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| Author | : Joel Bernstein |
| Publisher | : |
| Total Pages | : 602 |
| Release | : 2020 |
| Genre | : Science |
| ISBN | : 0199655448 |
Polymorphism in chemistry is the existence of multiple crystal structures for one substance. The properties of a substance are determined by its composition and by its structure. This book summarizes and brings up to date the current knowledge and understading of polymorphism of molecular crystals.
| Author | : Joel Bernstein |
| Publisher | : Oxford University Press |
| Total Pages | : 429 |
| Release | : 2002 |
| Genre | : Business & Economics |
| ISBN | : 0198506058 |
Polymorphism - the multiplicity of structures or forms - is a term that is used in many disciplines. In chemistry it refers to the existence of more than one crystal structure for a particular chemical substance. The properties of a substance are determined by its composition and by its structure. In the last two decades, there has been a sharp rise in the interest in polymorphic systems, as an intrinsically interesting phenomenon and as an increasingly important component in the development and marketing of a variety of materials based on organic molecules (e.g. pharmaceuticals, dyes and pigments, explosives, etc.). This book summarizes and brings up to date the current knowledge and understanding of polymorphism of molecular crystals, and concentrates it in one comprehensive source. The book will be an invaluable reference for students, researchers, and professionals in the field.
| Author | : Rolf Hilfiker |
| Publisher | : John Wiley & Sons |
| Total Pages | : 512 |
| Release | : 2019-04-29 |
| Genre | : Science |
| ISBN | : 3527340408 |
"Polymorphism in the Pharmaceutical Industry - Solid Form and Drug Development" highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus on quality by design (QbD) concepts. It covers all important issues by way of case studies, ranging from properties and crystallization, via thermodynamics, analytics and theoretical modelling right up to patent issues. As such, the book underscores the importance of solid-state chemistry within chemical and pharmaceutical development. It emphasizes why solid-state issues are important, the approaches needed to avoid problems and the opportunities offered by solid-state properties. The authors include true polymorphs as well as solvates and hydrates, while providing information on physicochemical properties, crystallization thermodynamics, quantum-mechanical modelling, and up-scaling. Important analytical tools to characterize solid-state forms and to quantify mixtures are summarized, and case studies on solid-state development processes in industry are also provided. Written by acknowledged experts in the field, this is a high-quality reference for researchers, project managers and quality assurance managers in pharmaceutical, agrochemical and fine chemical companies as well as for academics and newcomers to organic solid-state chemistry.
| Author | : Harry G. Brittain |
| Publisher | : CRC Press |
| Total Pages | : 656 |
| Release | : 2018-11-12 |
| Genre | : Medical |
| ISBN | : 1420073222 |
Using clear and practical examples, Polymorphism of Pharmaceutical Solids, Second Edition presents a comprehensive examination of polymorphic behavior in pharmaceutical development that is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This edition focuses on pharmaceutical aspects of polymorphism a
| Author | : Shayne Cox Gad |
| Publisher | : John Wiley & Sons |
| Total Pages | : 1352 |
| Release | : 2008-03-21 |
| Genre | : Medical |
| ISBN | : 0470249021 |
A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * Modeling and informatics in drug design * Bioanalytical chemistry * Absorption of drugs after oral administration * Transporter interactions in the ADME pathway of drugs * Metabolism kinetics * Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.
| Author | : Douglas L. Dorset |
| Publisher | : OUP Oxford |
| Total Pages | : 244 |
| Release | : 2004-12-09 |
| Genre | : Science |
| ISBN | : 0191523801 |
By considering the solid state packing of linear chain wax components, this book aims at understanding three things: firstly, which modifications of molecular components are allowed for maintaining stable solid solutions; secondly, what happens when stability conditions are traversed and fractionation begins and thirdly, the structure of fractionated arrays. The co-compatibility of molecular ingredients is considered in terms of their shapes and relative sizes, following an approach originally proposed by Kitaigorodskii. As demonstrated profusely by the crystal structures of pure component types (e. g. alkanes, fatty alcohols, fatty acids, long chain esters, cholesteryl esters) and insertion of functional groups (e. g. chain branches, unsaturation, heteroatoms), characteristic molecular packing arrays provide important geometric information for understanding the co-packing of different molecules in mixtures. Single crystal and spectroscopic data from polydisperse arrays can then be evaluated to arrive at plausible structures of solid solutions and fractionated systems. The resultant structures are not only relevant to the understanding of so-called waxes but also include certain classes of polymers. The ramifications of this work extend into any solid state array of polymethylene chains, including lipid foodstuffs.
| Author | : Barta |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 0 |
| Release | : 2023-04-27 |
| Genre | : Political Science |
| ISBN | : 9780198877356 |
Most people are familiar with the fact that diamond and graphite are both composed only of carbon; yet they have very different properties which result from the very different structures of the two solids - they are polymorphs of carbon. Understanding the relationship between the structures and the properties of materials is of fundamental importance in developing and producing new materials with improved or new properties. The existence of polymorphic systems allows the direct study of the connection between structures and properties. This book provides grounding on the fundamental structural and energetic basis for polymorphism, the preparation and characterization of polymorphic substances and its importance in the specific areas of pharmaceuticals, pigments and high energy (explosive) materials. The closing chapter describes the intellectual property implications and some of the precedent patent litigations in which polymorphism has played a central role. The book contains over 2500 references to provide a ready entry into the relevant literature.
| Author | : Jonathan W. Steed |
| Publisher | : John Wiley & Sons |
| Total Pages | : 1220 |
| Release | : 2022-01-10 |
| Genre | : Science |
| ISBN | : 1119582490 |
A one-stop, comprehensive, and thoroughly updated resource for students, professors, and researchers alike Thoroughly revised and updated, the Third Edition of Supramolecular Chemistry delivers a comprehensive and integrated approach to this rapidly evolving and quickly expanding field. Distinguished professors and authors Jonathan Steed and Jerry Atwood provide readers with a broad and exhaustive resource that assumes little in the way of prior knowledge of supramolecular chemistry. Extensive new content on cutting edge research throughout the field including molecular machines and the mechanical bond, mechanochemistry, halogen bonding, and crystal nucleation accompanies full-color imagery and study problems designed to help students understand and apply the principles introduced within the book. Additional material is provided in the supplementary online resources, including solutions to the student exercises and PowerPoint slides of the figures in the book. Supramolecular Chemistry, Third Edition also includes: The latest research and developments reported over the last decade A unique “key references” system that highlights crucial reviews and primary literature A description of key experimental techniques included in accessible “boxes” for the non-expert Exercises and problems for students, complete with online solutions Full-color illustrations and imagery designed to facilitate learning and retention of the key concepts and state-of-the art of the field Perfect for undergraduate and postgraduate students taking courses on supramolecular chemistry, the Third Edition of Supramolecular Chemistry also belongs on the bookshelves of all researchers in this, and any closely related, fields. Academics, in particular postdoctoral students and professors, will benefit significantly from this text.
| Author | : Michael Gruss |
| Publisher | : John Wiley & Sons |
| Total Pages | : 576 |
| Release | : 2021-09-14 |
| Genre | : Science |
| ISBN | : 3527823069 |
Solid State Development and Processing of Pharmaceutical Molecules A guide to the lastest industry principles for optimizing the production of solid state active pharmaceutical ingredients Solid State Development and Processing of Pharmaceutical Molecules is an authoritative guide that covers the entire pharmaceutical value chain. The authors—noted experts on the topic—examine the importance of the solid state form of chemical and biological drugs and review the development, production, quality control, formulation, and stability of medicines. The book explores the most recent trends in the digitization and automation of the pharmaceutical production processes that reflect the need for consistent high quality. It also includes information on relevant regulatory and intellectual property considerations. This resource is aimed at professionals in the pharmaceutical industry and offers an in-depth examination of the commercially relevant issues facing developers, producers and distributors of drug substances. This important book: Provides a guide for the effective development of solid drug forms Compares different characterization methods for solid state APIs Offers a resource for understanding efficient production methods for solid state forms of chemical and biological drugs Includes information on automation, process control, and machine learning as an integral part of the development and production workflows Covers in detail the regulatory and quality control aspects of drug development Written for medicinal chemists, pharmaceutical industry professionals, pharma engineers, solid state chemists, chemical engineers, Solid State Development and Processing of Pharmaceutical Molecules reviews information on the solid state of active pharmaceutical ingredients for their efficient development and production.
| Author | : Juan J. Novoa |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 520 |
| Release | : 2007-12-14 |
| Genre | : Technology & Engineering |
| ISBN | : 1402068239 |
This volume collects the state of the art in molecular materials. It collects the lecture notes of a series of lectures given by some of the best specialists in the field at the 2007 Erice International School of Crystallography, and also a NATO-ASI course. The school first established "where we are" in terms of modeling, design, synthesis and applications of crystalline solids with predefined properties and then defined current and possible futuristic lines of development.
