Polyethylene Glycol Chemistry
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| Author | : J. Milton Harris |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 395 |
| Release | : 2013-11-21 |
| Genre | : Medical |
| ISBN | : 1489907033 |
The idea for this book came from discussions among participants in a symposium on biotechnical applications at the "Pacifichem 89" meeting in Honolulu. It was the majority opinion of this group that a volume dedicated to biotechnical and biomedical applications of PEG chemistry would enhance research and development in this area. Though the book was conceived at the Honolulu meeting, it is not a proceedings of this symposium. Several groups who did not participate in this meeting are repre sented in the book, and the book incorporates much work done after the meeting. The book does not include contributions in all related areas to which PEG chemistry has been applied. Several invited researchers declined to parti.:ipate, and there is not enough space in this single volume to properly cover all submissions. Chapter I-an overview of the topic-discusses in brief applications not given detailed coverage in specifically devoted chapters. The following topics are covered: introduction to and fundamental properties of PEG and derivatives in Chapters 1-3; separations using aqueous polymer two-phase partitioning in Chapters 4-6; PEG-proteins as catalysts in biotechnical applications in Chapters 7 and 8; biomedical applications of PEG-proteins in Chapters 9-13; PEG modified surfaces for a variety of biomedical and biotechnical applications in Chapters 14-20; and synthesis of new PEG derivatives in Chapters 21 and 22.
| Author | : J. Milton Harris |
| Publisher | : |
| Total Pages | : 512 |
| Release | : 1997 |
| Genre | : Science |
| ISBN | : |
This volume provides an interdisciplinary analysis of current biological applications of poly(ethylene glycol) (PEG). It includes a wide array of topics useful to materials scientists, organic chemists, biochemists, and bioengineers interested in drug delivery systems, pharmaceuticals and other biomaterials. The applications discussed include PEG-modified proteins, liposomes, drugs, surfaces of materials, and hydrogels. The volume also includes a review of PEG-oligonucleotides and a concise summary of the toxicology of PEG and its derivatives.
| Author | : Francesco M. Veronese |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 289 |
| Release | : 2009-12-30 |
| Genre | : Medical |
| ISBN | : 3764386797 |
PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.
| Author | : Greg T. Hermanson |
| Publisher | : Academic Press |
| Total Pages | : 1233 |
| Release | : 2010-07-26 |
| Genre | : Science |
| ISBN | : 0080568726 |
Bioconjugate Techniques, 2nd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or cross linking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. A one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab Step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates More than 600 figures that visually describe the complex reactions associated with the synthesis of bioconjugates Includes entirely new chapters on the latest areas in the field of bioconjugation as follows: Microparticles and nanoparticlesSilane coupling agentsDendrimers and dendronsChemoselective ligationQuantum dotsLanthanide chelatesCyanine dyesDiscrete PEG compoundsBuckyballs,fullerenes, and carbon nanotubesMass tags and isotope tagsBioconjugation in the study of protein interactions
| Author | : Danilo D. Lasic |
| Publisher | : CRC Press |
| Total Pages | : 324 |
| Release | : 2018-05-04 |
| Genre | : Medical |
| ISBN | : 1351414011 |
This book examines stealth liposomes from a multidisciplinary approach, which includes theoretical polymer physics, organic synthesis, colloid science, and biology. Discussions include theory, chemistry, biochemistry, pharmacology, preclinical studies in model systems, and medical applications in humans.
| Author | : Floris van Delft |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 477 |
| Release | : 2021-12-22 |
| Genre | : Medical |
| ISBN | : 1839162635 |
Chemical Linkers in Antibody-Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety.
| Author | : National Academies of Sciences, Engineering, and Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 775 |
| Release | : 2018-05-18 |
| Genre | : Medical |
| ISBN | : 030946837X |
Millions of Americans use e-cigarettes. Despite their popularity, little is known about their health effects. Some suggest that e-cigarettes likely confer lower risk compared to combustible tobacco cigarettes, because they do not expose users to toxicants produced through combustion. Proponents of e-cigarette use also tout the potential benefits of e-cigarettes as devices that could help combustible tobacco cigarette smokers to quit and thereby reduce tobacco-related health risks. Others are concerned about the exposure to potentially toxic substances contained in e-cigarette emissions, especially in individuals who have never used tobacco products such as youth and young adults. Given their relatively recent introduction, there has been little time for a scientific body of evidence to develop on the health effects of e-cigarettes. Public Health Consequences of E-Cigarettes reviews and critically assesses the state of the emerging evidence about e-cigarettes and health. This report makes recommendations for the improvement of this research and highlights gaps that are a priority for future research.
| Author | : Harald Mehling |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 316 |
| Release | : 2008-08-15 |
| Genre | : Science |
| ISBN | : 354068557X |
The years 2006 and 2007 mark a dramatic change of peoples view regarding c- mate change and energy consumption. The new IPCC report makes clear that - mankind plays a dominant role on climate change due to CO emissions from en- 2 ergy consumption, and that a significant reduction in CO emissions is necessary 2 within decades. At the same time, the supply of fossil energy sources like coal, oil, and natural gas becomes less reliable. In spring 2008, the oil price rose beyond 100 $/barrel for the first time in history. It is commonly accepted today that we have to reduce the use of fossil fuels to cut down the dependency on the supply countries and to reduce CO emissions. The use of renewable energy sources and 2 increased energy efficiency are the main strategies to achieve this goal. In both strategies, heat and cold storage will play an important role. People use energy in different forms, as heat, as mechanical energy, and as light. With the discovery of fire, humankind was the first time able to supply heat and light when needed. About 2000 years ago, the Romans started to use ceramic tiles to store heat in under floor heating systems. Even when the fire was out, the room stayed warm. Since ancient times, people also know how to cool food with ice as cold storage.
| Author | : Raphael M. Ottenbrite |
| Publisher | : CRC Press |
| Total Pages | : 332 |
| Release | : 2019-04-30 |
| Genre | : Science |
| ISBN | : 9781420010251 |
Polymeric materials are now playing an increasingly important role in pharmaceuticals, as well as in sensing devices, in situ prostheses and probes, and microparticle diagnostic agents. This new volume consists of twenty-two recent research-based reports on the developments in these areas of pharmaceutical and biomaterials technology. The reports w
| Author | : Vijay Kumar Thakur |
| Publisher | : Elsevier |
| Total Pages | : 596 |
| Release | : 2017-09-27 |
| Genre | : Technology & Engineering |
| ISBN | : 0128104619 |
Biopolymer Grafting: Synthesis and Properties presents the latest research and developments in fundamental of synthesis and properties of biopolymer-based graft copolymers. The book presents a broad overview of the biopolymer grafting process, along with trends in the field. It also introduces a range of grafting methods which lead to materials with enhanced properties for a range of practical applications, along with the positives and limitations of these techniques. The book bridges the knowledge gap between the scientific principles and industrial applications of polymer grafting. This book covers synthesis and characterization of graft-copolymers of plant polysaccharides, functional separation membranes from grafted biopolymers, and polysaccharides in alternative methods for insulin delivery. Recent trends and advances in this area are discussed, assisting materials scientists and researchers in mapping out the future of these new "green" materials through value addition to enhance their use. - Introduces polymer researchers to a promising, rapidly developing method for modifying naturally derived biopolymers - Provides a one-stop shop covering synthesis, properties, characterization and graft copolymerization of bio-based polymeric materials - Increases familiarity with a range of biopolymer grafting processes, enabling materials scientists and engineers to improve material properties and widen the range of potential biopolymer applications
