This book constitutes the refereed proceedings of the 14th International Symposium on Algorithms and Computation, ISAAC 2003, held in Kyoto, Japan, in December 2003. The 73 revised full papers presented were carefully reviewed and selected from 207 submissions. The papers are organized in topical sections on computational geometry, graph and combinatorial algorithms, computational complexity, quantum computing, combinatorial optimization, scheduling, computational biology, distributed and parallel algorithms, data structures, combinatorial and network optimization, computational complexity and cryptography, game theory and randomized algorithms, and algebraic and arithmetic computation.