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| Author | : Carl D. B. Banner |
| Publisher | : |
| Total Pages | : 280 |
| Release | : 1992 |
| Genre | : Medical |
| ISBN | : |
These 22 papers cover protein trafficking, lysosomal proteolysis, calpains, serpins, processing of cytoskeletal proteins, and complex proteolytic cascades of the circulatory system.
| Author | : Jos Tournoy |
| Publisher | : Leuven University Press |
| Total Pages | : 124 |
| Release | : 2006 |
| Genre | : Medical |
| ISBN | : 9789058675262 |
| Author | : Carl D. B. Banner |
| Publisher | : |
| Total Pages | : 282 |
| Release | : 1992 |
| Genre | : Medical |
| ISBN | : |
These 22 papers cover protein trafficking, lysosomal proteolysis, calpains, serpins, processing of cytoskeletal proteins, and complex proteolytic cascades of the circulatory system.
| Author | : Matthew Louis Hemming |
| Publisher | : |
| Total Pages | : 558 |
| Release | : 2007 |
| Genre | : |
| ISBN | : |
Accumulation and deposition of the amyloid beta-protein (A[beta]) is an invariant feature of Alzheimer's disease (AD). Biochemical, cell biological, animal modeling, genetic, and emerging clinical data all suggest that A[beta] is an upstream initiator of the disease process and its neuropathology. Decreasing brain A[beta] is an emerging therapeutic approach for AD, and currently efforts are being made to block A[beta] production or enhance its clearance through vaccination. A less well understood mechanism of A[beta] clearance is enzymatic degradation by proteases within the brain. The purpose of this thesis is to describe pathways of A[beta] catabolism that may shed light on disease pathogenesis. Further, such insight may prove useful for assessing disease risk as well as offering preventative and therapeutic measures against the disease. I first present evidence that an enzyme genetically associated with AD, the angiotensin-converting enzyme (ACE), is an A[beta]-degrading protease. I determine that ACE is expressed within the brain, and that cellular overexpression of ACE promotes the degradation of A[beta].
| Author | : Uday Kishore |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 642 |
| Release | : 2013-05-15 |
| Genre | : Medical |
| ISBN | : 9535110888 |
This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.
| Author | : Khalid Iqbal |
| Publisher | : John Wiley & Sons |
| Total Pages | : 888 |
| Release | : 2003-01-24 |
| Genre | : Medical |
| ISBN | : 0470851740 |
Alzheimer's Disease is an ever present problem affecting millions of people around the world and, as people's average lifespan lengthens, its prevalence is set to increase. A global effort is needed to combat the disease, including research to investigate the causes, development of effective treatments and, ultimately, prevention of the disease. Published every two years, these timely books discuss the very latest research. This new volume provides a unique source of reference to the important work being done in this field, it gives academics and clinicians an opportunity to learn about cutting edge developments and covers all aspects of Alzheimer's Disease, including diagnosis, clinical course, epidemiological course and therapeutics and disease mechanisms. Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics will provide essential information for basic and clinical researchers in Alzheimer's Disease and other dementias as well as for those who care for patients.
| Author | : Robert A. Nichols |
| Publisher | : Frontiers Media SA |
| Total Pages | : 209 |
| Release | : 2022-04-06 |
| Genre | : Science |
| ISBN | : 2889744582 |
| Author | : Nancy Y. Ip |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 326 |
| Release | : 2009-02-28 |
| Genre | : Medical |
| ISBN | : 0387788875 |
Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.
