Natural History Studies
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Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 335 |
Release | : 2010-06-25 |
Genre | : Medical |
ISBN | : 0309157277 |
Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 442 |
Release | : 2011-04-03 |
Genre | : Medical |
ISBN | : 0309158060 |
Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.
Author | : Agency for Healthcare Research and Quality/AHRQ |
Publisher | : Government Printing Office |
Total Pages | : 385 |
Release | : 2014-04-01 |
Genre | : Medical |
ISBN | : 1587634333 |
This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews.
Author | : Raymond A. Huml |
Publisher | : Springer Nature |
Total Pages | : 418 |
Release | : 2021-11-08 |
Genre | : Medical |
ISBN | : 3030786056 |
This book provides a broad overview of rare disease drug development. It offers unique insights from various perspectives, including third-party capital providers, caregivers, patient advocacy groups, drug development professionals, marketing and commercial experts, and patients. A unique reference, the book begins with narratives on the many challenges faced by rare disease patient and their caregivers. Subsequent chapters underscore the critical, multidimensional role of patient advocacy groups and the novel approaches to related clinical trials, investment decisions, and the optimization of rare disease registries. The book addresses various rare disease drug development processes by disciplines such as oncology, hematology, pediatrics, and gene therapy. Chapters then address the operational aspects of drug development, including approval processes, development accelerations, and market access strategies. The book concludes with reflections on the authors' case for real-world data and evidence generation in orphan medicinal drug development. Rare Disease Drug Development is an expertly written text optimized for biopharmaceutical R&D experts, commercial experts, third-party capital providers, patient advocacy groups, patients, and caregivers.
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 120 |
Release | : 2002-06-14 |
Genre | : Medical |
ISBN | : 0309182905 |
In a workshop organized by the Clinical Research roundtable, representatives from purchaser organizations (employers), payer organizations (health plans and insurance companies), and other stakeholder organizations (voluntary health associations, clinical researchers, research organizations, and the technology community) came together to explore: What do purchasers and payers need from the Clinical Research Enterprise? How have current efforts in clinical research met their needs? What are purchasers, payers, and other stakeholders willing to contribute to the enterprise? This book documents these discussions and summarizes what employers and insurers need from and are willing to contribute to clinical research from both a business and a national health care perspective.
Author | : Eric Dorfman |
Publisher | : Routledge |
Total Pages | : 381 |
Release | : 2017-10-12 |
Genre | : Social Science |
ISBN | : 1315531879 |
Natural history museums are changing, both because of their own internal development and in response to changes in context. Historically, the aim of collecting from nature was to develop encyclopedic assemblages to satisfy human curiosity and build a basis for taxonomic information. Today, with global biodiversity in rapid decline, there are new reasons to build and maintain collections, while audiences are more diverse, numerous, and technically savvy. Institutions must learn to embrace new technology while retaining the authenticity of their stories and the value placed on their objects. The Future of Natural History Museums begins to develop a cohesive discourse that balances the disparate issues that our institutions will face over the next decades. It disassembles the topic into various key elements and, through commentary and synthesis, explores a cohesive picture of the trajectory of the natural history museum sector. This book contributes to the study of collections, teaching and learning, ethics, and running non-profit businesses and will be of interest to museum and heritage professionals and academics and senior students in Biological Sciences and Museum Studies.
Author | : Alan C. L. Yu |
Publisher | : Oxford University Press, USA |
Total Pages | : 278 |
Release | : 2007-07-05 |
Genre | : Language Arts & Disciplines |
ISBN | : 0199279381 |
The first cross-linguistic study of infixation explores its prosodic, phonological, and morphological characteristics, considers its diverse functions, and formulates a general theory to explain the rules and constraints by which it is governed. It examines 154 infixation patterns from over a hundred languages, compares their formal properties and explores their diachronic origins. The book will interest phonologists, morphologists, typologists, and historical linguists of all theoretical persuasions.
Author | : William W. Fitzhugh |
Publisher | : University of Washington Press |
Total Pages | : 424 |
Release | : 1999 |
Genre | : History |
ISBN | : |
"Some 55 scholars, mostly Japanese but with a considerable number from the US and Europe, write about the ethnicity, theories of origin, history, economies, art, religious beliefs, mythology, and other aspects of the culture of the Ainu, the indigenous people of Japan, now principally found in Hokkaido and smaller far northern islands. Hundreds of photographs and paintings, mostly in excellent quality color, show a wide variety of Ainu people, as well as clothing, jewelry, and various artifacts."--"Choice". "The most in-depth treatise available on Ainu prehistory, material culture, and ethnohistory." - "Library Journal".--Amazon.com (2001 ed, book description).
Author | : Kathryn Olivarius |
Publisher | : Harvard University Press |
Total Pages | : 353 |
Release | : 2022-04-19 |
Genre | : HISTORY |
ISBN | : 0674241053 |
Introduction: A rising necropolis -- Patriotic fever -- Danse macabre -- Immunocapital -- Public health, private acclimation -- Denial, delusion, and disunion -- Incumbent arrogance -- Epilogue: Fever and folly.
Author | : Jared Diamond |
Publisher | : Harvard University Press |
Total Pages | : 290 |
Release | : 2012-10-01 |
Genre | : History |
ISBN | : 0674076729 |
Some central questions in the natural and social sciences can't be answered by controlled laboratory experiments, often considered to be the hallmark of the scientific method. This impossibility holds for any science concerned with the past. In addition, many manipulative experiments, while possible, would be considered immoral or illegal. One has to devise other methods of observing, describing, and explaining the world. In the historical disciplines, a fruitful approach has been to use natural experiments or the comparative method. This book consists of eight comparative studies drawn from history, archeology, economics, economic history, geography, and political science. The studies cover a spectrum of approaches, ranging from a non-quantitative narrative style in the early chapters to quantitative statistical analyses in the later chapters. The studies range from a simple two-way comparison of Haiti and the Dominican Republic, which share the island of Hispaniola, to comparisons of 81 Pacific islands and 233 areas of India. The societies discussed are contemporary ones, literate societies of recent centuries, and non-literate past societies. Geographically, they include the United States, Mexico, Brazil, western Europe, tropical Africa, India, Siberia, Australia, New Zealand, and other Pacific islands. In an Afterword, the editors discuss how to cope with methodological problems common to these and other natural experiments of history.