Substance Use and Addiction Research: Methodology, Mechanisms, and Therapeutics is an up-to-date, comprehensive, practical book on research methodologies for substance use and addiction that is intended for researchers and consumers of research information at all levels. The book is divided into four major sections, including an Introduction, Research Methodology for clinical trials, animal research and retrospective studies, Mechanisms of Use and Addiction, and Investigative Therapeutics: Designing and Measuring Outcomes. It serves a source for addressing all aspects of research design, methods and analysis within the context of the field of opioids, alcohol and other substances. The book covers what is known in the field of quantitative and qualitative research methods, provides future directions, and introduces new models for investigation. It is organized around a translational science framework, with the contents addressing substance use/addiction research in the context of epidemiology, etiology, intervention efficacy and effectiveness, and implementation of evidence-informed interventions. - Presents a practical, easy to read text designed to appeal to both experienced and beginner researchers in the field of substance abuse/addiction science - Provides a concise, well-organized handbook that is a complete guide to methodologies in conducting substance abuse/addiction research - Contains contributions from leading academic institutions - Includes ample diagrams, tables and figures to help organize the information for easy reference, along with a list and explanation of existing useful measurement tools, websites, statistical methods and other resources