Decades before the Salem Witch trials, 11 people were hanged as witches in the Connecticut River Valley. The advent of witch hunting in New England was directly influenced by the English Civil War and the witch trials in England led by Matthew Hopkins, who pioneered "techniques" for examining witches. This history examines the outbreak of witch hysteria in the Valley, focusing on accusations of demonic possession, apotropaic magic and the role of the clergy. Although the hysteria was eventually quelled by a progressive magistrate unwilling to try witches, accounts of the trials later influenced contemporary writers during the Salem witch hunts. The source of the document "Grounds for Examination of a Witch" is identified.