Neuropeptide Analogs Conjugates And Fragments
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| Author | : P. Michael Conn |
| Publisher | : Academic Press |
| Total Pages | : 415 |
| Release | : 2013-10-22 |
| Genre | : Science |
| ISBN | : 1483217531 |
Methods in Neurosciences, Volume 13: Neuropeptide Analogs, Conjugates, and Fragments covers the synthesis and characterization of peptide analogs, conjugates, and fragments, their use as ligands for receptors, and their role in the development and use of antisera. The book discusses techniques such as novel synthetic approaches; biotinylation; purification and characterization; radioligand techniques and assay development; use of agonists and antagonists; distinguishing receptor subtypes; conjugation to carrier proteins; antiidiotypic antibody development; and radiolabeling. Neuroscientists, biochemists, neurochemists, and pharmacologists will find the book useful.
| Author | : P. Michael Conn |
| Publisher | : Academic Press |
| Total Pages | : 497 |
| Release | : 2013-10-22 |
| Genre | : Science |
| ISBN | : 148326937X |
Methods in Neurosciences, Volume 14: Paradigms for the Study of Behavior is a collection of articles that describes the methods for measuring a wide range of behavior. This volume covers the means for measuring different behaviors, such as reproductive, maternal, sexual, aggression, social interactions, feeding behavior, memory analysis, and classical conditioning. The opening papers outline the proper conditions and practical considerations in which the researcher can study the sexual and reproductive behavior of animals in the laboratory. Another paper describes how to assess aggressiveness in rodents including ethical issues involved in such study. The book then discusses the effects of intracerebral administration of neuropeptides in rats using surgical and stereotaxic methods. Another paper presents the measurement of behavioral thermoregulatory reflexes to show acuity of temperature sensation and thermoregulatory control. This volume also discusses the measurement of song-learning behavior in birds through ""sensorimotor,"" ""action-based,"" and ""sensory"" methods of learning. This book will be helpful for students, scientists, technicians, and laboratory workers whose work involves experiments that need to be accurately measured.
| Author | : Patrick C. Roche |
| Publisher | : Elsevier |
| Total Pages | : 429 |
| Release | : 1996-03-27 |
| Genre | : Science |
| ISBN | : 0080532276 |
| Author | : E. Ronald de Kloet |
| Publisher | : Academic Press |
| Total Pages | : 573 |
| Release | : 2013-10-22 |
| Genre | : Science |
| ISBN | : 1483288366 |
Steroid hormones are unique compounds in that they are active at the interface of peripheral endocrine events and neural mechanisms. Thus their effects present an important peripheral signaling system to alter brain function. This volume presents state-of-the-art and classical techniques for the study of steroid hormones and their receptors and their effects and actions. - Comprehensive protocols included for the study of Steroid kinetics and metabolism - Steroid receptors - Molecular and cellular effects of steroids - Steroid effects on integrated systems
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 375 |
| Release | : 1996-09-18 |
| Genre | : Science |
| ISBN | : 0080536379 |
Although the function of nitric oxide in a regulatory capacity in the central and peripheral nervous system is widely recognized, the full scope of its actions and its interrelationships with other classes of regulatory molecules is just beginning to be comprehended. This volume contains a number of sophisticated and advanced methods essential for exploring the activity of nitric oxide in the brain. It will be a valuable tool for the established investigator and for those just entering the field. - Comprehensive protocols included for detection of NO and related compounds by chemical, immunohistochemical, and in situ hybridization techniques - Newly developed methods for the purification of neuronal and endothelial NO synthase, production of monoclonal antibodies to NO synthase, molecular cloning and expression of NO synthesis, and control of NO synthase gene expression - Assessment of NO-mediated functions in neurons, central nervous system, cerebral circulation, synaptic transmission, and vascular tone - Calcium imaging by confocal microscopy, evaluation of the effect of NO on iron metabolism, and detection of heme oxygenase-1 and -2 message level and distribution
| Author | : Paul A. Hargrave |
| Publisher | : Academic Press |
| Total Pages | : 425 |
| Release | : 2013-10-22 |
| Genre | : Science |
| ISBN | : 148321754X |
Photoreceptor Cells, Volume 15 covers the advances in the study of photoreceptor cells. The book discusses biochemical, cell and structural biological, and molecular biological techniques needed for the study of photoreceptor cells. The text also describes the methods for observing the structure of photoreceptor cells and for studying their metabolism. The procedures for photoreceptor cell isolation are also considered. The book further tackles the preparation of proteins involved in rod cell metabolism, with particular emphasis on proteins of the visual transduction cascade. The text also encompasses the application of molecular biological techniques for the examination of molecular components of the visual system and their structure, distribution, and function. Neuroscientists, ophthalmologists, biochemists, and people involved in the study of photoreceptor cells will find the book invaluable.
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 537 |
| Release | : 1995-03-22 |
| Genre | : Science |
| ISBN | : 0080536441 |
The volumes in this series include contemporary techniques significant to a particular branch of neuroscience. They are an invaluable aid to the student as well as the experienced researcher not only in developing protocols in neuroscience but in disciplines where research is becoming closely related to neuroscience. Each volume of Methods in Neurosciences contains an index, and each chapter includes references. Dr. Conn became Editor-in-Chief of the series beginning with Volume 15, so each subsequent volume could be guest-edited by an expert in that specific field. This further strengthens the depth of coverage in Methods in Neurosciences for students and researchers alike. - Cloning - Expression systems - Signal transduction - Structure-function techniques - Antireceptor antibodies - Regulation - 3-D receptor modeling and computational probing
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 355 |
| Release | : 1996-05-23 |
| Genre | : Medical |
| ISBN | : 0080536484 |
This volume includes paradigms, model systems, and techniques for the study of dysfunctions in the nervous system. The advantages and disadvantages of the approaches presented are critically discussed. - Neural injury - Developmental cell death - Disease processes and aging
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 475 |
| Release | : 1995-04-13 |
| Genre | : Science |
| ISBN | : 008053645X |
The volumes in this series include contemporary techniques significant to a particular branch of neuroscience. They are an invaluable aid to the student as well as the experienced researcher not only in developing protocols in neuroscience but in disciplines where research is becoming closely related to neuroscience. Each volume of Methods in Neurosciences contains an index, and each chapter includes references. Dr. Conn became Editor-in-Chief of the series beginning with Volume 15, so each subsequent volume could be guest-edited by an expert in that specific field. This further strengthens the depth of coverage in Methods in Neurosciences for students and researchers alike. - Direct application of PCR to fresh or frozen clinical specimens (e.g., blood and solid tissue) - Complete retrieval of novel expressed genes by PCR without screening a library - Quantitation by PCR - Mutagenesis by PCR - PCR in AIDS research - Simple and effective protocols for PCR on archival specimens
| Author | : P. Michael Conn |
| Publisher | : Academic Press |
| Total Pages | : 457 |
| Release | : 2013-10-22 |
| Genre | : Science |
| ISBN | : 1483259706 |
Methods in Neurosciences, Volume 11: Receptors: Model Systems and Specific Receptors is a compilation of papers that describes techniques and information that are important to the neurosciences. This volume discusses preferred receptor techniques, molecular techniques, and methods to determine receptor subclasses and localization in the ligand design. The first paper discusses the steroid receptor found in the central nervous system for steroid hormones that affects strongly the structure and function of both developed and immature nervous systems. Another paper describes how a glycoprotein of 79.5 kDa (transferrin) carries iron in the blood stream for delivery to different tissues, after the transferrin has bound with a specific receptor on the surface of the cell. This book also explains the binding sites of pituitary adenylate cyclase-activating polypeptide in the human brain, while one paper analyzes the neurotensin receptors during the primary culture of neurons. This volume then also analyzes the structure and function of the fast nerve growth factor receptor, particularly how a signal on the outside of a cell is transmitted to the cell's interior. This collection is helpful for microbiologists, cellular researchers, students, and professors in the discipline of neurosciences.
