We are delighted to present the Proceedings of the 4th International Conference on Innovation in Education, Science and Culture (ICIESC) that organized by Research and Community Service Centre of Universitas Negeri Medan (LPPM UNIMED). Proceedings of the 4th ICIESC contains several papers that have presented at the seminar with theme Education and Science in time of uncertainty: Recovering for the Future. This conference was held on 11 October 2022 virtually and become a routine agenda annually. The 4th ICIESC was realized this year with various presenters, lecturers, researchers and students from universities both in and out of Indonesia. The 4th International Conference on Innovation in Education, Science and Culture (ICIESC) 2022 shows up as a Mathematics and Natural Science, Material Science, Physics Education, Biology Education, Chemistry Education, Vocational Education, Applied Sciences-Computers, Multimedia Technology, Applied Mathematics, E-learning system, Applied Sciences-Information Technology, Applied Sciences-Engineering, Social Science and Humanities, Management Innovation and Heritage Culture research platform to gather presentations and discussions of recent achievements by leading researchers in academic research. With the number participants 260 participants, who came from the various national and international universities member, research institute, and academician. There are 181 papers passed through rigorous reviews process and accepted by the committee. All of papers reflect the conference scopes and become the latest trend. It has been our privilege to convene this conference. Our sincere thanks, to the conference organizing committee; to the Program Chairs for their wise advice and brilliant suggestion on organizing the technical program and to the Program Committee for their through and timely reviewing of the papers. Recognition should go to the Local Organizing Committee members who have all worked extremely hard for the details of important aspects of the conference programs and social activities. We welcome you to read this proceeding and hope the reader can find according to your interests and scientific field.