The Endothelium

The Endothelium
Author: Michel Félétou
Publisher: Morgan & Claypool Publishers
Total Pages: 309
Release: 2011
Genre: Science
ISBN: 1615041230

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References

Anesthesia E-Book

Anesthesia E-Book
Author: Ronald D. Miller
Publisher: Elsevier Health Sciences
Total Pages: 3220
Release: 2009-06-24
Genre: Medical
ISBN: 1437720617

From fundamental principles to advanced subspecialty procedures, Miller’s Anesthesia covers the full scope of contemporary anesthesia practice. It is the go-to reference for masterful guidance on the technical, scientific, and clinical challenges you face. Now new chapters, new authors, meticulous updates, an increased international presence, and a new full-color design ensure that the 7th edition continues the tradition of excellence that you depend on. Covers the full scope of contemporary anesthesia practice. Offers step-by-step instructions for patient management and an in-depth analysis of ancillary responsibilities and problems. Incorporates ‘Key Points’ boxes in every chapter that highlight important concepts. Extends the breadth of international coverage with contributions from prominent anesthesiologists from all over the world, including China, India, and Sweden. Features 30 new authors and 13 new chapters such as Sleep, Memory and Consciousness; Perioperative Cognitive Dysfunction; Ultrasound Guidance for Regional Anesthesia; Anesthesia for Correction of Cardiac Arrhythmias; Anesthesia for Bariatric Surgery; Prehospital Emergency and Trauma Care; Critical Care Protocols; Neurocritical Care; and Renal Replacement Therapy. Dedicates an entire section to pediatric anesthesia, to help you address the unique needs of pediatric patients. Presents a new full-color design -- complete with more than 1,500 full-color illustrations -- for enhanced visual guidance.

Index Medicus

Index Medicus
Author:
Publisher:
Total Pages: 2160
Release: 2004
Genre: Medicine
ISBN:

Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

cGMP: Generators, Effectors and Therapeutic Implications

cGMP: Generators, Effectors and Therapeutic Implications
Author: Harald H. H. W. Schmidt
Publisher: Springer Science & Business Media
Total Pages: 581
Release: 2008-12-17
Genre: Science
ISBN: 3540689648

After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.