Pitfalls in Diagnostic Cytopathology With Key Differentiating Cytologic Features

Pitfalls in Diagnostic Cytopathology With Key Differentiating Cytologic Features
Author: Von G. Samedi
Publisher: Springer
Total Pages: 261
Release: 2016-09-22
Genre: Medical
ISBN: 3319398091

This book provides cytopathologists a succinct but comprehensive reference covering common diagnostic dilemmas caused by normal, iatrogenic, inflammatory and reactive/reparative changes in cytology samples. This book will provide immediate access to these confounders, clearly illustrating key features and detailing the pitfalls these cells engender in all cytologically accessible body sites. The text is organized in chapters corresponding to cytologically accessible body sites/organ systems. Each chapter’s discussions are further organized by general categories of confounders (i.e., normal contaminants, inflammatory, infectious and iatrogenic), with special attention to site specific confounders. Pitfalls in Diagnostic Cytopathology With Key Differentiating Cytologic Features will be of great value to practicing pathologists, pathology residents, cytopathology fellows, cytotechnology technologists and students.

Non-Neoplastic Cytology

Non-Neoplastic Cytology
Author: Syed M. Gilani
Publisher: Springer Nature
Total Pages: 359
Release: 2023-12-14
Genre: Medical
ISBN: 303144289X

Cytology evaluates cellular details, and in contrast, histology relates to tissue assessment with rather preserved architecture. During daily cytology practice, we frequently encounter certain situations which are often challenging such as differentiating normal cytology components or non-neoplastic lesions from a neoplastic process, abnormality versus artifact, contaminants from lesional sampling, immunostain expression in unexpected cells, identifying/or characterizing infectious microorganisms and use of special stains. In-depth knowledge about normal tissue cytology, the pattern of immunohistochemical expression in various organs, and recognizing diagnostic pitfalls would help to overcome diagnostically challenging situations. This book presents a detailed and state-of-the-art approach to non-neoplastic cytology. High-yield content, mostly used in daily practice, is in tabular format. The book provides detailed information about cytomorphologic features of infectious microorganisms and the use of special stains, the use of immunohistochemistry along with expression in normal cell types, artifacts/contaminants or incidental findings, and cytomorphologic features of non-tumor related lesions in an organ-based structure. There is a further elaboration of differential diagnosis and mimickers of cytologic material from normal parenchymal tissue, infectious/inflammatory conditions, and benign cystic lesions. The last chapter describes a quick overview of important reference material in tables, which is useful for daily anatomic pathology sign-out. Non-Neoplastic Cytology: A Comprehensive Guide provides practical information about non-neoplastic cytology in one concise format using tables and images. It aims to be a practical resource for cytotechnologists, pathologists, pathology residents, and fellows.

Normal Cytology

Normal Cytology
Author: Madelyn Lew
Publisher: Springer Nature
Total Pages: 174
Release: 2023-01-01
Genre: Medical
ISBN: 3031203364

In the practice of cytopathology, cytologists frequently encounter a spectrum of benign, normal cells in samples. In fact, these normal cells frequently comprise the greatest proportion of material present on a cytology slide. This is frequently the case in Pap smears of the uterine cervix , urine samples, and lung samples such as bronchial brushings. Normal cytology can often mimic pathology leading to misdiagnoses, especially in cases with reactive and metaplastic changes. Moreover, cytopathology findings of certain neoplasms can also mimic normal cytology. Today, cytology laboratories are no longer confined to dealing with just exfoliative specimens and superficial aspirations. With interventional radiology as well as endobronchial and endoscopic ultrasound-guided fine needle aspirations (FNA), we increasingly encounter visceral samples. Hence, cytologists are even likely to encounter normal elements from deep-seated organs. Sometimes, unexpected normal elements may be found within cytology specimens because a FNA procedure has contamination or inadvertently sampled a nearby organ or normal anatomical structure. A typical example is the finding of ganglion cells when a FNA is performed targeting a celiac node for cancer staging (Elgarby EA et al. Frequency and characterization of celiac ganglia diagnosed on fine-needle aspiration. Cytojournal. 2015; 12:4). Despite the importance of knowing the spectrum of normal cytology, there are limited reference materials available on this topic for cytologists. Most cytopathology texts deal with abnormal cytology. Often, the chapters in these books only devote a few sentences about normal cytology (euplasia). Our proposed book intends to fulfil this need. The book will contain a mixture of text and images (atlas). Important aspects related to cytology practice will be highlighted such as clinical relevance, differential diagnoses, mimics and pitfalls. The images will include a variety of cytology specimen preparations (e.g. direct smears, liquid based samples, touch preparations, cell blocks) and stains (e.g. Diff Quik/MGG, Papanicolaou, H&E). In selected cases, the expected immunoprofile of normal cells will be addressed. Each chapter will also include a modest list of helpful and contemporary references.

Diagnostic Cytopathology

Diagnostic Cytopathology
Author: Winifred Gray
Publisher: Elsevier Health Sciences
Total Pages: 947
Release: 2010-01-01
Genre: Medical
ISBN: 0702031542

The new edition of Diagnostic Cytopathology provides the practicing and trainee cytopathologist with a comprehensive guide to the diagnostic applications of exfoliative and aspiration cytology. The book covers normal and abnormal cytological findings encountered in all body sites where cytological applications are used. Appropriate histopathological, immunohistochemical and molecular correlations, together with a consideration of the possible differential diagnoses, accompany the cytological findings. The reader can see a full range of normal and abnormal findings with almost 2,000 full-colour images. The book is heavily referenced to ensure that it will serve as a practical resource for daily reference in the laboratory. A uniformity of basic chapter structure will help readers to quickly find the diagnostic answers they seek. This edition stresses not just the diagnostic cytological features of the various conditions encountered, but also the diagnostic pitfalls and the grey areas between so as to enable the reader to give more evidence-based reports. In recognition of their rapid expansion, there are new chapters on recent technological developments and on the cytodiagnosis of childhood tumours. A special section on the importance of multidisciplinary team meetings that include the cytopathologist as a core member of the team has also been included at the end of each chapter. As active members of this team, cytopathologists can define their role in the management pathway and thus bring the patient and the microscope together as never before. The full text can be accessed online and images downloaded via Expert Consult.

Orell, Orell and Sterrett's Fine Needle Aspiration Cytology E-Book

Orell, Orell and Sterrett's Fine Needle Aspiration Cytology E-Book
Author: Svante R Orell
Publisher: Elsevier Health Sciences
Total Pages: 495
Release: 2011-08-09
Genre: Medical
ISBN: 0702047554

Orell & Sterrett's Fine Needle Aspiration Cytology 5e provides you with a logical and systematic approach to the acquisition, interpretation and diagnosis of FNA biopsy samples. It is an ideal resource for all those requiring an authoritative and systematic review of the cytological findings in those malignant and benign lesions likely to be the target of FNA. The book is lavishly illustrated with high quality colour images that demonstrate the cytological features as well as their relevant immunohistochemical and molecular findings. Organized into anatomical regions, each chapter is consistently organized into two parts: the first deals with clinical and technical aspects followed by a systematic presentation of cytological findings. This is your perfect practical bench resource for daily reference in the laboratory. Provides practical tips and advice on how to avoid pitfalls and ensure accurate diagnoses. Over 1,200 colour illustrations capture each entity's cellular, morphological and immunohistochemical appearance. Chapters have been up-dated and revised and a brand new one on cytological findings in infectious diseases added. Both MGG and Pap smears illustrated in parallel as well as the corresponding histology to help provide side-by-side analysis. Access the full text online and download images via Expert Consult. Brand new chapter on cytological findings in infectious diseases. Inclusion of immuno-profiles and other relevant ancillary tests. New illustrations. New contributing authors. Available online via Expert Consult.

Diagnostic Cytopathology Board Review and Self-Assessment

Diagnostic Cytopathology Board Review and Self-Assessment
Author: Walid E. Khalbuss
Publisher: Springer
Total Pages: 762
Release: 2014-10-24
Genre: Medical
ISBN: 1493914774

Diagnostic Cytopathology Board Review and Self-Assessment provides a comprehensive systems-based review of non-gynecological cytology including cytomorphology, pitfalls and ancillary studies, presented in a high-yield format with board-type multiple choice questions and detailed answers. It provides an excellent review, resource and self-assessment for pathologists, cytopathologists and cytotechnologists, as well as trainees (pathology residents, cytopathology fellows and cytotechology students) who are preparing for board examinations or in-service examinations, in addition to those who are looking to fine-tune their cytology diagnostic skills. The volume is organized in a systems-based format including chapters covering lung, lymph nodes, pancreas, liver, gastrointestinal tract, thyroid, salivary gland, central nervous system, soft tissue and bone, kidney, adrenal, retroperitoneal and exfoliative cytology of urine, serous fluids and CSF. This book is enriched with the following features to maximize studying and review of cytopathology" HIGH YIELD REVIEW: Concise high-yield review with tables emphasizing key points, useful criteria and important concepts to maximize your score on board examinations and your diagnostic knowledge of exfoliative and aspiration cytopathology. BOARD EXAM-TYPE QUESTIONS: Over 800 board exam-type questions covering all areas of non-gynecological cytology with emphasis on cytomorphology, diagnostic pitfalls and ancillary studies, including detailed answers with in-depth discussions and key references from the literature and major cytopathology text books. HIGH QUALITY FULL-COLOR IMAGES: Over 600 high-quality full-color photomicrographs, including images of immunohistochemical stains and other ancillary studies performed.

Molecular Cytopathology

Molecular Cytopathology
Author: Bin Yang
Publisher: Springer
Total Pages: 297
Release: 2016-08-12
Genre: Medical
ISBN: 331930741X

This book reviews the current applications of molecular tools in cytopathology and provides a concise handbook for those who provide care in this era of personalized medicine. Specifically, the text provides a comprehensive and concise review of the emerging molecular tests available clinically in different subspecialities of diagnostic pathology. It reviews the current data of molecular testing already applied in cytopathology, discusses some of the biomarkers with potential utility in cytopathology in the near future and reviews the technical challenges in applying and validating molecular tools in liquid-based cytologic materials. Molecular Cytopathology will serve as a valuable resource for cytopathologists, cytotechnologists, pathology trainees, and clinicians with an interest in molecular applications in cytopathology.

Diagnostic Gynecologic and Obstetric Pathology E-Book

Diagnostic Gynecologic and Obstetric Pathology E-Book
Author: Christopher P. Crum
Publisher: Elsevier Health Sciences
Total Pages: 1217
Release: 2011-02-16
Genre: Medical
ISBN: 145570895X

Drs. Christopher P. Crum, Marisa R. Nucci, and Kenneth R. Lee help you diagnose neoplastic and non-neoplastic lesions of the female reproductive tract with their comprehensive update of Diagnostic Gynecologic and Obstetric Pathology. This 2nd Edition provides all of the latest guidance needed to accurately evaluate pathologic features and morphologic patterns. With 650+ new color images, an appendix with algorithms for the use of biomarkers, key points, diagnostic pearls, and more... this title is a must-have for today’s pathologist. Find distinct diagnostic/differential diagnostic criteria for any potential obstetric/gynecologic specimen encountered in practice. Integrate exfoliative cytology, immunohistochemistry, and molecular/genetic testing together with findings gleaned from the traditional open surgical biopsy. Examine the cytologic features of specimens taken from the uterine cervix and corpus, following the Bethesda classification of these lesions. View more than 2,250 full-color photographs and photomicrographs, ideal for side-by-side comparison to the specimens seen in the laboratory. Make better decisions regarding complex pregnancy situations with a new chapter devoted to the "Placental Correlates of Unanticipated Fetal Death." Experience easier reference with key points and diagnostic pearls at the end of each chapter, and a new appendix on algorithms for the use of biomarkers. Update your cancer assessment skills with the restructured section on pelvic epithelial malignancies, including a new chapter on "Assessing Pelvic Cancer Risk and Intercepting Early Malignancy." Gain the professional insights of new co-editor Dr. Marissa Nucci, an associate professor in pathology at the Harvard Medical School.

Cytopathology of the Head and Neck

Cytopathology of the Head and Neck
Author: Gabrijela Kocjan
Publisher: John Wiley & Sons
Total Pages: 215
Release: 2017-04-24
Genre: Medical
ISBN: 1118076028

Working practices for Head and Neck (HN) diagnostic and clinical teams have changed dramatically over the past 15 years with highlighted importance on specialist Multidisciplinary Teams (MDT) including radiologists and cytopathologists. To achieve high levels of diagnostic accuracy in this modern working environment, special training and commitment to cytopathology are required in addition to histopathology. Cytopathology of the Head and Neck: Ultrasound guided FNAC supports the learning of new skills expected of practicing pathologists by providing a comprehensive approach to cytopathology, including performing FNAC and on site interpretation. New to this edition is coverage of ultrasound (US) guidance the use of which has emerged as an essential adjunct to either Fine Needle Aspiration Cytology (FNAC) or needle core biopsy, and is expected to increase. US combined with US guided FNAC is now recommended as the investigation method of first choice for HN lesions for evaluating regional metastases in HN patients, for both those with and those without palpable lumps. This second edition also includes: Companion website containing ultrasound case histories which detail imaging findings, list differential diagnosis and suggest further investigations compiled by Dr Simon Morley Expanded coverage of clinical images of head and neck masses Clear presentation of FNAC diagnostic features with images Clinical management algorithms Examples of diagnostic of pitfalls and complications in FNAC This timely book fills the training gap required for pathologists and offers a team approach to head and neck lesions, with valuable input from radiologists, ENT (ear, nose, and throat) surgeons, oncologists, and medico-legal experts. This new edition reflects the emergent multidisciplinary approach to head and neck practice.