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| Author | : Rudolf J. Schweyen |
| Publisher | : Walter de Gruyter GmbH & Co KG |
| Total Pages | : 676 |
| Release | : 2019-11-18 |
| Genre | : Science |
| ISBN | : 3111646831 |
Papers presented at the Schliersee Meeting on Nucleo-mitochondrial Interactions, held July 19-23, 1983.
| Author | : Keshav Singh |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 294 |
| Release | : 2009-04-05 |
| Genre | : Medical |
| ISBN | : 0387848355 |
Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.
| Author | : James A. Dykens |
| Publisher | : John Wiley & Sons |
| Total Pages | : 648 |
| Release | : 2008-09-11 |
| Genre | : Science |
| ISBN | : 0470372524 |
This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences.
| Author | : Geoffrey E. Hill |
| Publisher | : |
| Total Pages | : 315 |
| Release | : 2019 |
| Genre | : Science |
| ISBN | : 0198818254 |
This novel text provides a concise synthesis of how the interactions between mitochondrial and nuclear genes have played a major role in shaping the ecology and evolution of eukaryotes. The foundation for this new focus on mitonuclear interactions originated from research in biochemistry and cell biology laboratories, although the broader ecological and evolutionary implications have yet to be fully explored. The imperative for mitonuclear coadaptation is proposed to be a major selective force in the evolution of sexual reproduction and two mating types in eukaryotes, in the formation of species, in the evolution of ornaments and sexual selection, in the process of adaptation, and in the evolution of senescence. The book highlights the importance of mitonuclear coadaptation to the evolution of complex life and champions mitonuclear ecology as an important subdiscipline in ecology and evolution.
| Author | : Immo E. Scheffler |
| Publisher | : John Wiley & Sons |
| Total Pages | : 377 |
| Release | : 2011-09-20 |
| Genre | : Science |
| ISBN | : 1118209850 |
"This volume inspires. It certainly will be much appreciated by cell biologists all over the world." Quarterly Review of Biology, March 2009 This book is the eagerly awaited second edition of the best-selling Mitochondria, a book widely acknowledged as the first modern, truly comprehensive authored work on the important, scientifically fundamental topic of the cellular organelles known as mitochondria. This new edition brings readers completely up to date on the many significant findings that have occurred in the eight years since the book was first published. As in that seminal first edition, the second edition tackles the biochemistry, genetics, and pathology of mitochondria in different organisms. The new edition provides thorough updates of all literature concerning this vital organelle, its functions, ongoing research surrounding it, and its importance vis-à-vis a broad range of issues in cellular and molecular biology. The book includes detailed descriptions of current and developing technologies around mitochondrial research and discovery, and highlights subjects that are growing, such as the use of proteomics. This book is an invaluable resource for all geneticists, biologists, and educators in life sciences. It is also of interest for advanced students in genetics and molecular biology.
| Author | : Jan A.M. Smeitink |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 216 |
| Release | : 2007-03-06 |
| Genre | : Medical |
| ISBN | : 0387269924 |
Mitochondrial diseases are often hard to diagnose. From the time they were first researched without animal models, patients of mitochondrial diseases were of equal interest to both clinical and basic scientists. With the new research done, this book includes updates on the normal structure, function, and molecular biology of the mitochondrial respiratory chain, information on traditional diagnostical methodologies, and an overview of the diagnostic promise of new technologies. The hypermetabolism of Luft disease, although only seen twice, is also studied. There are critical reviews of symptoms and signs associated with syndromes, as well as updates on the genetic defects of either the mitochondrial or the nuclear genome responsible for many disorders.
| Author | : P. Christen |
| Publisher | : Springer |
| Total Pages | : 175 |
| Release | : 2013-12-21 |
| Genre | : Science |
| ISBN | : 364275189X |
EJB Reviews 1989 offer the collection of all reviews published in the European Journal of Biochemistry in one handy volume. This series of review articles by leading scientists covers emerging and rapidly growing fields of research in fundamental as well as in applied areas of biochemistry, such as medicine, biotechnology, agriculture and nutrition. Novel methodological and technological approaches which stimulate biochemical research are also included. All authors review their field in a very critical, selective, evaluative manner, with emphasis on interdisciplinary aspects wherever possible.
| Author | : J.W. Bennett |
| Publisher | : Elsevier |
| Total Pages | : 579 |
| Release | : 2012-12-02 |
| Genre | : Nature |
| ISBN | : 0323145418 |
Gene Manipulations in Fungi combines a review of classical fungal genetics, contemporary research, and responsible speculation about the future. This book focuses on yeasts and molds; because yeast is the primary model system for eukaryotes and that there is an elegant research on molds. The applications of fungi, including their economic importance, are addressed. The book emphasizes the need for improved transformation systems, appropriate vectors, and broadly applicable selectable markers in this field of interest. This book will help stimulate the development of innovative approaches in this subject matter.
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 331 |
| Release | : 2003-08-28 |
| Genre | : Science |
| ISBN | : 0080527450 |
The purpose of this volume is to highlight wide-ranging applications of genomics in the area of applied mycology and biotechnology.The volume covers: a brief overview on fungal genomics; meiotic recombination in fungi; molecular genetics of circadian rhythms; genome sequencing; transposable elements; mitochondrial genomes; ribosome biogenesis; pathogenicity genes; genetic improvement of yeasts; microarrays: techniques and applications; fungal germplasm and data bases. Although it is difficult to develop a comprehensive volume on fungal genomics because of the range and complexity of the emerging knowledge, an attempt has been made to bring together pertinent information that will serve the needs of the reader, provide a quick reference to material that might otherwise be difficult to locate, and furnish a starting point for further study.
