This first International Symposium on Agricultural Innovation for Family Farmers called for inclusive research and education systems to facilitate innovation; robust bridging institutions; support to family farmers; and integrated policies and increased investments to create an enabling environment for innovation and scaling up. Innovation is the process whereby individuals or organizations bring new or existing products, processes or ways of organization into use for the first time in a specific context. Innovation in agriculture cuts across all dimensions of the production cycle along the entire value chain - from crop, forestry, fishery or livestock production to the management of inputs and resources to market access. The symposium provided inspiration for innovation actors and decision makers to unlock the potential of innovation to drive socio-economic growth, ensure food and nutrition security, alleviate poverty, improve resilience to changing environments and thereby achieve the Sustainable Development Goals.