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| Author | : Holger Barth |
| Publisher | : MDPI |
| Total Pages | : 125 |
| Release | : 2018-07-09 |
| Genre | : Science |
| ISBN | : 3038424307 |
This book is a printed edition of the Special Issue "Novel Pharmacological Inhibitors for Bacterial Protein Toxins" that was published in Toxins
| Author | : Joseph E. Alouf |
| Publisher | : Elsevier |
| Total Pages | : 1072 |
| Release | : 2005-12-20 |
| Genre | : Science |
| ISBN | : 0080456987 |
This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. - Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France - 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology - Includes the major toxins of both basic and clinical interest are described in depth - Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology - Evolutionary and functional aspects of bacterial toxins evaluated and summarized - Toxin applications in cell biology presented - Therapy (cancer therapy, dystonias) discussed - Vaccines (native and genetically engineered vaccines) featured - Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.
| Author | : K. Aktories |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 713 |
| Release | : 2013-03-14 |
| Genre | : Medical |
| ISBN | : 3662059711 |
In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.
| Author | : Roger Finch |
| Publisher | : OUP Oxford |
| Total Pages | : 409 |
| Release | : 2012-01-05 |
| Genre | : Medical |
| ISBN | : 0191628654 |
Antimicrobial agents are essential for the treatment of life-threatening infections and for managing the burden of minor infections in the community. In addition, they play a key role in organ and bone marrow transplantation, cancer chemotherapy, artificial joint and heart valve surgery. Unlike other classes of medicines, they are vulnerable to resistance from mutations in target microorganisms, and their adverse effects may extend to other patients (increased risk of cross-infection). As a consequence, there is a constant requirement for new agents, as well as practices that ensure the continued effective prescribing of licensed agents. Public awareness and concerns about drug resistant organisms has led to widespread publicity and political action in the UK, Europe and worldwide. The control of drug resistance and the implementation of good prescribing practice are now legal requirements in the UK as a result of the UK Health Act (2008). These fundamental changes underscore the need for a thorough understanding of the advantages and risks associated with specific antibiotic choices. This sixth edition of Antimicrobial Chemotherapy continues to be a valuable resource for undergraduates and graduates requiring a thorough grounding in the scientific basis and clinical application of these drugs. This new edition is updated to include the most recently licensed agents, notably in the treatment of viral infections including HIV/AIDS, and contains new guidance on prescribing practice and infection control practices that limit the development and spread of resistant organisms.
| Author | : Andrei I. Ivanov |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 407 |
| Release | : 2008 |
| Genre | : Medical |
| ISBN | : 1588298655 |
In this book, skilled experts provide the most up-to-date, step-by-step laboratory protocols for examining molecular machinery and biological functions of exocytosis and endocytosis in vitro and in vivo. The book is insightful to both newcomers and seasoned professionals. It offers a unique and highly practical guide to versatile laboratory tools developed to study various aspects of intracellular vesicle trafficking in simple model systems and living organisms.
| Author | : P. Gopalakrishnakone |
| Publisher | : Springer |
| Total Pages | : 502 |
| Release | : 2018-03-14 |
| Genre | : Medical |
| ISBN | : 9789400764484 |
In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.
| Author | : W. Scott Champney |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 274 |
| Release | : 2008-01-15 |
| Genre | : Medical |
| ISBN | : 1588299155 |
This book examines specific techniques which can be used to explore new drug targets and the effectiveness of new antibiotics. By testing new antimicrobial agents and modified existing drugs, the most vulnerable cell processes, such as cell wall and membrane synthesis, DNA replication, RNA transcription and protein synthesis, can be better exploited. This in-depth volume, however, delves even deeper by identifying additional novel cellular targets for these new therapies. The book will provide laboratory investigators with the vital tools they need to test the antimicrobial potential of products and to curb the rise of so many infectious diseases.
| Author | : Jacqueline Burchum |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 1456 |
| Release | : 2018-03-27 |
| Genre | : Medical |
| ISBN | : 0323550061 |
With a clear explanation of drug prototypes and how they work, Lehne's Pharmacology for Nursing Care, 10th Edition gives you the background you need to understand drugs currently on the market, and those not yet released. This perennial favorite of students and teachers simplifies complex concepts while distinguishing need-to-know content from the material that’s merely nice to know. The 10th edition includes updated drug content to reflect the very latest FDA approvals, withdrawals, and therapeutic uses, as well as corresponding updated nursing content. It also includes an updated prototype drugs section, summarizing their major uses, and an updated table detailing care throughout the lifespan of the patient. Additionally, each chapter ends with a nursing implications summary to help you fully understand the material and apply it to clinical nursing practice. Prototype Drugs features serve as a quick-reference learning aid so you can apply your understanding to related drugs currently on the market as well as drugs that will be released in the future. UNIQUE! Engaging writing style with clear explanations makes difficult pharmacology concepts easy to grasp and even enjoyable to learn. Nursing implications of drug therapy are integrated throughout the text to reinforce the integral relationship between drug therapy and nursing care. UPDATED Special Interest Topic boxes focus on currently trending issues in pharmacology, eliminating out-of-date content. Large print highlights essential, need-to-know information, and small print indicates nice-to-know information. QSEN focus includes Patient-Centered Care Across the Life Span features highlighting safe and appropriate patient care during different phases of life. Safety Alert features emphasize the QSEN competency relating to patient safety. Student-friendly features make learning easier with concise drug summary tables, chapter outlines, key points, and a visual guide to the prototype drugs in each class. Concise drug summary tables present detailed information for individual drugs, including drug class, generic and trade names, dosages, routes, and indications. Selected Canadian drug names are indicated with a maple-leaf icon throughout the text. Separate Bioterrorism chapter discusses the clinical manifestations and treatment of biological weapon attacks. NEW! Thoroughly updated drug content reflects the very latest FDA drug approvals, withdrawals, and therapeutic uses, as well as corresponding updated nursing content NEW! Additional images included to accompany difficult concepts. NEW! Inclusion of more student practice questions provide additional help for learning the material.
| Author | : Lynn Wecker |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 798 |
| Release | : 2024-02-02 |
| Genre | : Medical |
| ISBN | : 0323846742 |
Brody's Human Pharmacology is a well-established and much-loved textbook that guides students of medicine, pharmacology and other health professions through pharmacology from both basic and clinical perspectives. What can be a very difficult and complex topic is divided into easily digestible chapters, each of which is clearly structured from a therapeutic overview to mechanisms of action, relationships to clinical responses, pharmacokinetics, pharmacovigilance, new developments, and clinical relevance for all health professionals. - Contains all the essential aspects of pharmacology – suitable for exam preparation - Full color illustrations explain important processes and color-coded boxes enhance understanding - Therapeutic overviews, clinical problems and trade names – everything you need to know - Self-assessment questions and further reading to reinforce learning - Current developments for each class of drugs and how information relates to students in the healthcare professions bring learning to life - Updated content throughout - Pharmacodynamics chapter revised to include discussions of positive and negative allosteric modulators, as well as biased agonism - Pharmacogenetics chapter considers genetic variations and their relationship to drug responses - Section on cancer drugs revised to reflect major advances - New chapter on immunological and cell-based therapies
| Author | : I DR. KANNAN |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 355 |
| Release | : 2023-07-03 |
| Genre | : Medical |
| ISBN | : 8131257851 |
This book primarily fulfils the content needs of Applied Microbiology and Infection Control Practices for Third Semester of B.Sc. Nursing students. Further, the book contains contents that help the nurses in profession to hone their microbiology knowledge used in their day-to-day practice. It contains all the updated vital aspects of infection control practices and the details of various infections suggested by WHO. The book provides the nursing interventions in the various areas of applied microbiology that will help them to sharpen their nursing skills. • All microbiology information needed for the undergraduate nursing students put in a systematic manner. • Concepts explained in lucid language for easy understanding by nursing students. • Content presented as bulleted lists for quick grasp of the subject matter. • Appropriate WHO guidelines and latest recommendations of infection control practices included. • Multicolour photographs, illustrations are used to explain complex microbiology concepts. • Content is completely based on the revised INC Syllabus with focus on Applied Microbiology • The content has been divided into two sections. Part A covers Applied Microbiology and Part B covers Infection Control & Safety • New! Content related to Infection Control and Safety has been added as a separate section. • New! Role of Infection Control Nurse in prevention of Healthcare-associated Infections (HAIs) has been added. • New! 7 new chapters have been added to this edition namely: ? Clinical Specimen Collection Techniques ? Healthcare-associated Infections (HAIs) ? Isolation Precautions and Other Infection Control Practices (Infection control practices including hand hygiene) ? Patient Safety Indicators ? International Patient Safety Goals (IPSG) ? Clinical Safety Protocol ? Hospital Employee Safety Indicators (HESI)
