Recent Advances In The Study Of The Host Fungus Interaction
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Author | : Attila Gacser |
Publisher | : Frontiers Media SA |
Total Pages | : 150 |
Release | : 2017-01-13 |
Genre | : |
ISBN | : 2889450627 |
Fungal infections represent nowadays a significant burden on the healthcare system of most of the countries, and are among the infections with the highest mortality rates. This has fostered the study of the interaction of these organisms with the human host. The outer most layer of a fungal cell is the cell wall, and together with the secreted components into the extracellular compartment, are the first lines of contact with the host cells. This interaction is critical for tissue adhesion, colonization and damage. In addition, these fungal extracellular components will define the outcome of the interaction with the host immune cells, leading either to the establishment of a protective antifungal immune response or to an immune-evasive mechanism by the fungal cell. On the other hand, our immune system has effectively evolved to deal with fungal pathogens, developing strategies for cell eradication, burden control, or antigen presentation from the innate branch to the adaptive immune response. Here, we provide a series of comprehensive review papers dealing with both aspect of the interaction fungus-immune cells: the role of virulence factors and cell wall components during such interaction, and the recent advances in the study of cellular receptors in the establishment of a protective anti-fungal immune response.
Author | : |
Publisher | : |
Total Pages | : 0 |
Release | : 2017 |
Genre | : |
ISBN | : |
Fungal infections represent nowadays a significant burden on the healthcare system of most of the countries, and are among the infections with the highest mortality rates. This has fostered the study of the interaction of these organisms with the human host. The outer most layer of a fungal cell is the cell wall, and together with the secreted components into the extracellular compartment, are the first lines of contact with the host cells. This interaction is critical for tissue adhesion, colonization and damage. In addition, these fungal extracellular components will define the outcome of the interaction with the host immune cells, leading either to the establishment of a protective antifungal immune response or to an immune-evasive mechanism by the fungal cell. On the other hand, our immune system has effectively evolved to deal with fungal pathogens, developing strategies for cell eradication, burden control, or antigen presentation from the innate branch to the adaptive immune response. Here, we provide a series of comprehensive review papers dealing with both aspect of the interaction fungus-immune cells: the role of virulence factors and cell wall components during such interaction, and the recent advances in the study of cellular receptors in the establishment of a protective anti-fungal immune response.
Author | : Eleftherios Mylonakis |
Publisher | : Springer Science & Business Media |
Total Pages | : 135 |
Release | : 2011-12-01 |
Genre | : Science |
ISBN | : 1441956387 |
Most studies of bacterial or fungal infectious diseases focus separately on the pathogenic microbe, the host response, or the characterization of therapeutic compounds. Compartmentalization of pathogenesis-related research into an analysis of the “pathogen”, the “host,” or the “antimicrobial compound” has largely been dictated by the lack of model systems in which all of these approaches can be used simultaneously, as well as by the traditional view that microbiology, immunology, and chemical biology and pharmacology are separate disciplines. An increasing number of workers from different fields have turned to insects, fish, worms and other model hosts as facile, ethically expedient, relatively simple, and inexpensive hosts to model a variety of human infectious diseases and to study host responses and innate immunity. Because many of these hosts are genetically tractable, they can be used in conjunction with an appropriate pathogen to facilitate the discovery of novel features of the host innate immune response. This book provides a series of reports from the 1st International Conference on Model Hosts. This first of its kind meeting focused on invertebrate, vertebrate and amoeboid systems used for the study of host-pathogen interactions, virulence and immunity, as well as on the relevance of these pathogenesis systems and mammalian models. Importantly, a common, fundamental set of molecular mechanisms is employed by a significant number of microbial pathogens against a widely divergent array of metazoan hosts. Moreover, the evolutionarily conserved immune responses of these model hosts have contributed important insights to our understanding of the innate immune response of mammals. This book provides a series of reports from the 1st International Conference on Model Hosts. This first of its kind meeting focused on invertebrate, vertebrate and amoeboid systems used for the study of host-pathogen interactions, virulence and immunity, as well as on the relevance of these pathogenesis systems and mammalian models. Importantly, a common, fundamental set of molecular mechanisms is employed by a significant number of microbial pathogens against a widely divergent array of metazoan hosts. Moreover, the evolutionarily conserved immune responses of these model hosts have contributed important insights to our understanding of the innate immune response of mammals.
Author | : Alexandra C. Brand |
Publisher | : Humana Press |
Total Pages | : 597 |
Release | : 2016-08-23 |
Genre | : Science |
ISBN | : 9781493959044 |
Microbiologists, medical mycologists, immunologists, and biochemists are increasingly working together to focus on the processes involved in the progression and treatment of fungal disease. Host-Fungus Interactions: Methods and Protocols is designed for research scientists who are involved in this work and interested in undertaking new or comparative studies of interactions between the mammalian host and clinically important fungal pathogens. Aiming to combine approaches for reverse genetics in pathogenic fungi with methods for their application in in vitro and in vivo models of disease, the book includes methods for the culture and genetic manipulation of the primary fungal pathogens and the opportunistic pathogens, as well as methods for investigating host-fungus interactions in model systems. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Host-Fungus Interactions: Methods and Protocols describes available molecular methods and fungal infection models in great detail in order to encourage researchers to try new approaches to investigating host-fungus interactions with added levels of confidence.
Author | : Marcela C. Pagano |
Publisher | : Springer |
Total Pages | : 149 |
Release | : 2016-04-26 |
Genre | : Science |
ISBN | : 3319243551 |
Recent Advances on Mycorrhizal Fungi integrates work done by pre-eminent scientists, academics, and researchers dedicated to the study of mycorrhizas in laboratories around the world. The main aim of this book is to compile the information related to mycorrhizas advancement and their applications. First, an overview of the recent advances in mycorrhizal fungi is fully examined. Then, researchers from different countries address issues related to semiarid, xeric, and agro-ecosystems. A greater understanding of the ecology of this type of fungi will underpin efforts to provide new strategies for agriculture production systems and environmental solutions. Finally, relevant topics such as plant stress and ecological succession with regard to mycorrhizal symbioses are discussed. This book will be useful to those who work with mycorrhizas and important for academic and research teams, as well as to teachers, students, professionals and farmers. This information will be a key foundation to decision-makers worldwide and also for conservationists and ecologists.
Author | : Elaine Bignell |
Publisher | : Humana |
Total Pages | : 242 |
Release | : 2021-02-13 |
Genre | : Science |
ISBN | : 9781071611814 |
This volume provides readers with essential protocols for dissecting the host-fungus interaction, and engages researchers in study of mammalian disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Host-Fungal Interactions: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Author | : Joseph Heitman |
Publisher | : John Wiley & Sons |
Total Pages | : 1136 |
Release | : 2020-07-10 |
Genre | : Medical |
ISBN | : 1555819583 |
Fungi research and knowledge grew rapidly following recent advances in genetics and genomics. This book synthesizes new knowledge with existing information to stimulate new scientific questions and propel fungal scientists on to the next stages of research. This book is a comprehensive guide on fungi, environmental sensing, genetics, genomics, interactions with microbes, plants, insects, and humans, technological applications, and natural product development.
Author | : Vishukumar Aimanianda |
Publisher | : |
Total Pages | : 0 |
Release | : 2020 |
Genre | : |
ISBN | : |
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author | : Hermann H. Prell |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2001-03-27 |
Genre | : Science |
ISBN | : 9783540667278 |
Research on the interactions of plants and phytopathogenic fungi has become one of the most interesting and rapidly moving fields in the plant sciences, the findings of which have contributed tremendously to the development of new strategies of plant protection. This book offers insight into the state of present knowledge. Special emphasis is placed on recognition phenomena between plants and fungi, parasitization strategies employed by the phytopathogenic fungi, the action of phytotoxins, the compatibility of pathogens with host plants and the basic resistance of non-host plants as well as cultivar-specific resistance of host plants. Special attention is paid to the gene-for-gene hypothesis for the determination of race-specific resistance, its molecular models and to the nature of race non-specific resistance as well as the population dynamics of plants and the evolution of their basic resistance.
Author | : Joginder Singh |
Publisher | : Elsevier |
Total Pages | : 328 |
Release | : 2020-06-25 |
Genre | : Technology & Engineering |
ISBN | : 0128226234 |
New and Future Developments in Microbial Biotechnology and Bioengineering: Recent Advances in Application of Fungi and Fungal Metabolites: Biotechnological Interventions and Futuristic Approaches is an invaluable resource for researchers planning to work in applied biotechnological interventions and futuristic approaches to fungi and fungal metabolite utilization. Special emphasis is placed on new research relating to fungal-based recombinant DNA technology and genomics analysis which place yeasts and filamentous fungi at the forefront of various contemporary commercial applications. Written in an easy-to-follow language by active researchers, the book presents cutting-edge fungal biotechnological applications in a manner that is accessible to all. Introduces recent biotechnological interventions and futuristic approaches to fungi and their metabolites Elaborates on perspectives and diverse applications of harnessing the potential of fungi and fungal metabolites in biotechnology Describes traditional uses and modern practices of accessing the potential of fungi and their metabolites in solving future needs