Operations. Intergovernmental Relations Subcommittee |
Publisher | : |
Total Pages | : 256 |
Release | : 1972 |
Genre | : Diethylstilbestrol |
ISBN | : |
Author | : Nancy Langston |
Publisher | : Yale University Press |
Total Pages | : 253 |
Release | : 2010-03-02 |
Genre | : Science |
ISBN | : 0300162995 |
In 1941 the Food and Drug Administration approved the use of diethylstilbestrol (DES), the first synthetic chemical to be marketed as an estrogen and one of the first to be identified as a hormone disruptor—a chemical that mimics hormones. Although researchers knew that DES caused cancer and disrupted sexual development, doctors prescribed it for millions of women, initially for menopause and then for miscarriage, while farmers gave cattle the hormone to promote rapid weight gain. Its residues, and those of other chemicals, in the American food supply are changing the internal ecosystems of human, livestock, and wildlife bodies in increasingly troubling ways. In this gripping exploration, Nancy Langston shows how these chemicals have penetrated into every aspect of our bodies and ecosystems, yet the U.S. government has largely failed to regulate them and has skillfully manipulated scientific uncertainty to delay regulation. Personally affected by endocrine disruptors, Langston argues that the FDA needs to institute proper regulation of these commonly produced synthetic chemicals.
Author | : United States. Congress. House. Committee on Government Operations. Intergovernmental Relations Subcommittee |
Publisher | : |
Total Pages | : 464 |
Release | : 1972 |
Genre | : Diethylstilbestrol |
ISBN | : |
Author | : Ruben Vardanyan |
Publisher | : Elsevier |
Total Pages | : 635 |
Release | : 2006-03-10 |
Genre | : Medical |
ISBN | : 008046212X |
Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO's Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types* Includes synonyms* Includes over 2300 references
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 453 |
Release | : 2000-02-03 |
Genre | : Science |
ISBN | : 0309064198 |
Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.
Author | : Faysal A. Yafi |
Publisher | : Academic Press |
Total Pages | : 446 |
Release | : 2019-08-21 |
Genre | : Science |
ISBN | : 0128169400 |
Effects of Lifestyle on Men's Health provides an evidence-based review of the effects of modifiable risk factors such as sleep, diet, stress and exercise on various elements of men's health, notably sexual function, urinary function and cancer prevention and detection. Content highlights the most up-to-date basic and clinical information available, along with future research directions. Each chapter provides an easy to reference bullet point style summary to highlight the salient take-home messages from each section. Researchers and clinicians alike can use this book as a reference point for all matters related to lifestyle and men's health. - Offers an evidence-based review of the associations between modifiable risk factors (diet, lifestyle, sleep, environment and exercise) and men's health - Delivers examples of how changes to risk factors improve overall health - Provides insight into what the future of men's health holds in terms of basic and clinical research
Author | : Juliusz Ashot Kozak |
Publisher | : CRC Press |
Total Pages | : 343 |
Release | : 2017-07-14 |
Genre | : Science |
ISBN | : 149875273X |
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Author | : Robert Meyers |
Publisher | : |
Total Pages | : 264 |
Release | : 1983 |
Genre | : Health & Fitness |
ISBN | : |
Author | : Rebecca Fry |
Publisher | : Academic Press |
Total Pages | : 285 |
Release | : 2015-06-11 |
Genre | : Medical |
ISBN | : 0128015683 |
Systems Biology in Toxicology and Environmental Health uses a systems biological perspective to detail the most recent findings that link environmental exposures to human disease, providing an overview of molecular pathways that are essential for cellular survival after exposure to environmental toxicants, recent findings on gene-environment interactions influencing environmental agent-induced diseases, and the development of computational methods to predict susceptibility to environmental agents. Introductory chapters on molecular and cellular biology, toxicology and computational biology are included as well as an assessment of systems-based tools used to evaluate environmental health risks. Further topics include research on environmental toxicants relevant to human health and disease, various high-throughput technologies and computational methods, along with descriptions of the biological pathways associated with disease and the developmental origins of disease as they relate to environmental contaminants. Systems Biology in Toxicology and Environmental Health is an essential reference for undergraduate students, graduate students, and researchers looking for an introduction in the use of systems biology approaches to assess environmental exposures and their impacts on human health. - Provides the first reference of its kind, demonstrating the application of systems biology in environmental health and toxicology - Includes introductions to the diverse fields of molecular and cellular biology, toxicology, and computational biology - Presents a foundation that helps users understand the connections between the environment and health effects, and the biological mechanisms that link them
Author | : Alberto Mantovani |
Publisher | : Royal Society of Chemistry |
Total Pages | : 539 |
Release | : 2020-12-08 |
Genre | : Science |
ISBN | : 1839160837 |
Insight into the role of hormones, particularly estrogen and testosterone, in health and disease etiology – including interactions with other hormone pathways – has dramatically changed. Estrogen and androgen receptors, with their polymorphisms, are key molecules in all tissues and are involved in a number of homeostatic mechanisms but also pathological processes including carcinogenesis and the development of metabolic and neurological disorders such as diabetes and Alzheimer’s disease. Endocrine disrupting chemicals (EDCs) can interfere with the endocrine (hormone) systems at certain dosages and play a key role in the pathology of disease. Most known EDCs are manmade and are therefore an increasing concern given the number commonly found in household products and the environment. This book will cover the mechanisms of EDC pathology across the spectrum of disease, as well as risk assessment and government and legal regulation to provide a holistic view of the current issues and cutting-edge research in the topic. With contributions from global leaders in the field, this book will be an ideal reference for toxicologists, endocrinologists and researchers interested in developmental biology, regulatory toxicology and the interface between environment and human health.