Pharmaceutical Applications Of Atomic Spectroscopy
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| Author | : Tim Shelbourn |
| Publisher | : Wiley |
| Total Pages | : 448 |
| Release | : 2020-06-30 |
| Genre | : Science |
| ISBN | : 9780470627778 |
This book emphasizes practical applications of modern atomicspectroscopic techniques across the entire pharmaceutical valuechain, including inductively coupled plasma (ICP) optical emissionspectroscopy, ICP mass spectrometry, atomic absorption, and laserinduced breakdown spectroscopy. This includes both samplepreparation and analysis of marketed API and excipients andanalytical support of delivery device and container systemdevelopment as well as process synthesis chemistry. Uniquepharmaceutical applications of hyphenated techniques such aHPLC-ICP-MS and laser ablation ICP-MS will also beincluded. Method validation and regulatory compliance strategies foratomic spectroscopy assays per regional, international andharmonized compendia are also addressed
| Author | : Muhammad Sajid Hamid Akash |
| Publisher | : Springer Nature |
| Total Pages | : 235 |
| Release | : 2019-12-17 |
| Genre | : Medical |
| ISBN | : 9811515476 |
Recent advances in the pharmaceutical sciences and biotechnology have facilitated the production, design, formulation and use of various types of pharmaceuticals and biopharmaceuticals. This book provides detailed information on the background, basic principles, and components of techniques used for the analysis of pharmaceuticals and biopharmaceuticals. Focusing on those analytical techniques that are most frequently used for pharmaceuticals, it classifies them into three major sections and 19 chapters, each of which discusses a respective technique in detail. Chiefly intended for graduate students in the pharmaceutical sciences, the book will familiarize them with the components, working principles and practical applications of these indispensable analytical techniques.
| Author | : Bernhard Welz |
| Publisher | : John Wiley & Sons |
| Total Pages | : 965 |
| Release | : 2008-11-21 |
| Genre | : Science |
| ISBN | : 3527611681 |
The thoroughly revised new edition of this best-seller, presents the wide use of AAS in numerous fields of application. The comparison between the different AAS techniques enables the reader to find the best solution for his analytical problem. Authors Bernhard Welz and Michael Sperling have succeeded in finding a balance between theoretical fundamentals and practical applications. The new chapter 'physical fundamentals' describes the basic principles of AAS. The development of AAS is now described in a separate chapter. Further new chapters are devoted to the latest developments in the field of flow injection and the use of computers for laboratory automation. Methodological progress e. g. speciation analysis is also covered in this new edition. The index and the extensive bibliography make this book a unique source of information. It will prove useful not only for analytical chemists, out also spectroscopists in industry, institutes, and universities. Atomic Absorption Spectrometry will also be invaluable for clinics and research institutes in the fields of biochemistry, medicine, food technology, geology, metallurgy, petrochemistry, and mineralogy.
| Author | : Gary D. Christian |
| Publisher | : |
| Total Pages | : 520 |
| Release | : 1979 |
| Genre | : Science |
| ISBN | : |
| Author | : Sunil Jawla |
| Publisher | : LAP Lambert Academic Publishing |
| Total Pages | : 80 |
| Release | : 2013 |
| Genre | : |
| ISBN | : 9783659409059 |
Naproxen and ibuprofen (aryl propionic acid derivatives) both are classified as non-steroidal anti-inflammatory agents. Except HPLC, no sensitive methods were reported for both the drugs. HPLC methods suffer from two drawbacks- first; requirement of costly chemicals and second; more time consuming. Because atomic absorption spectroscopy (AAS) methods are simple, sensitive, rapid, reproducible and uses low cost chemicals. The objective of present research work was to develop highly sensitive and economical analytical methods for the quantitative estimation of naproxen and ibuprofen in pharmaceutical formulations by AAS. The methods were based on the reaction of naproxen and ibuprofen with copper and cobalt chloride to form coloured metal complexes. These complexes were extracted with organic solvents and digested with acids. Naproxen and ibuprofen were indirectly estimated by AAS via the determination of the copper and cobalt content in the formed complexes. The proposed methods may be used for routine analysis of pharmaceutical formulations containing aryl propionic acid derivatives and similar pharmaceutical drugs by the analytical chemist.
| Author | : Robert Thomas |
| Publisher | : CRC Press |
| Total Pages | : 474 |
| Release | : 2018-01-29 |
| Genre | : Medical |
| ISBN | : 1351984403 |
Recent regulations on heavy metal testing have required the pharmaceutical industry to monitor a suite of elemental impurities in pharmaceutical raw materials, drug products and dietary supplements. These new directives s are described in the new United States Pharmacopeia (USP) Chapters , , and , together with Q3D, Step 4 guidelines for elemental impurities, drafted by the ICH (International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use), a consortium of global pharmaceutical associations, including the European Pharmacopeia (Ph.Eur.), the Japanese Pharmacopeia (JP) and the USP. This book provides a complete guide to the analytical methodology, instrumental techniques and sample preparation procedures used for measuring elemental impurities in pharmaceutical and nutraceutical materials. It offers readers the tools to better understand plasma spectrochemistry to optimize detection capability for the full suite of elemental PDE (Permitted Daily Exposure) levels in the various drug delivery categories. Other relevant information covered in the book includes: The complete guide to measuring elemental impurities in pharmaceutical and nutraceutical materials. Covers heavy metals testing in the pharmaceutical industry from an historical perspective. Gives an overview of current USP Chapters and and ICH Q3D Step 4 Guidelines. Explains the purpose of validation protocols used in Chapter , including how J-values are calculated Describes fundamental principles and practical capabilities of ICP-MS and ICP-OES. Offers guidelines about the optimum strategy for risk assessment Provides tips on how best to prepare and present your data for regulatory inspection. An indispensable resource, the fundamental principles and practical benefits of ICP-OES and ICP-MS are covered in a reader-friendly format that a novice, who is carrying out elemental impurities testing in the pharmaceutical and nutraceutical communities, will find easy to understand.
| Author | : Sune Svanberg |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 418 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 3642973981 |
A wide-ranging review of modern techniques in atomic and molecular spectroscopy. A brief description of atomic and molecular structure is followed by the relevant energy structure expressions. A discussion of radiative properties and the origin of spectra leads into coverage of X-ray and photoelectron spectroscopy, optical spectroscopy, and radiofrequency and microwave techniques. The treatment of laser spectroscopy investigates various tunable sources and a wide range of techniques characterized by high sensitivity and high resolution. Throughout this book, the relation between fundamental and applied aspects is shown, in particular by descriptions of applications to chemical analysis, photochemistry, surface characterisation, environmental and medical diagnostics, remote sensing and astrophysics.
| Author | : Rita Kakkar |
| Publisher | : Cambridge University Press |
| Total Pages | : 440 |
| Release | : 2015-05-14 |
| Genre | : Science |
| ISBN | : 1316395391 |
Spectroscopy is the study of electromagnetic radiation and its interaction with solid, liquid, gas and plasma. It is one of the widely used analytical techniques to study the structure of atoms and molecules. The technique is also employed to obtain information about atoms and molecules as a result of their distinctive spectra. The fast-spreading field of spectroscopic applications has made a noteworthy influence on many disciplines, including energy research, chemical processing, environmental protection and medicine. This book aims to introduce students to the topic of spectroscopy. The author has avoided the mathematical aspects of the subject as far as possible; they appear in the text only when inevitable. Including topics such as time-dependent perturbation theory, laser action and applications of Group Theory in interpretation of spectra, the book offers a detailed coverage of the basic concepts and applications of spectroscopy.
| Author | : Lena Ohannesian |
| Publisher | : CRC Press |
| Total Pages | : 605 |
| Release | : 2001-11-09 |
| Genre | : Medical |
| ISBN | : 0824741943 |
Exploring the analysis of pharmaceuticals, including polymorphic forms, this book discusses regulatory requirements in pharmaceutical product development and pharmaceutical testing. It covers methods of drug separation and procedures such as capillary electrophoresis for chromatographic separation of molecules. Additional topics include drug formulation analysis using vibrational and magnetic resonance spectroscopy and identification of drug metabolites and decomposition products using such techniques as mass spectrometry. The book provides more than 300 tables, equations, drawings, and photographs, and convenient, easy-to-use indices, facilitating quick access to each topic.
| Author | : Robert Thomas |
| Publisher | : CRC Press |
| Total Pages | : 457 |
| Release | : 2018-01-29 |
| Genre | : Medical |
| ISBN | : 135198439X |
Recent regulations on heavy metal testing have required the pharmaceutical industry to monitor a suite of elemental impurities in pharmaceutical raw materials, drug products and dietary supplements. These new directives s are described in the new United States Pharmacopeia (USP) Chapters , , and , together with Q3D, Step 4 guidelines for elemental impurities, drafted by the ICH (International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use), a consortium of global pharmaceutical associations, including the European Pharmacopeia (Ph.Eur.), the Japanese Pharmacopeia (JP) and the USP. This book provides a complete guide to the analytical methodology, instrumental techniques and sample preparation procedures used for measuring elemental impurities in pharmaceutical and nutraceutical materials. It offers readers the tools to better understand plasma spectrochemistry to optimize detection capability for the full suite of elemental PDE (Permitted Daily Exposure) levels in the various drug delivery categories. Other relevant information covered in the book includes: The complete guide to measuring elemental impurities in pharmaceutical and nutraceutical materials. Covers heavy metals testing in the pharmaceutical industry from an historical perspective. Gives an overview of current USP Chapters and and ICH Q3D Step 4 Guidelines. Explains the purpose of validation protocols used in Chapter , including how J-values are calculated Describes fundamental principles and practical capabilities of ICP-MS and ICP-OES. Offers guidelines about the optimum strategy for risk assessment Provides tips on how best to prepare and present your data for regulatory inspection. An indispensable resource, the fundamental principles and practical benefits of ICP-OES and ICP-MS are covered in a reader-friendly format that a novice, who is carrying out elemental impurities testing in the pharmaceutical and nutraceutical communities, will find easy to understand.
