Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 455 Performance Based Test Guideline For Stably Transfected Transactivation In Vitro Assays To Detect Estrogen Receptor Agonists And Antagonists
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Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 74 |
Release | : 2021-06-17 |
Genre | : |
ISBN | : 9264265295 |
This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays).
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 53 |
Release | : 2015-07-28 |
Genre | : |
ISBN | : 9264243046 |
This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays).
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 39 |
Release | : 2012-10-02 |
Genre | : |
ISBN | : 9264185380 |
This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provides the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists (ER TAs). It comprises mechanistically and functionally similar test ...
Author | : Organisation de coopération et de développement économiques |
Publisher | : |
Total Pages | : 54 |
Release | : 2015 |
Genre | : |
ISBN | : |
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 26 |
Release | : 2012-10-02 |
Genre | : |
ISBN | : 9264185399 |
This Test Guideline describes an in vitro assay, which provides concentration-response data for substances with in vitro ER agonist and antagonist activity. The test system utilises the BG1Luc4E2 cell line derived from a human ovarian adenocarcinoma ...
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 84 |
Release | : 2023-07-04 |
Genre | : |
ISBN | : 9264264361 |
This Test Guideline describes in vitro assays, which use Androgen Receptor TransActivation (ARTA) to detect Androgen Receptor Agonists and Antagonists. The ARTA assay methods are mechanistically and functionally similar test methods that provide information on the transcription and translation of a reporter gene following the binding of a chemical to the androgen receptor and subsequent transactivation.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 60 |
Release | : 2024-06-25 |
Genre | : |
ISBN | : 9264242627 |
This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology for human recombinant in vitro assays to detect substances with estrogen receptor binding affinity (hrER binding assays).
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 45 |
Release | : 2021-06-17 |
Genre | : |
ISBN | : 9264886109 |
The EASZY assay is a mechanism-based in vivo screening assay designed to detect endocrine active chemicals acting as agonist through estrogen receptors (ERs), by inducing the expression of the green fluorescent protein (GFP) driven by the cyp19a1b promoter. The EASZY assay allows for the detection of estrogenic activity of chemicals on transgenic tg(cyp19a1b:GFP) Zebrafish embryos exposed for 96 hours during the embryonic stages of development.
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 206 |
Release | : 2018-12-10 |
Genre | : |
ISBN | : 9264304797 |
In the past several decades, there has been a substantial increase in the availability of in vitro test methods for evaluating chemical safety in an international regulatory context. To foster confidence in in vitro alternatives to animal testing, the test methods and conditions under which ...
Author | : Ramesh C Gupta |
Publisher | : Academic Press |
Total Pages | : 1558 |
Release | : 2022-02-11 |
Genre | : Medical |
ISBN | : 0323915604 |
Reproductive and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource, providing the latest literature on this complex subject by focusing on three core components - parent, placenta and fetus - and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, and metals, among others. In addition, it is the only resource to include reproductive and developmental toxicity in domestic animals, fish and wildlife With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages. Completely revised and updated to include the most recent developments in the field, this book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists and teratologists from academia, industry and regulatory agencies. Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis Includes new chapters on developments in systems toxicology and predictive modeling of male developmental toxicity, adverse outcome pathways in reproductive and developmental toxicology, ovarian and endometrial toxicity, developmental neurotoxicity of air pollution, and more