Neutron Scattering In Biology
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| Author | : Jörg Fitter |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 571 |
| Release | : 2006-05-01 |
| Genre | : Science |
| ISBN | : 3540291113 |
The advent of new neutron facilities and the improvement of existing sources and instruments world wide supply the biological community with many new opportunities in the areas of structural biology and biological physics. The present volume offers a clear description of the various neutron-scattering techniques currently being used to answer biologically relevant questions. Their utility is illustrated through examples by some of the leading researchers in the field of neutron scattering. This volume will be a reference for researchers and a step-by-step guide for young scientists entering the field and the advanced graduate student.
| Author | : Philip C H Mitchell |
| Publisher | : World Scientific |
| Total Pages | : 670 |
| Release | : 2005-06-15 |
| Genre | : Science |
| ISBN | : 9814482005 |
Inelastic neutron scattering (INS) is a spectroscopic technique in which neutrons are used to probe the dynamics of atoms and molecules in solids and liquids. This book is the first, since the late 1960s, to cover the principles and applications of INS as a vibrational-spectroscopic technique. It provides a hands-on account of the use of INS, concentrating on how neutron vibrational spectroscopy can be employed to obtain chemical information on a range of materials that are of interest to chemists, biologists, materials scientists, surface scientists and catalyst researchers. This is an accessible and comprehensive single-volume primary text and reference source.
| Author | : L.A. Feigin |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 339 |
| Release | : 2013-11-11 |
| Genre | : Science |
| ISBN | : 1475766246 |
Small-angle scattering of X rays and neutrons is a widely used diffraction method for studying the structure of matter. This method of elastic scattering is used in various branches of science and technology, includ ing condensed matter physics, molecular biology and biophysics, polymer science, and metallurgy. Many small-angle scattering studies are of value for pure science and practical applications. It is well known that the most general and informative method for investigating the spatial structure of matter is based on wave-diffraction phenomena. In diffraction experiments a primary beam of radiation influences a studied object, and the scattering pattern is analyzed. In principle, this analysis allows one to obtain information on the structure of a substance with a spatial resolution determined by the wavelength of the radiation. Diffraction methods are used for studying matter on all scales, from elementary particles to macro-objects. The use of X rays, neutrons, and electron beams, with wavelengths of about 1 A, permits the study of the condensed state of matter, solids and liquids, down to atomic resolution. Determination of the atomic structure of crystals, i.e., the arrangement of atoms in a unit cell, is an important example of this line of investigation.
| Author | : Barnali Chaudhuri |
| Publisher | : Springer |
| Total Pages | : 269 |
| Release | : 2017-12-07 |
| Genre | : Science |
| ISBN | : 981106038X |
This book provides a clear, comprehensible and up-to-date description of how Small Angle Scattering (SAS) can help structural biology researchers. SAS is an efficient technique that offers structural information on how biological macromolecules behave in solution. SAS provides distinct and complementary data for integrative structural biology approaches in combination with other widely used probes, such as X-ray crystallography, Nuclear magnetic resonance, Mass spectrometry and Cryo-electron Microscopy. The development of brilliant synchrotron small-angle X-ray scattering (SAXS) beam lines has increased the number of researchers interested in solution scattering. SAS is especially useful for studying conformational changes in proteins, highly flexible proteins, and intrinsically disordered proteins. Small-angle neutron scattering (SANS) with neutron contrast variation is ideally suited for studying multi-component assemblies as well as membrane proteins that are stabilized in surfactant micelles or vesicles. SAS is also used for studying dynamic processes of protein fibrillation in amyloid diseases, and pharmaceutical drug delivery. The combination with size-exclusion chromatography further increases the range of SAS applications. The book is written by leading experts in solution SAS methodologies. The principles and theoretical background of various SAS techniques are included, along with practical aspects that range from sample preparation to data presentation for publication. Topics covered include techniques for improving data quality and analysis, as well as different scientific applications of SAS. With abundant illustrations and practical tips, we hope the clear explanations of the principles and the reviews on the latest progresses will serve as a guide through all aspects of biological solution SAS. The scope of this book is particularly relevant for structural biology researchers who are new to SAS. Advanced users of the technique will find it helpful for exploring the diversity of solution SAS methods and applications. Chapter 3 of this book is available open access under a CC BY 4.0 license at link.springer.com.
| Author | : Jean-Paul Renaud |
| Publisher | : John Wiley & Sons |
| Total Pages | : 1437 |
| Release | : 2020-01-09 |
| Genre | : Medical |
| ISBN | : 1118900502 |
With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins
| Author | : VICTORIA GARCIA SAKAI |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 455 |
| Release | : 2011-12-19 |
| Genre | : Technology & Engineering |
| ISBN | : 1461407265 |
Dynamics of Soft Matter: Neutron Applications provides an overview of neutron scattering techniques that measure temporal and spatial correlations simultaneously, at the microscopic and/or mesoscopic scale. These techniques offer answers to new questions arising at the interface of physics, chemistry, and biology. Knowledge of the dynamics at these levels is crucial to understanding the soft matter field, which includes colloids, polymers, membranes, biological macromolecules, foams, emulsions towards biological & biomimetic systems, and phenomena involving wetting, friction, adhesion, or microfluidics. Emphasizing the complementarities of scattering techniques with other spectroscopic ones, this volume also highlights the potential gain in combining techniques such as rheology, NMR, light scattering, dielectric spectroscopy, as well as synchrotron radiation experiments. Key areas covered include polymer science, biological materials, complex fluids and surface science.
| Author | : |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 512 |
| Release | : 2020-07-09 |
| Genre | : |
| ISBN | : 0198862318 |
Neutron scattering is arguably the most powerful technique available for looking inside materials and seeing what the atoms are doing. This textbook provides a comprehensive and up-to-date account of the many different ways neutrons are being used to investigate the behaviour of atoms and molecules in bulk matter. It is written in a pedagogical style, and includes many examples and exercises. Every year, thousands of experiments are performed at neutron scattering facilities around the world, exploring phenomena in physics, chemistry, materials science, as well as in interdisciplinary areas such as biology, materials engineering, and cultural heritage. This book fulfils a need for a modern and pedagogical treatment of the principles behind the various different neutron techniques, in order to provide scientists with the essential formal tools to design their experiments and interpret the results. The book will be of particular interest to researchers using neutrons to study the atomic-scale structure and dynamics in crystalline solids, simple liquids and molecular fluids by diffraction techniques, including small-angle scattering and reflectometry, and by spectroscopic methods, ranging from conventional techniques for inelastic and quasielastic scattering to neutron spin-echo and Compton scattering. A comprehensive treatment of magnetic neutron scattering is given, including the many and diverse applications of polarized neutrons.
| Author | : Barbara J Gabrys |
| Publisher | : CRC Press |
| Total Pages | : 378 |
| Release | : 2000-12-21 |
| Genre | : Science |
| ISBN | : 9789056993009 |
Neutrons, which are a penetrating yet non destructive probe, are ideally suited to studying the structure, organisation and motion of molecules responsible for the physical properties of materials under a variety of conditions. Applications are in fields as diverse as colloid and polymer science, earth sciences, pharmaceutics, biology and engineering. This book will be of interest to both present and potential future users of neutron sources working in these areas, as both a useful reference and a comprehensive overview.
| Author | : Sow-Hsin Chen |
| Publisher | : |
| Total Pages | : 434 |
| Release | : 1974 |
| Genre | : Science |
| ISBN | : |
Spectroscopy in Biology and Chemistry discusses the use of thermal neutron diffraction and inelastic scattering, and the related techniques of x-ray diffraction, Raman and Rayleigh scattering, in investigating biological macromolecules and chemical systems. The book describes neutron, x-ray and laser spectroscopy; quasielastic scattering in neutron and laser spectroscopy; and interatomic forces, molecular structure and molecular vibrations. The text also discusses the x-ray crystallography of biological molecules; neutron diffraction studies of hydrogen bonding in organic and biochemical syste ...
| Author | : Redouane Borsali |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 1490 |
| Release | : 2008-07-28 |
| Genre | : Science |
| ISBN | : 140204464X |
This 2-volume set includes extensive discussions of scattering techniques (light, neutron and X-ray) and related fluctuation and grating techniques that are at the forefront of this field. Most of the scattering techniques are Fourier space techniques. Recent advances have seen the development of powerful direct imaging methods such as atomic force microscopy and scanning probe microscopy. In addition, techniques that can be used to manipulate soft matter on the nanometer scale are also in rapid development. These include the scanning probe microscopy technique mentioned above as well as optical and magnetic tweezers.
