Pharmacological Approaches To The Treatment Of Brain And Spinal Cord Injury
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| Author | : Donald G. Stein |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 400 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1461309271 |
Although there are over 400,000 people each year in the United States alone who suffer from traumatic injury to the central nervous system (CNS), no phar macological treatment is currently available. Considering the enormity of the problem in terms of human tragedy as well as the economic burden to families and societies alike, it is surprising that so little effort is being made to develop treatments for these disorders. Although no one can become inured to the victims of brain or spinal cord injuries, one reason that insufficient time and effort have been devoted to research on recovery is that it is a generally held medical belief that nervous system injuries are simply not amenable to treatment. At best, current therapies are aimed at providing symptomatic relief or focus on re habilitative measures and the teaching of alternative behavioral strategies to help patients cope with their impairments, with only marginal results in many cases. Only within the last decade have neuroscientists begun to make serious inroads into understanding and examining the inherent "plasticity" found in the adult CNS. Ten years or so ago, very few researchers or clinicians would have thought that damaged central neurons could sprout new terminals or that intact nerve fibers in a damaged pathway could proliferate to replace inputs from neurons that died as a result of injury.
| Author | : Donald G Stein |
| Publisher | : |
| Total Pages | : 412 |
| Release | : 1988-05-01 |
| Genre | : |
| ISBN | : 9781461309284 |
| Author | : Robert Fitridge |
| Publisher | : University of Adelaide Press |
| Total Pages | : 589 |
| Release | : 2011 |
| Genre | : Medical |
| ISBN | : 1922064009 |
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 361 |
| Release | : 2005-08-27 |
| Genre | : Medical |
| ISBN | : 0309095859 |
An estimated 11,000 spinal cord injuries occur each year in the United States and more than 200,000 Americans suffer from maladies associated with spinal cord injury. This includes paralysis, bowel and bladder dysfunction, sexual dysfunction, respiratory impairment, temperature regulation problems, and chronic pain. During the last two decades, longstanding beliefs about the inability of the adult central nervous system to heal itself have been eroded by the flood of new information from research in the neurosciences and related fields. However, there are still no cures and the challenge of restoring function in the wake of spinal cord injuries remains extremely complex. Spinal Cord Injury examines the future directions for research with the goal to accelerate the development of cures for spinal cord injuries. While many of the recommendations are framed within the context of the specific needs articulated by the New York Spinal Cord Injury Research Board, the Institute of Medicine's panel of experts looked very broadly at research priorities relating to future directions for the field in general and make recommendations to strengthen and coordinate the existing infrastructure. Funders at federal and state agencies, academic organizations, pharmaceutical and device companies, and non-profit organizations will all find this book to be an essential resource as they examine their opportunities.
| Author | : Matilde Otero-Losada |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 350 |
| Release | : 2020-11-26 |
| Genre | : Medical |
| ISBN | : 1838804390 |
Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.
| Author | : Cristina Morganti-Kossmann |
| Publisher | : Cambridge University Press |
| Total Pages | : 361 |
| Release | : 2012-07-19 |
| Genre | : Medical |
| ISBN | : 1107007437 |
Presents the most up-to-date clinical and experimental research in neurotrauma in an illustrated, accessible, comprehensive volume.
| Author | : Michael Fehlings |
| Publisher | : Elsevier |
| Total Pages | : 644 |
| Release | : 2022-02-21 |
| Genre | : Medical |
| ISBN | : 0128198354 |
Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma provides readers with a comprehensive overview on the most up-to-date strategies to repair and regenerate the injured spinal cord following SCI and spine trauma. With contributions by international authors, chapters put regenerative approaches in context, allowing the reader to understand the challenges and future directions of regenerative therapies. Recent clinical trial advancements are thoroughly discussed, with the impact of trial findings addressed. Additionally, major ongoing clinical trials are included with thoughts from experts in the field. Recent clinical practice guidelines for the management of traumatic spinal cord injury are featured throughout. These guidelines are quickly being adopted as the standard of care worldwide, and the comprehensive information found within this book will place these recommendations in context with current knowledge surrounding spinal cord injury and spine trauma. Contains contributions by international authors Covers recent clinical trial advancements and findings and updates on ongoing trials Presents an overview of clinical practice guidelines for the management of traumatic spinal cord injury featured Provides the reader with insights regarding the translation of research from bench to bedside and the skills needed to understand the translational pathway using real-life examples
| Author | : William M. Reichert |
| Publisher | : CRC Press |
| Total Pages | : 300 |
| Release | : 2007-12-17 |
| Genre | : Medical |
| ISBN | : 1420009303 |
Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwel
| Author | : International Association for the Study of Pain. Research Symposium |
| Publisher | : Progress in Pain Research and |
| Total Pages | : 472 |
| Release | : 2002 |
| Genre | : Medical |
| ISBN | : |
| Author | : Firas H. Kobeissy |
| Publisher | : CRC Press |
| Total Pages | : 718 |
| Release | : 2015-02-25 |
| Genre | : Medical |
| ISBN | : 1466565993 |
With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
