Pharmacological Treatment Of Chronic Stable Angina Pectoris
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Author | : Pablo Avanzas |
Publisher | : Springer |
Total Pages | : 290 |
Release | : 2015-06-02 |
Genre | : Medical |
ISBN | : 3319173324 |
This book is intended for general cardiologists and other physicians involved in the care of patients with chronic stable angina (CSA). The goal of this book is to update clinicians on recent data on the medical management of patients with CSA. Ischemic heart disease remains a major public health problem. Chronic stable angina is the initial manifestation of ischemic heart disease in approximately one half of patients. Stable coronary artery disease is generally characterized by episodes of reversible myocardial demand/supply mismatch, related to ischaemia or hypoxia, which are usually inducible by exercise, emotion or other stress and reproducible—but, which may also be occurring spontaneously. Such episodes of ischaemia/hypoxia are commonly associated with transient chest discomfort (angina pectoris). The aim of the management of CSA is to reduce symptoms and improve prognosis. The management of these patients encompasses lifestyle modification, control of coronary artery disease risk factors, evidence-based pharmacological therapy and patient education. All patients with stable angina should be offered optimal medical treatment, defined as one or two anti-anginal drugs as necessary, plus drugs for secondary prevention of cardiovascular disease. Regarding the role of revascularization, randomised trials provide compelling evidence that myocardial revascularisation by coronary artery bypass grafting or by percutaneous coronary intervention improves symptoms of angina relative to continued medical treatment.
Author | : Pablo Avanzas |
Publisher | : Springer |
Total Pages | : 0 |
Release | : 2015-06-12 |
Genre | : Medical |
ISBN | : 9783319173313 |
This book is intended for general cardiologists and other physicians involved in the care of patients with chronic stable angina (CSA). The goal of this book is to update clinicians on recent data on the medical management of patients with CSA. Ischemic heart disease remains a major public health problem. Chronic stable angina is the initial manifestation of ischemic heart disease in approximately one half of patients. Stable coronary artery disease is generally characterized by episodes of reversible myocardial demand/supply mismatch, related to ischaemia or hypoxia, which are usually inducible by exercise, emotion or other stress and reproducible—but, which may also be occurring spontaneously. Such episodes of ischaemia/hypoxia are commonly associated with transient chest discomfort (angina pectoris). The aim of the management of CSA is to reduce symptoms and improve prognosis. The management of these patients encompasses lifestyle modification, control of coronary artery disease risk factors, evidence-based pharmacological therapy and patient education. All patients with stable angina should be offered optimal medical treatment, defined as one or two anti-anginal drugs as necessary, plus drugs for secondary prevention of cardiovascular disease. Regarding the role of revascularization, randomised trials provide compelling evidence that myocardial revascularisation by coronary artery bypass grafting or by percutaneous coronary intervention improves symptoms of angina relative to continued medical treatment.
Author | : Filippo Crea |
Publisher | : Springer Science & Business Media |
Total Pages | : 263 |
Release | : 2013-08-15 |
Genre | : Medical |
ISBN | : 8847053676 |
In the past two decades a number of studies have shown that abnormalities in the function and structure of coronary microcirculation can be detected in several cardiovascular diseases. On the basis of the clinical setting in which it occurs, coronary microvascular dysfunction (CMD) can be classified into four types: CMD in the absence of any other cardiac disease; CMD in myocardial diseases; CMD in obstructive epicardial coronary artery disease; and iatrogenic CMD. In some instances CMD represents an epiphenomenon, whereas in others it represents an important marker of risk or may contribute to the pathogenesis of myocardial ischemia, thus becoming a possible therapeutic target. This book provides an update on coronary physiology and a systematic assessment of microvascular abnormalities in cardiovascular diseases, in the hope that it will assist clinicians in prevention, detection and management of CMD in their everyday activity.
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 304 |
Release | : 2010-12-04 |
Genre | : Medical |
ISBN | : 030915698X |
The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.
Author | : Juan Carlos Kaski |
Publisher | : Springer |
Total Pages | : 173 |
Release | : 2016-08-15 |
Genre | : Medical |
ISBN | : 3319411802 |
This title discusses the magnitude of the problem of angina pectoris. The author also goes on to describe the characteristics and clinical profile of patients with angina in a contemporary population. The different types and multiple mechanisms of angina pectoris are described, while the clinical presentation, typical and atypical features and complications (MI, HF) and clinical management and outcomes are evaluated. The author also evaluates the various antianginal therapies used in special populations: the elderly, post revascularised patients, patients with LVSD or HF, patients with CKD, patients with diabetes.
Author | : Paul A. Heidenreich |
Publisher | : Agency for Healthcare Research & Quality |
Total Pages | : 140 |
Release | : 1999 |
Genre | : Medical |
ISBN | : |
Author | : Dennis L. Kasper |
Publisher | : McGraw Hill Professional |
Total Pages | : 1248 |
Release | : 2019-10-22 |
Genre | : Medical |
ISBN | : 1260455351 |
Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. All the authority of the most trusted brand in medical content in a convenient, portable guide Derived from most clinically salient content featured in Harrison's Principles of Internal Medicine, 20th Edition, this full color, portable guide covers all diseases and conditions commonly seen in general medical practice. This edition has been updated to reflect the latest clinical developments in medicine. Designed for quick access and employing an effective blend of concise text, bulleted key points, decision trees, and summary tables, the Manual makes it easy to find what you need at the point of care. The easy-to-navigate chapters use a standard repeating template and cover: •Etiology and Epidemiology •Clinically Relevant Pathophysiology •Signs and Symptoms •Differential Diagnosis •Physical and Laboratory Findings •Therapeutics •Practice Guidelines, and more
Author | : Adam Schneeweiss |
Publisher | : Springer Science & Business Media |
Total Pages | : 80 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642746179 |
The· first meeting of the cardiovascular drug therapy forum took place on April 13-15, 1988 in Montreux, Switzerland. In this meeting, which was closed to the public, approximately 150 leading investigators in the field of cardiovascular drug therapy, both academics and from the pharmaceutical industry, discussed the state of the art and future trends of this rapidly expanding field. The discussions concentrated on four major topics: (1) ischemic heart disease; (2) heart failure; (3) hyper tension; (4) arrhythmias. These topics were discussed by four committees in parallel, and thereafter the main points were reviewed by the whole forum. This framework allowed both intensive and interdisciplinary discussions. This book, the first publication of selected topics from the meeting, focuses mainly on nitrate therapy in ischemic heart disease and heart failure. Adam Schneeweiss, MD Chairman v Contents Opening Remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Presentation of the Sir Thomas Lauder Brunton Award for Outstanding Nitrate Research . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Origins of Symptoms in Heart Failure - Relevance in Evaluation of New Drugs . . . . . . . . . . . . . . . . . . . . 5 Mononitrates in Congestive Heart Failure . . . . . . . . . . . . . . . . . 9 Are There Differences Between the Various Formulations of Nitrates in Heart Failure? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Long-Term Nitrate Therapy - A Decade of Changing Concepts . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Nitrate Therapy in Angina Pectoris . . . . . . . . . . . . . . . . . . . . . . . . 23 Mononitrates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 Transdermal Administration of Nitrates . . . . . . . . . . . . . . . . . . . 53 Nitrates in Angina Pectoris - Rationale of Use and Avoidance of Limitations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 Treatment of Congestive Heart Failure - Summary . . . . . . . .
Author | : Stephan Gielen |
Publisher | : European Society of Cardiology |
Total Pages | : 369 |
Release | : 2015 |
Genre | : Medical |
ISBN | : 0199656657 |
"EACPR, European Association for Cardiovascular Prevention and Rehabilitation -- European Society of Cardiology."
Author | : P. Needleman |
Publisher | : Springer Science & Business Media |
Total Pages | : 206 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 364266024X |
Nitroglycerin and other organic nitrates have been used for over a century in the treatment of angina pectoris. Millions of patients, throughout the world, have placed nitroglycerin tablets under the tongue and have experienced rapid and dramatic relief from the chest pain that frequently occurs as a manifestation of disease of the coronary arteries. The empirical observation of the safe use of nitrates for tile alleviation of the symptoms of angina have led to their widespread medical acceptance. The use of organic nitrates preceded any knowledge of their mechanism of action or their ultimate metabolic fate. Thus, more simply stated, although sub lingual nitrates helped the patients, little was known concerning what these drugs do to the body or what the body does to the drugs. A substantial number of investigators have focused on these questions especially during the last two decades. We now have considerably more insight into the pathways of degradation of organic nitrates and the relationship of the metabolic processes to the biological action of these agents. Similarly, considerable effort has been expended in understanding the mechanism of action of these agents directly on vascular smooth muscle and on cardiac work and performance. Finally, there is a more substantive understanding of the physiology of the coronary circulation as well as the" pathophysiologic manifestations of myocardial disease.